Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Laurynas Mockeliūnas"'
Autor:
Caryn M. Upton, Rob C. van Wijk, Laurynas Mockeliunas, Ulrika S.H. Simonsson, Kirsten McHarry, Gerben van den Hoogen, Chantal Muller, Arne von Delft, Helene-Mari van der Westhuizen, Reinout van Crevel, Gerhard Walzl, Pedro M. Baptista, Jonathan Peter, Andreas H. Diacon
Publikováno v:
EClinicalMedicine, Vol 48, Iss , Pp 101414- (2022)
Summary: Background: BCG vaccination prevents severe childhood tuberculosis (TB) and was introduced in South Africa in the 1950s. It is hypothesised that BCG trains the innate immune system by inducing epigenetic and functional reprogramming, thus pr
Externí odkaz:
https://doaj.org/article/bee787c1ea524116a9c3153c9ea56b8a
Autor:
Laurynas Mockeliunas, Lina Keutzer, Marieke G. G. Sturkenboom, Mathieu S. Bolhuis, Lotte M. G. Hulskotte, Onno W. Akkerman, Ulrika S. H. Simonsson
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 753 (2022)
Linezolid is an efficacious medication for the treatment of drug-resistant tuberculosis but has been associated with serious safety issues that can result in treatment interruption. The objectives of this study were thus to build a population pharmac
Externí odkaz:
https://doaj.org/article/610cde62416941eb9c0f796f9ffdb1e0
Autor:
Rob C. van Wijk, Laurynas Mockeliunas, Gerben van den Hoogen, Caryn M. Upton, Andreas H. Diacon, Ulrika S. H. Simonsson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Large clinical trials often generate complex and large datasets which need to be presented frequently throughout the trial for interim analysis or to inform a data safety monitory board (DSMB). In addition, reliable and traceability are requ
Externí odkaz:
https://doaj.org/article/023c5617c71b47638f55d07767493179
Autor:
Rob C. vanWijk, Laurynas Mockeliunas, Caryn M. Upton, Jonathan Peter, Andreas H. Diacon, Ulrika S. H. Simonsson
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 9, Pp 1250-1261 (2023)
Abstract Respiratory tract infections (RTIs) are a burden to global health, but their characterization is complicated by the influence of seasonality on incidence and severity. The Re‐BCG‐CoV‐19 trial (NCT04379336) assessed BCG (re)vaccination
Externí odkaz:
https://doaj.org/article/990494102e934b25ad6b9c6a0f758109
Autor:
Violeta Kleizaitė, Tatjana Čėsnienė, Ričardas Taraškevičius, Laurynas Mockeliūnas, Kristina Mak, Donatas Žvingila, Skaistė Bondzinskaitė, Asta Stapulionytė, Raimondas Šiukšta
Publikováno v:
Environmental science and pollution research international. 26(1)
Numerous investigations have demonstrated that even soil in which concentrations of individual elements do not exceed permissible limits can cause harmful effects in living organisms. In the present study, polluted-soil-induced oxidative stress was e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e812493b988478453187385c8b3715d
https://pubmed.ncbi.nlm.nih.gov/30276686
https://pubmed.ncbi.nlm.nih.gov/30276686
Autor:
Laurynas Mockeliunas, Rob C. van Wijk, Caryn M. Upton, Jonathan Peter, Andreas H. Diacon, Ulrika S. H. Simonsson
Publikováno v:
Vaccines, Vol 12, Iss 3, p 329 (2024)
(1) Background: Some individuals are more susceptible to developing respiratory tract infections (RTIs) or coronavirus disease (COVID-19) than others. The aim of this work was to identify risk factors for symptomatic RTIs including COVID-19 and sympt
Externí odkaz:
https://doaj.org/article/0c7e1a101744446f977319a9da3048a5
Autor:
Laurynas Mockeliunas, Alan Faraj, Rob C. van Wijk, Caryn M. Upton, Gerben van den Hoogen, Andreas H. Diacon, Ulrika S. H. Simonsson
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: A critical step in tuberculosis (TB) drug development is the Phase 2a early bactericidal activity (EBA) study which informs if a new drug or treatment has short-term activity in humans. The aim of this work was to present a standardized p
Externí odkaz:
https://doaj.org/article/0a767df0e5414983ab94bc69ae08d21a
Autor:
Lina Keutzer, Laurynas Mockeliunas, Marieke G. G. Sturkenboom, Mathieu S. Bolhuis, Onno W. Akkerman, Ulrika S. H. Simonsson
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1575 (2023)
Long-term usage of linezolid can result in adverse events such as peripheral neuropathy, anemia and thrombocytopenia. Therapeutic drug monitoring data from 75 drug-resistant tuberculosis patients treated with linezolid were analyzed using a time-to-e
Externí odkaz:
https://doaj.org/article/141df131ff23475eb08c004706589575