Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Laurie Kenvin"'
Autor:
Laurie Kenvin, Ji-Hyun Lee, Shalaka S. Hampras, Kenneth H. Shain, William J. Fulp, Rami S. Komrokji, Martha Olesnyckyj, Najla Al Ali, Alan F. List, Jeffrey E. Lancet, Kate Fisher, Robert Knight, William S. Dalton, Dana E. Rollison, Qiang Xu, Eric Padron
Publikováno v:
Cancer Medicine
The few studies that have examined rates of acute myeloid leukemia (AML) transformation in lenalidomide‐treated myelodysplastic syndrome (MDS) patients have been limited to deletion 5q MDS. The association between lenalidomide and subsequent primar
Subsequent primary malignancies among multiple myeloma patients treated with or without lenalidomide
Autor:
Rami S. Komrokji, Rachid Baz, William S. Dalton, Robert Knight, Shalaka S. Hampras, Ji-Hyun Lee, Melissa Alsina, Laurie Kenvin, Taiga Nishihori, Daniel M. Sullivan, Qiang Xu, Marta Olesnyckyj, Dana E. Rollison, William J. Fulp, Kate Fisher, Kenneth H. Shain
Publikováno v:
Leuk Lymphoma
Risk of subsequent primary malignancies (SPMs) associated with lenalidomide therapy in multiple myeloma (MM) patients, outside the context of melphalan-based therapy is not established. We assessed the risk of SPMs in lenalidomide treated MM patients
Autor:
Jane Jie Lu, James W. Hardin, Jayesh Mehta, Yasir Nagarwala, Laurie Kenvin, Mohit Narang, Robert M. Rifkin, Robert Knight, Howard R. Terebelo, Brian G.M. Durie, Kathleen Toomey, Shankar Srinivasan, Jatin J. Shah, Cristina Gasparetto, Rafat Abonour
Publikováno v:
Leukemialymphoma. 57(9)
Advances in treatment have extended the survival of patients with multiple myeloma (MM),[1] but this increased survival time also increases the potential for developing second primary malignancies ...
Autor:
Ira Gupta, Irina Kline, Courtney D. DiNardo, Eyal C. Attar, Laurie Kenvin, Eytan M. Stein, Ag C Study Investigators, Stéphane de Botton, Amir T. Fathi
Publikováno v:
JAMA Oncology. 4:1106
Importance Enasidenib mesylate, a mutant isocitrate dehydrogenase 2 (IDH2) protein inhibitor that promotes differentiation of leukemic myeloblasts, was recently approved by the US Food and Drug Administration for use in relapsed/refractory (R/R) muta
Autor:
Courtney D. DiNardo, Irina Kline, Laurie Kenvin, Ira Gupta, Eyal C. Attar, Stéphane de Botton, Eytan M. Stein, Amir T. Fathi
Publikováno v:
Journal of Clinical Oncology. 35:7015-7015
7015 Background: Enasidenib (AG-221), an oral mIDH2 inhibitor, promotes myeloid differentiation of leukemic blasts. Enasidenib treatment (Tx) can result in IDH-inhibitor-associated differentiation syndrome (IDH-DS), with manifestations akin to retino
Autor:
Robert Vescio, David Irwin, Stephanie F. Williams, Marta Olesnyckyj, Paul G. Richardson, Mohamad A. Hussein, William I. Bensinger, Seema Singhal, James R. Berenson, Jerome B. Zeldis, Zhinuan Yu, Robert Knight, Sundar Jagannath, Laurie Kenvin, Ashraf Badros, Kenneth C. Anderson
Publikováno v:
Blood. 114(4)
Lenalidomide plus dexamethasone is effective for the treatment of relapsed and refractory multiple myeloma (MM); however, toxicities from dexamethasone can be dose limiting. We evaluated the efficacy and safety of lenalidomide monotherapy in patients
Autor:
Jane Jie Lu, Cristina Gasparetto, Robert M. Rifkin, Kathleen Toomey, Mohit Narang, Rosanna J. Ricafort, Jatin J. Shah, Brian G.M. Durie, Jayesh Mehta, Howard R. Terebelo, Laurie Kenvin, Sachdev P. Thomas, Shankar Srinivasan, Rafat Abonour, James W. Hardin, Yasir Nagarwala
Publikováno v:
Blood. 124:4749-4749
Background: Increased rates of SPM have been observed as newer cancer treatments have improved survival over the past 2 decades (Fraumeni et al. NCI, 2006). Higher incidence of specific types of hematologic SPM following MM, especially acute myeloid
Autor:
Laurie Kenvin, Najla Al Ali, Marta Olesnyckyj, Ji-Hyun Lee, Shalaka S. Hampras, William S. Dalton, Eric Padron, Jeff E Lancet, Rami S. Komrokji, Kate Fisher, Robert Knight, Kenneth H. Shain, Dana E. Rollison, Alan F. List
Publikováno v:
Blood. 124:413-413
Introduction: Lenalidomide is approved by the FDA for treatment of transfusion-dependent, lower risk, deletion 5q (del(5q)) MDS patients and used widely in practice for non-del(5q) MDS patients with anemia. Recently, subsequent primary malignancies (
Subsequent Primary Malignancies Among Multiple Myeloma Patients Treated with or without Lenalidomide
Autor:
Rami S. Komrokji, Laurie Kenvin, William J. Fulp, Marta Olesnyckyj, Rachid Baz, Taiga Nishihori, Kenneth H. Shain, Robert Knight, Kate Fisher, William S. Dalton, Dana E. Rollison, Shalaka S. Hampras, Melissa Alsina, Ji-Hyun Lee, Daniel M. Sullivan
Publikováno v:
Blood. 124:2129-2129
Introduction: The incidence of subsequent primary malignancies (SPM) associated with lenalidomide treatment of multiple myeloma (MM) outside the context of maintenance therapy post-melphalan is unknown. Three clinical trials reported modest, statisti
Autor:
Robert Knight, Ruben Niesvizky, Christine Chen, David Irwin, Jerome B. Zeldis, Shaji Kumar, Jonathan Polikoff, Rafat Abonour, Richard A. Gams, David S. Siegel, Laurie Kenvin, Edward A. Stadtmauer, Dennis Pietronigro, Angela Hu, Dale McElveen, Ralph V. Boccia, Donna E. Reece
Publikováno v:
Blood. 108:3556-3556
Background: Lenalidomide (Revlimid®) in combination with dexamethasone was approved in the US on June 29, 2006 for the treatment of subjects with multiple myeloma who had received at least one prior therapy. On February 28, 2005 based upon a positiv