Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Laurin Flemmich"'
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 2295-2301 (2021)
A naturally occurring riboswitch can utilize 7-aminomethyl-O6-methyl-7-deazaguanine (m6preQ1) as cofactor for methyl group transfer resulting in cytosine methylation. This recently discovered riboswitch-ribozyme activity opens new avenues for the dev
Externí odkaz:
https://doaj.org/article/49d70d29e9df45e4953b33ca54903686
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
In humans, protein methyltransferase is responsible for RNA methylation using S-adenosylmethionine as a methyl group donor. Here the authors report a self-methylation activity of a bacterial riboswitch.
Externí odkaz:
https://doaj.org/article/810fbaf44cfa46af9616a8b0edf1ebc5
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 153:285-291
The growing interest in 3-methylcytidine (m3C) originates from the recent discoveries of m3C modified tRNAs in humans as well as its intensively debated occurrence in mRNA. Moreover, m3C formation can be catalyzed by RNA without the assistance of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5746530c7457f970f132e90a3326902
https://doi.org/10.1007/s00706-022-02896-x
https://doi.org/10.1007/s00706-022-02896-x
Autor:
Larissa Bessler, Navpreet Kaur, Lea-Marie Vogt, Laurin Flemmich, Carmen Siebenaller, Marie-Luise Winz, Francesca Tuorto, Ronald Micura, Ann E Ehrenhofer-Murray, Mark Helm
Publikováno v:
Nucleic acids research. 50(18)
Substitution of the queuine nucleobase precursor preQ1 by an azide-containing derivative (azido-propyl-preQ1) led to incorporation of this clickable chemical entity into tRNA via transglycosylation in vitro as well as in vivo in Escherichia coli, Sch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260857f539f2ae8de9afedd7738c5729
https://pubmed.ncbi.nlm.nih.gov/36169220
https://pubmed.ncbi.nlm.nih.gov/36169220
Autor:
Egor A. Syroegin, Laurin Flemmich, Dorota Klepacki, Nora Vazquez-Laslop, Ronald Micura, Yury S. Polikanov
Publikováno v:
Nat Struct Mol Biol
Ribosome-targeting antibiotics serve as powerful antimicrobials and as tools for studying the ribosome, the catalytic peptidyl transferase center (PTC) of which is targeted by many drugs. The classic PTC-acting antibiotic chloramphenicol (CHL) and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baec779b058957314915defbfc42a2e8
https://europepmc.org/articles/PMC9071271/
https://europepmc.org/articles/PMC9071271/
Publikováno v:
Monatshefte fur chemie. 153(3)
The growing interest in 3-methylcytidine (mThe online version contains supplementary material available at 10.1007/s00706-022-02896-x.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e85e5980b609bb3413a57f91b5bc9eda
https://pubmed.ncbi.nlm.nih.gov/35400759
https://pubmed.ncbi.nlm.nih.gov/35400759
Autor:
Laurin Flemmich, Egor A Syroegin, Ronald Micura, Yury S. Polikanov, Nora Vázquez-Laslop, Dorota Klepacki
Ribosome-targeting antibiotics serve both as powerful antimicrobials and as tools for studying the ribosome. The ribosomal catalytic site, the peptidyl transferase center (PTC), is targeted by a large number of various drugs. The classical and best-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f614ad5a7e86cf43db5419c59b2bcab3
https://doi.org/10.1101/2021.06.17.448903
https://doi.org/10.1101/2021.06.17.448903
Autor:
Hao, Chen, Michaela, Egger, Xiaochen, Xu, Laurin, Flemmich, Olga, Krasheninina, Aiai, Sun, Ronald, Micura, Aiming, Ren
Publikováno v:
Nucleic Acids Research
Riboswitches are important gene regulatory elements frequently encountered in bacterial mRNAs. The recently discovered nadA riboswitch contains two similar, tandemly arrayed aptamer domains, with the first domain possessing high affinity for nicotina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8f7b84b116cb5b9024b8dbd53491c1a
https://pubmed.ncbi.nlm.nih.gov/33170270
https://pubmed.ncbi.nlm.nih.gov/33170270
Publikováno v:
Organic letters. 21(11)
3-Deazaguanosine (c3G) and phosphoramidite derivatives thereof that allow incorporation of this modification into RNA are needed for atomic mutagenesis experiments to explore mechanistic aspects of ribozyme catalysis. Here, we report a practical synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5299a3135188a16269b4df5d10457403
https://pubmed.ncbi.nlm.nih.gov/31081638
https://pubmed.ncbi.nlm.nih.gov/31081638