Rapid hyperpolarization and purification of the metabolite fumarate in aqueous solution

Autor: John W. Blanchard, Laurynas Dagys, Dmitry Budker, Eleonora Cavallari, Malcolm H. Levitt, Gerd Buntkowsky, Maksim Tsukanov, Danila A. Barskiy, Alexander Pines, Francesca Reineri, Kerstin Münnemann, Stephan Knecht, Silvio Aime, James Eills, Erik van Dyke, Peter Blümler, Bea Bliemel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America 118(13), e2025383118 (2021). doi:10.1073/pnas.2025383118
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 13
Proceedings of the National Academy of Sciences
chemRxiv
Proceedings of the National Academy of Sciences of the United States of America

Significance Magnetic resonance imaging is hindered by inherently low sensitivity, which limits the method for the most part to observing water molecules in the body. Hyperpolarized molecules exhibit strongly enhanced MRI signals which opens the door

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ca142476cf51bdb28120de5a884a2c

Deuteron‐Decoupled Singlet NMR in Low Magnetic Fields: Application to the Hyperpolarization of Succinic Acid**

Autor: Laurynas Dagys, Christian Bengs, Gamal A. I. Moustafa, Malcolm H. Levitt

Publikováno v: ChemPhysChem. 23

The reaction of unsaturated substrates with hydrogen gas enriched in the para spin isomer leads to products with a high degree of nuclear singlet spin order. This leads to greatly enhanced NMR signals, with important potential applications such as ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a03e2f79be1b3e56aab468a2d837cfc
https://doi.org/10.1002/cphc.202200274

Nuclear hyperpolarization of (1-13C)-pyruvate in aqueous solution by proton-relayed side-arm hydrogenation

Autor: Salvatore Mamone, Anil P. Jagtap, Philip Saul, Malcolm H. Levitt, Sergey Korchak, Laurynas Dagys, Stefan Glöggler

Publikováno v: Analyst

We employ Parahydrogen Induced Polarization with Side-Arm Hydrogenation (PHIP-SAH) to polarize (1-13C)-pyruvate. We introduce a new method called proton-relayed side-Arm hydrogenation (PR-SAH) in which an intermediate proton is used to transfer polar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece6aab0e6b6b276c41ff184e4c5355a
https://doi.org/10.1039/d0an02389b

Direct Production of a Hyperpolarized Metabolite on a Microfluidic Chip

Autor: Sylwia J. Barker, Laurynas Dagys, William Hale, Barbara Ripka, James Eills, Manvendra Sharma, Malcolm H. Levitt, Marcel Utz

Publikováno v: Analytical Chemistry

Microfluidic systems hold great potential for the study of live microscopic cultures of cells, tissue samples, and small organisms. Integration of hyperpolarisation would enable quantitative studies of metabolism in such volume limited systems by hig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a787c1837cf42fe608bb4005f7cbbf
https://pubmed.ncbi.nlm.nih.gov/35147413

Solid-State NMR and Impedance Spectroscopy Study of Spin Dynamics in Proton-Conducting Polymers: An Application of Anisotropic Relaxing Model

Autor: Vladimir I. Chizhik, Kestutis Aidas, Laurynas Dagys, Vaidas Klimkevičius, Vytautas Klimavicius, Juras Banys, Sergejus Balciunas, Vytautas Balevicius, Dovilė Lengvinaitė

Publikováno v: The Journal of Physical Chemistry. B

The 1H–13C cross-polarization (CP) kinetics in poly[2-(methacryloyloxy)ethyltrimethylammonium chloride] (PMETAC) was studied under moderate (10 kHz) magic-angle spinning (MAS). To elucidate the role of adsorbed water in spin diffusion and proton co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef51b7f5db4770a6664e412626f0d73
https://pubmed.ncbi.nlm.nih.gov/34748346