Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation.

Autor: Laurie-Anne Payet, Linette Kadri, Sébastien Giraud, Caroline Norez, Jean Marc Berjeaud, Christophe Jayle, Sandra Mirval, Frédéric Becq, Clarisse Vandebrouck, Thierry Ferreira

Publikováno v: PLoS ONE, Vol 9, Iss 2, p e89044 (2014)

The F508del-CFTR mutation, responsible for Cystic Fibrosis (CF), leads to the retention of the protein in the endoplasmic reticulum (ER). The mistrafficking of this mutant form can be corrected by pharmacological chaperones, but these molecules showe

Externí odkaz: https://doaj.org/article/143433953bb645d0a8948d6413be1f71

Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins

Autor: Sandra Lacas-Gervais, Sophie Pagnotta, Romain Gautier, Mathieu Pinot, Bruno Goud, Stefano Vanni, Laurie-Anne Payet, Hélène Barelli, Bruno Antonny, Thierry Ferreira

Publikováno v: Science (New York N.Y.)

Bending the benefits of polyunsaturates We have often heard that it is beneficial to eat polyunsaturated fatty acids. We also know that some organelles such as synaptic vesicles are extremely rich in polyunsaturated lipids. However, what polyunsatura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbafa4fa8f5377ea81874e52fcaa9f9a
https://doi.org/10.1126/science.1255288

Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast

Autor: Fabien Pierrel, Akio Kihara, Mélanie Leroux, Ludovic Pelosi, Laurie Anne Payet, John C. Willison

Publikováno v: Cell Chemical Biology
Cell Chemical Biology, Cell Press, 2016, 23 (10), pp.1241-1250. ⟨10.1016/j.chembiol.2016.08.008⟩
Cell Chemical Biology, 2016, 23 (10), pp.1241-1250. ⟨10.1016/j.chembiol.2016.08.008⟩

International audience; Coenzyme Q (Q) is a redox lipid that is central for the energetic metabolism of eukaryotes. The biosynthesis of Q from the aromatic precursor 4-hydroxybenzoic acid (4-HB) is understood fairly well. However, biosynthetic detail

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::441ada84622e0b41390898f569ec33be
https://pubmed.ncbi.nlm.nih.gov/27732833

Cystic fibrosis bronchial epithelial cells are lipointoxicated by membrane palmitate accumulation

Autor: Sébastien Giraud, Jean Marc Berjeaud, Frédéric Becq, Linette Kadri, Caroline Norez, Sandra Mirval, Laurie-Anne Payet, Christophe Jayle, Clarisse Vandebrouck, Thierry Ferreira

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2014, 9 (2), pp.e89044. ⟨10.1371/journal.pone.0089044⟩
PLoS ONE, Vol 9, Iss 2, p e89044 (2014)

International audience; The F508del-CFTR mutation, responsible for Cystic Fibrosis (CF), leads to the retention of the protein in the endoplasmic reticulum (ER). The mistrafficking of this mutant form can be corrected by pharmacological chaperones, b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfbbb40da08f03cca06a5adaf67a814
https://hal.archives-ouvertes.fr/hal-00990346

Lipid cell biology. Polyunsaturated phospholipids facilitate membrane deformation and fission by endocytic proteins

Autor: mathieu Pinot, Stefano Vanni, Sophie Pagnotta, Sandra Lacas-Gervais, Laurie-Anne Payet, Thierry Ferreira, Romain Gautier, Bruno Goud, Bruno Antonny, Hélène Barelli

Publikováno v: HAL

Phospholipids (PLs) with polyunsaturated acyl chains are extremely abundant in a few specialized cellular organelles such as synaptic vesicles and photoreceptor discs, but their effect on membrane properties is poorly understood. Here, we found that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::debb7c4490032d3e7287e09b8d6d1f39
https://hal.archives-ouvertes.fr/hal-01141794