Zobrazeno 1 - 10 of 11 pro vyhledávání: '"Lavanya M Iyer"'
1
Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control
Autor: Laura C Zelarayan, Ali El-Armouche, Lavanya M Iyer, Anke Renger, Wolfram-Hubertus Zimmermann, Andreas Jungmann, Claudia Noack, Matthias Dewenter, Franziska S Rathjens, Karl Toischer, Larissa Fabritz, Fahima Syeda, Maria-Patapia Zafeiriou, Alica Blenkle, Oliver J. Müller
Publikováno v: Cardiovascular Research
Aims Arrhythmias and sudden cardiac death (SCD) occur commonly in patients with heart failure. We found T-box 5 (TBX5) dysregulated in ventricular myocardium from heart failure patients and thus we hypothesized that TBX5 reduction contributes to arrh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23405a5a5638ee33855c8e919f42015c
http://europepmc.org/articles/PMC8262635
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2
Dysferlin links excitation–contraction coupling to structure and maintenance of the cardiac transverse–axial tubule system
Autor: Lavanya M Iyer, Lars Klinge, Julia Hofhuis, Sven Thoms, Viacheslav O. Nikolaev, Funsho E Fakuade, Lars S. Maier, Karl Toischer, Cristina E. Molina, Laura C Zelarayan, Kristina Bersch, Stefan Wagner, Niels Voigt, Katrin Streckfuss-Bömeke
Publikováno v: EP Europace. 22:1119-1131
Aims The multi-C2 domain protein dysferlin localizes to the T-Tubule system of skeletal and heart muscles. In skeletal muscle, dysferlin is known to play a role in membrane repair and in T-tubule biogenesis and maintenance. Dysferlin deficiency manif
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79acc1778e385ee9e5cdbebbc3abc70e
https://doi.org/10.1093/europace/euaa093
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3
CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart
Autor: Wei Tan, Laura C Zelarayan, Claudia Noack, Rhonda Bassel-Duby, Shirin Doroudgar, Julia Groß, Nicole Herzog, Wolfram H. Zimmermann, Ning Liu, Orr Shomroni, John R. McAnally, Kelli J. Carroll, Eric Schoger, Gabriela Salinas, Lavanya M Iyer
Publikováno v: Circulation Research. 126:6-24
Rationale: Genome editing by CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 is evolving rapidly. Recently, second-generation CRISPR/Cas9 activation systems based on nuclease inactive dead (d)Cas9 fused to transcriptional tran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f2527f1eff6e4f539df68b29e51144
https://doi.org/10.1161/circresaha.118.314522
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4
Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium
Autor: Stefan Luther, Florian Spreckelsen, Florian Rehfeldt, Lavanya M Iyer, Laura C Zelarayan, Ulrich Parlitz, Wolfram-Hubertus Zimmermann, Susanne F. Schlick, Malte Tiburcy, Tim Meyer
Publikováno v: Progress in Biophysics and Molecular Biology. 144:51-60
Cardiomyocyte and stroma cell cross-talk is essential for the formation of collagen-based engineered heart muscle, including engineered human myocardium (EHM). Fibroblasts are a main component of the myocardial stroma. We hypothesize that fibroblasts
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8f0607068c56eb8507eab92394e525
https://doi.org/10.1016/j.pbiomolbio.2018.11.011
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5
Abstract 498: Krueppel-like Factor 15 Modulation: A Crispr-based Re-establishment of Homeostatic Transcription in Diseased Mouse and Human Cardiomyocytes
Autor: Orr Shomroni, Cheila Rocha, Gabriela Salinas, Laura C Zelarayan, Mareike Jassyk, Eric Schoger, Lavanya M Iyer, Claudia Noack
Publikováno v: Circulation Research. 127
An altered transcriptomic profile of cardiomyocytes is a hallmark of cardiac remodelling and heart failure. Re-activation of gene programs necessary for myocardial homeostasis and inhibition of deleterious signalling pathways, such as Wnt/beta-cateni
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39d1a72bdf4956af07779de733ad9277
https://doi.org/10.1161/res.127.suppl_1.498
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6
Abstract 377: KLF15-TCF7L2-dependent Cardiac Transcriptional Reprogramming Induces Cardiomyocyte and Vascular Cell Remodeling in the Mammalian Heart
Autor: Laura C Zelarayan, Eva Wagner, Wolfram-Hubertus Zimmermann, Enno Klussmann, Norman Y. Liaw, Lavanya M Iyer, Claudia Noack, Kerstin Zuehlke, Eric Schoger
Publikováno v: Circulation Research. 125
Integrative biochemical and omic-based approaches have refined our understanding of how cells integrate the Wnt signal at the chromatin level to yield specific cellular responses. However, this aspect remains unexplored in the heart. Since Wnt/β-cat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::79265410c0da0dce2aa3e4c0330e7941
https://doi.org/10.1161/res.125.suppl_1.377
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7
Abstract 372: CRISPR-based Gene Activation for Transcriptional Reprograming of Mammalian Cardiomyocytes
Autor: John McAnally, Lavanya M Iyer, Eric Schoger, Rhonda Bassel-Duby, Wei Tan, Laura C Zelarayan, Kelli J. Carroll, Claudia Noack, Wolfram H. Zimmermann, Norman Y. Liaw
Publikováno v: Circulation Research. 125
Cardiac remodelling is accompanied by silencing of genes necessary for cardiac homeostasis including Krüppel-like factor 15 ( Klf15 ), an anti-hypertrophic factor. Due to a lack of tools for gene activation, we aim to adapt a CRISPR-based approach f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9d8f54e9e7d33385a8d7daf33e9c7a44
https://doi.org/10.1161/res.125.suppl_1.372
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