Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β.

Autor: De Groof, Timo W.M., Lauwers, Yoline, De Pauw, Tessa, Saxena, Mohit, Vincke, Cécile, Van Craenenbroeck, Jolien, Chapon, Catherine, Le Grand, Roger, Raes, Geert, Naninck, Thibaut, Van Ginderachter, Jo A., Devoogdt, Nick

Publikováno v: European Journal of Nuclear Medicine & Molecular Imaging; Dec2024, Vol. 52 Issue 1, p193-207, 15p

Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer.

Autor: Lauwers Y; Molecular Imaging and Therapy Research Group, Vrije Universiteit Brussel, Brussels 1090, Belgium., De Groof TWM; Molecular Imaging and Therapy Research Group, Vrije Universiteit Brussel, Brussels 1090, Belgium., Vincke C; Laboratory of Myeloid Cell Immunology, Vlaams Instituut voor Biotechnologie Center for Inflammation Research, Brussels 1050, Belgium.; Laboratory of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels 1050, Belgium., Van Craenenbroeck J; Laboratory of Myeloid Cell Immunology, Vlaams Instituut voor Biotechnologie Center for Inflammation Research, Brussels 1050, Belgium.; Laboratory of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels 1050, Belgium., Jumapili NA; Laboratory of Myeloid Cell Immunology, Vlaams Instituut voor Biotechnologie Center for Inflammation Research, Brussels 1050, Belgium.; Laboratory of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels 1050, Belgium., Barthelmess RM; Laboratory of Myeloid Cell Immunology, Vlaams Instituut voor Biotechnologie Center for Inflammation Research, Brussels 1050, Belgium.; Laboratory of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels 1050, Belgium., Courtoy G; Department of Pathology, Universitair Ziekenhuis Brussel, Brussels B-1090, Belgium.; Laboratory of Experimental Pathology, Supporting Clinical Sciences, Vrije Universiteit Brussel, Brussels B-1090, Belgium., Waelput W; Department of Pathology, Universitair Ziekenhuis Brussel, Brussels B-1090, Belgium.; Laboratory of Experimental Pathology, Supporting Clinical Sciences, Vrije Universiteit Brussel, Brussels B-1090, Belgium., De Pauw T; Molecular Imaging and Therapy Research Group, Vrije Universiteit Brussel, Brussels 1090, Belgium., Raes G; Laboratory of Myeloid Cell Immunology, Vlaams Instituut voor Biotechnologie Center for Inflammation Research, Brussels 1050, Belgium.; Laboratory of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels 1050, Belgium., Devoogdt N; Molecular Imaging and Therapy Research Group, Vrije Universiteit Brussel, Brussels 1090, Belgium., Van Ginderachter JA; Laboratory of Myeloid Cell Immunology, Vlaams Instituut voor Biotechnologie Center for Inflammation Research, Brussels 1050, Belgium.; Laboratory of Cellular and Molecular Immunology, Brussels Center for Immunology, Vrije Universiteit Brussel, Brussels 1050, Belgium.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Dec 24; Vol. 121 (52), pp. e2409668121. Date of Electronic Publication: 2024 Dec 18.