Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Laurits Fredsgaard"'
Autor:
Cyrielle Fougeroux, Louise Goksøyr, Manja Idorn, Vladislav Soroka, Sebenzile K. Myeni, Robert Dagil, Christoph M. Janitzek, Max Søgaard, Kara-Lee Aves, Emma W. Horsted, Sayit Mahmut Erdoğan, Tobias Gustavsson, Jerzy Dorosz, Stine Clemmensen, Laurits Fredsgaard, Susan Thrane, Elena E. Vidal-Calvo, Paul Khalifé, Thomas M. Hulen, Swati Choudhary, Michael Theisen, Susheel K. Singh, Asier Garcia-Senosiain, Linda Van Oosten, Gorben Pijlman, Bettina Hierzberger, Tanja Domeyer, Blanka W. Nalewajek, Anette Strøbæk, Magdalena Skrzypczak, Laura F. Andersson, Søren Buus, Anette Stryhn Buus, Jan Pravsgaard Christensen, Tim J. Dalebout, Kasper Iversen, Lene H. Harritshøj, Benjamin Mordmüller, Henrik Ullum, Line S. Reinert, Willem Adriaan de Jongh, Marjolein Kikkert, Søren R. Paludan, Thor G. Theander, Morten A. Nielsen, Ali Salanti, Adam F. Sander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Here the authors generate a capsid-like particle based vaccine candidate displaying the receptor-binding domain of the SARS-CoV-2 spike protein and show induction of neutralizing antibodies after intramuscular prime-boost immunization in mice.
Externí odkaz:
https://doaj.org/article/c047e4469bfc4df49317bf7ddb5a7a95
Autor:
Laurits Fredsgaard, Louise Goksøyr, Susan Thrane, Kara-Lee Aves, Thor G. Theander, Adam F. Sander
Publikováno v:
Vaccines, Vol 9, Iss 6, p 539 (2021)
Capsid virus-like particles (cVLPs) are used as molecular scaffolds to increase the immunogenicity of displayed antigens. Modular platforms have been developed whereby antigens are attached to the surface of pre-assembled cVLPs. However, it remains u
Externí odkaz:
https://doaj.org/article/2b843aab3b604773a0cd5c0b1cf6c41c
Autor:
Robert Dagil, Gorben P. Pijlman, Søren R. Paludan, Susan Thrane, Anette Strøbæk, Tim J. Dalebout, Blanka W. Nalewajek, Tanja Domeyer, Laura F. Andersson, Sebenzile K. Myeni, Susheel K. Singh, Anette Stryhn Buus, Michael Theisen, Vladislav Soroka, Thomas M. Hulen, Søren Buus, Emma W. Horsted, Stine B. Clemmensen, Thor G. Theander, Laurits Fredsgaard, Cyrielle Fougeroux, Magdalena Skrzypczak, Ali Salanti, Benjamin Mordmüller, Manja Idorn, Louise Goksøyr, Kasper Iversen, Max Søgaard, Jerzy Dorosz, Asier Garcia-Senosiain, Sayit Mahmut Erdoğan, Line S. Reinert, Tobias Gustavsson, Morten Nielsen, Lene Holm Harritshøj, Bettina Hierzberger, Marjolein Kikkert, Henrik Ullum, Paul Khalifé, Swati Choudhary, Adam F. Sander, Kara Lee Aves, Christoph M. Janitzek, Willem A. de Jongh, Elena Ethel Vidal-Calvo, Jan Pravsgaard Christensen, Linda van Oosten
Publikováno v:
Nature Communications 12 (2021) 1
Nature Communications
Nature Communications, 12(1)
Nature Communications, 12(1). NATURE RESEARCH
Fougeroux, C, Goksøyr, L, Idorn, M, Soroka, V, Myeni, S K, Dagil, R, Janitzek, C M, Søgaard, M, Aves, K-L, Horsted, E W, Erdogan, S M, Gustavsson, T, Dorosz, J, Clemmensen, S, Fredsgaard, L, Thrane, S, Vidal-Calvo, E E, Khalifé, P, Hulen, T M, Choudhary, S, Theisen, M, Singh, S K, Garcia-Senosiain, A, Van Oosten, L, Pijlman, G, Hierzberger, B, Domeyer, T, Nalewajek, B W, Strøbæk, A, Skrzypczak, M, Andersson, L F, Buus, S, Buus, A S, Christensen, J P, Dalebout, T J, Iversen, K, Harritshøj, L H, Mordmüller, B, Ullum, H, Reinert, L S, de Jongh, W A, Kikkert, M, Paludan, S R, Theander, T G, Nielsen, M A, Salanti, A & Sander, A F 2021, ' Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity ', Nature Communications, vol. 12, no. 1, pp. 324 . https://doi.org/10.1038/s41467-020-20251-8
