Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice

Autor: Holger Henneicke, Sarah Kim, Michael M. Swarbrick, Jingbao Li, Sylvia J. Gasparini, Joanne Thai, Daphne Foong, Lauryn L. Cavanagh, Colette Fong-Yee, Elisabeth Karsten, Ruby C.Y. Lin, Mark S. Cooper, Hong Zhou, Markus J. Seibel

Publikováno v: Molecular Metabolism, Vol 42, Iss , Pp 101098- (2020)

Objective: Aging and chronic glucocorticoid excess share a number of critical features, including the development of central obesity, insulin resistance and osteoporosis. Previous studies have shown that skeletal glucocorticoid signalling increases w

Externí odkaz: https://doaj.org/article/476d489ea49a45f7a0699ebe4bb2d015

Androgens sensitise mice to glucocorticoid-induced insulin resistance and fat accumulation

Autor: Hong Zhou, Sarah Kim, Lee J Thai, Marie-Christin Weber, Markus J. Seibel, Lauryn L. Cavanagh, Jinwen Tu, Sylvia J. Gasparini, Holger Henneicke, Michael M. Swarbrick

Publikováno v: Diabetologia. 62:1463-1477

Chronic glucocorticoid therapy causes insulin resistance, dyslipidaemia, abnormal fat accumulation, loss of muscle mass and osteoporosis. Here we describe a hitherto unknown sexual dimorphism in the metabolic response to chronic glucocorticoid exposu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ffcc32363f4930e640855a2ab4ad9b
https://doi.org/10.1007/s00125-019-4887-0

Deletion of the chondrocyte glucocorticoid receptor attenuates cartilage degradation through suppression of early synovial activation in murine posttraumatic osteoarthritis.

Autor: Macfarlane E; Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia. Electronic address: eugenie.macfarlane@anzac.edu.au., Cavanagh L; Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia. Electronic address: lauryn.cavanagh@sydney.edu.au., Fong-Yee C; Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia. Electronic address: colette.fong-yee@sydney.edu.au., Tuckermann J; Institute of Comparative Molecular Endocrinology, University of Ulm, Ulm, Baden-Württemberg, Germany. Electronic address: jan.tuckermann@uni-ulm.de., Chen D; Research Center for Human Tissues and Organs Degeneration, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China. Electronic address: di.chen@siat.ac.cn., Little CB; Raymond Purves Laboratories, Kolling Institute and Institute of Bone and Joint Research, University of Sydney, and Royal North Shore Hospital, St. Leonards, NSW, Australia. Electronic address: christopher.little@sydney.edu.au., Seibel MJ; Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia; Department of Endocrinology and Metabolism, Concord Repatriation General Hospital, Sydney, NSW, Australia. Electronic address: markus.seibel@sydney.edu.au., Zhou H; Bone Research Program, ANZAC Research Institute, University of Sydney, Sydney, NSW, Australia. Electronic address: h.zhou@sydney.edu.au.

Publikováno v: Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2023 Sep; Vol. 31 (9), pp. 1189-1201. Date of Electronic Publication: 2023 Apr 25.