Excess vitamin a might contribute to submucous clefting by inhibiting WNT ‐mediated bone formation

Autor: Charlotte Lucienne Jacqueline Maria Krutzen, Laury A. Roa, Marjon Bloemen, Johannes W. Von den Hoff

Publikováno v: Orthodontics and Craniofacial Research, 26, 1, pp. 132-139
Orthodontics & Craniofacial Research, 26(1), 132-139. Wiley-Blackwell
Orthodontics and Craniofacial Research, 26, 132-139

Contains fulltext : 291236.pdf (Publisher’s version ) (Open Access) OBJECTIVES: Cleft lip and/or palate (CLP) is a common craniofacial birth defect caused by genetic as well as environmental factors. The phenotypic spectrum of CLP also includes sub

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d13e4bd8a3e560f1c1a3b6176dcf80
https://doi.org/10.1111/ocr.12594

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Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis

Autor: Michelle Thonissen, Marloes Steehouwer, Maartje van de Vorst, K Dreesen, Shalini N. Jhangiani, Carine Carels, Han G. Brunner, Marjon Bloemen, Vincent Vander Poorten, Joep de Ligt, Elisabeth Mangold, Christian Gilissen, Charlotte W. Ockeloen, Joseph Schoenaers, Ellen van Beusekom, Nina Ishorst, Federica Conte, Rolph Pfundt, Tjitske Kleefstra, Robert Sullivan, Huiqing Zhou, Lisenka E.L.M. Vissers, Anna Verdonck, Iris A.L.M. van Rooij, Johannes W. Von den Hoff, Kriti D. Khandelwal, Arjen Henkes, Koenraad Devriendt, Alexander Hoischen, Bruno Vankeirsbilck, Milien Phan, Nel Roeleveldt, Greet Hens, James R. Lupski, Jasmien Roosenboom, Steven Swinnen, Stefaan J. Bergé, Hans van Bokhoven, Kerstin U. Ludwig, Laury A Roa Fuentes, Michael J. Dixon, Jill Dixon

Publikováno v: Genetics in Medicine, 18, 11, pp. 1158-1162
Genetics in Medicine, 18(11), 1158. Lippincott Williams and Wilkins
Genetics in medicine : official journal of the American College of Medical Genetics
Genetics in Medicine, 18, 1158-1162

Contains fulltext : 165724.pdf (Publisher’s version ) (Open Access) PURPOSE: We aimed to identify a novel genetic cause of tooth agenesis (TA) and/or orofacial clefting (OFC) by combining whole-exome sequencing (WES) and targeted resequencing in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5e2c78055fa8f0e3492994b5a4e48e8
https://hdl.handle.net/2066/165724

Excess vitamin a might contribute to submucous clefting by inhibiting WNT-mediated bone formation.

Autor: Krutzen CLJM; Department of Dentistry - Orthodontics and Craniofacial Biology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Roa LA; Department of Dentistry - Orthodontics and Craniofacial Biology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.; Laury A. Roa, Department of Instructive Biomaterial Engineering (IBE), MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands., Bloemen M; Department of Dentistry - Orthodontics and Craniofacial Biology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands., Von den Hoff JW; Department of Dentistry - Orthodontics and Craniofacial Biology, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands.

Publikováno v: Orthodontics & craniofacial research [Orthod Craniofac Res] 2023 Feb; Vol. 26 (1), pp. 132-139. Date of Electronic Publication: 2022 Jun 28.