Fougeroux, C, Goksøyr, L, Idorn, M, Soroka, V, Myeni, S K, Dagil, R, Janitzek, C M, Søgaard, M, Aves, K L, Horsted, E W, Erdoğan, S M, Gustavsson, T, Dorosz, J, Clemmensen, S, Fredsgaard, L, Thrane, S, Vidal-Calvo, E E, Khalifé, P, Hulen, T M, Choudhary, S, Theisen, M, Singh, S K, Garcia-Senosiain, A, Van Oosten, L, Pijlman, G, Hierzberger, B, Domeyer, T, Nalewajek, B W, Strøbæk, A, Skrzypczak, M, Andersson, L F, Buus, S, Buus, A S, Christensen, J P, Dalebout, T J, Iversen, K, Harritshøj, L H, Mordmüller, B, Ullum, H, Reinert, L S, de Jongh, W A, Kikkert, M, Paludan, S R, Theander, T G, Nielsen, M A, Salanti, A & Sander, A F 2021, ' Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity ', Nature Communications, vol. 12, no. 1, 324 . https://doi.org/10.1038/s41467-020-20251-8
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications, 12(1)
Nature Communications, 12(1). NATURE RESEARCH
Fougeroux, C, Goksøyr, L, Idorn, M, Soroka, V, Myeni, S K, Dagil, R, Janitzek, C M, Søgaard, M, Aves, K-L, Horsted, E W, Erdogan, S M, Gustavsson, T, Dorosz, J, Clemmensen, S, Fredsgaard, L, Thrane, S, Vidal-Calvo, E E, Khalifé, P, Hulen, T M, Choudhary, S, Theisen, M, Singh, S K, Garcia-Senosiain, A, Van Oosten, L, Pijlman, G, Hierzberger, B, Domeyer, T, Nalewajek, B W, Strøbæk, A, Skrzypczak, M, Andersson, L F, Buus, S, Buus, A S, Christensen, J P, Dalebout, T J, Iversen, K, Harritshøj, L H, Mordmüller, B, Ullum, H, Reinert, L S, de Jongh, W A, Kikkert, M, Paludan, S R, Theander, T G, Nielsen, M A, Salanti, A & Sander, A F 2021, ' Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity ', Nature Communications, vol. 12, no. 1, pp. 324 . https://doi.org/10.1038/s41467-020-20251-8
Fougeroux, C, Goksøyr, L, Idorn, M, Soroka, V, Myeni, S K, Dagil, R, Janitzek, C M, Søgaard, M, Aves, K L, Horsted, E W, Erdoğan, S M, Gustavsson, T, Dorosz, J, Clemmensen, S, Fredsgaard, L, Thrane, S, Vidal-Calvo, E E, Khalifé, P, Hulen, T M, Choudhary, S, Theisen, M, Singh, S K, Garcia-Senosiain, A, Van Oosten, L, Pijlman, G, Hierzberger, B, Domeyer, T, Nalewajek, B W, Strøbæk, A, Skrzypczak, M, Andersson, L F, Buus, S, Buus, A S, Christensen, J P, Dalebout, T J, Iversen, K, Harritshøj, L H, Mordmüller, B, Ullum, H, Reinert, L S, de Jongh, W A, Kikkert, M, Paludan, S R, Theander, T G, Nielsen, M A, Salanti, A & Sander, A F 2021, ' Capsid-like particles decorated with the SARS-CoV-2 receptor-binding domain elicit strong virus neutralization activity ', Nature Communications, vol. 12, no. 1, 324 . https://doi.org/10.1038/s41467-020-20251-8
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The rapid development of a SARS-CoV-2 vaccine is a global priority. Here, we develop two capsid-like particle (CLP)-based vaccines displaying the receptor-binding domain (RBD) of the SARS-CoV-2 spike protein. RBD antigens are displayed on AP205 CLPs