Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Laurin M. Hanft"'
Autor:
Andrew Behrmann, Jessica Cayton, Matthew R. Hayden, Michelle D. Lambert, Zahra Nourian, Keith Nyanyo, Brooke Godbee, Laurin M. Hanft, Maike Krenz, Kerry S. McDonald, Timothy L. Domeier
Publikováno v:
Physiological Reports, Vol 12, Iss 8, Pp n/a-n/a (2024)
Abstract Duchenne muscular dystrophy (DMD) is an X‐linked recessive myopathy due to mutations in the dystrophin gene. Diaphragmatic weakness in DMD causes hypoventilation and elevated afterload on the right ventricle (RV). Thus, RV dysfunction in D
Externí odkaz:
https://doaj.org/article/8bd18aada0dc4d288ec501a262f7675c
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Dystrophic cardiomyopathy arises from mutations in the dystrophin gene. Dystrophin forms part of the dystrophin glycoprotein complex and is postulated to act as a membrane stabilizer, protecting the sarcolemma from contraction-induced damage. Duchenn
Externí odkaz:
https://doaj.org/article/1c307c6275ae491985e639d9bdd75ec6
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Heart failure (HF) often includes changes in myocardial contractile function. This study addressed the myofibrillar basis for contractile dysfunction in failing human myocardium. Regulation of contractile properties was measured in cardiac myocyte pr
Externí odkaz:
https://doaj.org/article/10c2f29f3e5a44d6a0b35ea5949c93bc
Publikováno v:
Biochemistry Research International, Vol 2012 (2012)
In healthy hearts, ventricular ejection is determined by three myofibrillar properties; force, force development rate, and rate of loaded shortening (i.e., power). The sarcomere length and PKA dependence of these mechanical properties were measured i
Externí odkaz:
https://doaj.org/article/aece3ee099994d6d8a68d783262f5c4c
Publikováno v:
American journal of physiology. Cell physiology. 323(6)
Stretch activation is defined as a delayed increase in force after rapid stretches. Although there is considerable evidence for stretch activation in isolated cardiac myofibrillar preparations, few studies have measured mechanisms of stretch activati
Autor:
Laurin M. Hanft, Joel C. Robinett, Theodore J. Kalogeris, Kenneth S. Campbell, Brandon J. Biesiadecki, Kerry S. McDonald
Publikováno v:
Journal of General Physiology. 155
The heart’s pumping capacity is determined by myofilament power generation. Power is work done per unit time and measured as the product of force and velocity. At a sarcomere level, these contractile properties are linked to the number of attached
Autor:
Laurin M. Hanft, Theodore J. Kalogeris, Kenneth S. Campbell, Brandon J. Biesiadecki, Kerry S. McDonald
Publikováno v:
Biophysical Journal. 122:120a-121a
Autor:
Christopher P. Baines, Maike Krenz, Dongsheng Duan, Laurin M. Hanft, Vivian Onyali, Kerry S. McDonald, Timothy L. Domeier, Zahra Nourian
Publikováno v:
The FASEB Journal. 35
Autor:
Kerry S. McDonald, Laurin M. Hanft
Publikováno v:
Arch Biochem Biophys
Autor:
Aikaterini Kontrogianni-Konstantopoulos, Laurin M. Hanft, Kerry S. McDonald, Joel C. Robinett, Janelle Geist
Publikováno v:
The Journal of General Physiology
Myosin binding protein C (MyBP-C) is thought to regulate the contraction of skeletal muscle. Robinett et al. show that phosphorylation of slow skeletal MyBP-C modulates contraction by recruiting cross-bridges, modifying cross-bridge kinetics, and alt