Direct Aminoalkylation of Arenes, Heteroarenes, and Alkenes via Ni-Catalyzed Negishi Cross-Coupling Reactions

Autor: Paul Knochel, Laurin Melzig, Andrey Gavryushin, Teresa Dennenwaldt

Publikováno v: The Journal of Organic Chemistry. 76:8891-8906

A room-temperature Ni-catalyzed cross-coupling of aryl, heteroaryl, and alkenyl electrophiles with aminoalkylzinc bromides, readily available from the corresponding aminoalkyl chlorides via Grignard reagents, was developed. The reaction allows a conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a78bb352338014605345dc4009bcac0
https://doi.org/10.1021/jo201630e

Scaled-Up Transition-Metal-Catalyzed Cross-Coupling Reactions of Thioether-Substituted N-Heterocycles with Organozinc Reagents

Autor: Paul Knochel, Albrecht Metzger, Laurin Melzig

Publikováno v: Synthesis. 2010:2853-2858

A variety of functionalized methylthio-substituted N-heterocycles (pyridines, pyrimidines, pyrazines, pyridazines, triazines, quinazolines, benzothiazoles) undergo smooth palladium- or nickel-catalyzed cross-couplings with highly functionalized organ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2cd3e1d038c39a78320e07d8ef850cfb
https://doi.org/10.1055/s-0030-1258145

Pd-Catalyzed Cross-Coupling of Functionalized Organozinc Reagents with Thiomethyl-Substituted Heterocycles

Autor: Paul Knochel, Albrecht Metzger, Christina Despotopoulou, Laurin Melzig

Publikováno v: Organic Letters. 11:4228-4231

Various thiomethyl-substituted N-heterocycles (pyridines, pyrimidines, pyrazines, pyridazines, triazines, benzothiazoles, benzoxazoles, pyrazoles, benzindazoles, quinazolines, etc.) undergo smooth Pd-catalyzed cross-coupling reactions with functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f6ab59a9e49b250c9a306ba526b322
https://doi.org/10.1021/ol9017003

Meta- and Para-Difunctionalization of Arenes via a Sulfoxide−Magnesium Exchange Reaction

Autor: Laurin Melzig, Christian B. Rauhut, Paul Knochel

Publikováno v: Organic Letters. 10:3891-3894

The aryl sulfoxide moiety (ArSO) allows an expedient two-step meta-, para-difunctionalization of readily available diaryl sulfoxides. In the first step, the sulfoxide plays the role of a directing metalation group. In the second step, triggered by i-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b99ae4a3faab41e625d75cdb30e4649
https://doi.org/10.1021/ol801431z

Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors

Autor: Guillermo Moreno-Sanz, Tiziano Bandiera, Andrea Tontini, Claudio Fiorelli, Andrea Duranti, Gian Filippo Ruda, Giorgio Tarzia, Marco Mor, Laurin Melzig, Giampiero Colombano, Silvano Sanchini, Rita Scarpelli, Paola Mestichelli, Daniele Piomelli

Publikováno v: Moreno-Sanz, G; Duranti, A; Melzig, L; Fiorelli, C; Ruda, GF; Colombano, G; et al.(2013). Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors. Journal of Medicinal Chemistry, 56(14), 5917-5930. doi: 10.1021/jm4007017. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/58n791jz

The peripherally restricted fatty acid amide hydrolase (FAAH) inhibitor URB937 (3, cyclohexylcarbamic acid 3′-carbamoyl-6-hydroxybiphenyl-3-yl ester) is extruded from the brain and spinal cord by the Abcg2 efflux transporter. Despite its inability

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb57f23a634d4af38f43c24623bb104
http://www.escholarship.org/uc/item/58n791jz