SIRT3 Is a Critical Regulator of Mitochondrial Function of Fibroblasts in Pulmonary Hypertension.

Autor: Min Li, Plecitá-Hlavatá, Lydie, Dobrinskikh, Evgenia, McKeon, B. Alexandre, Gandjeva, Aneta, Riddle, Suzette, Laux, Aya, Prasad, Ram Raj, Kumar, Sushil, Tuder, Rubin M., Hui Zhang, Cheng-Jun Hu, Stenmark, Kurt R.

Publikováno v: American Journal of Respiratory Cell & Molecular Biology; Nov2023, Vol. 69 Issue 5, p570-583, 32p

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Suppression of HIF2 signalling attenuates the initiation of hypoxia-induced pulmonary hypertension.

Autor: Hu CJ; Dept of Craniofacial Biology, School of Dental Medicine, University of Colorado, Aurora, CO, USA.; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA.; These authors share first authorship.; These authors are joint corresponding authors., Poth JM; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA.; Dept of Anesthesiology and Intensive Care Medicine, University Medical Center, Rheinische Friedrich Wilhelms University of Bonn, Bonn, Germany.; These authors share first authorship., Zhang H; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Flockton A; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Laux A; Dept of Craniofacial Biology, School of Dental Medicine, University of Colorado, Aurora, CO, USA., Kumar S; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., McKeon B; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Mouradian G; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Li M; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Riddle S; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Pugliese SC; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Brown RD; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Wallace EM; Peloton Therapeutics Inc., Dallas, TX, USA., Graham BB; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Frid MG; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA., Stenmark KR; Cardiovascular Pulmonary Research Laboratories, Division of Pulmonary Sciences and Critical Care Medicine, Division of Pediatrics-Critical Care, Depts of Medicine and Pediatrics, University of Colorado, Aurora, CO, USA kurt.stenmark@ucdenver.edu.; These authors are joint corresponding authors.

Publikováno v: The European respiratory journal [Eur Respir J] 2019 Dec 12; Vol. 54 (6). Date of Electronic Publication: 2019 Dec 12 (Print Publication: 2019).