Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Laurie K, Svoboda"'
Autor:
Jade Schroeder, Katelyn M. Polemi, Anagha Tapaswi, Laurie K. Svoboda, Jonathan Z. Sexton, Justin A. Colacino
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionBreast cancer is the second most diagnosed cancer, as well as the primary cause of cancer death in women worldwide. Of the different breast cancer subtypes, triple-negative breast cancer (TNBC) is particularly aggressive and is associated
Externí odkaz:
https://doaj.org/article/3b86d6f5db97470c86be00564ad2be6d
Autor:
Rebekah L. Petroff, Dana C. Dolinoy, Kai Wang, Luke Montrose, Vasantha Padmanabhan, Karen E. Peterson, Douglas M. Ruden, Maureen A. Sartor, Laurie K. Svoboda, Martha M. Téllez-Rojo, Jaclyn M. Goodrich
Publikováno v:
Environment International, Vol 186, Iss , Pp 108575- (2024)
Although toxicology uses animal models to represent real-world human health scenarios, a critical translational gap between laboratory-based studies and epidemiology remains. In this study, we aimed to understand the toxicoepigenetic effects on DNA m
Externí odkaz:
https://doaj.org/article/250e66bb854f46d58bad6a02891c8046
Autor:
Rebekah L. Petroff, Raymond G. Cavalcante, Justin A. Colacino, Jaclyn M. Goodrich, Tamara R. Jones, Claudia Lalancette, Rachel K. Morgan, Kari Neier, Bambarendage P. U. Perera, Christine A. Rygiel, Laurie K. Svoboda, Kai Wang, Maureen A. Sartor, Dana C. Dolinoy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Introduction: The developing epigenome changes rapidly, potentially making it more sensitive to toxicant exposures. DNA modifications, including methylation and hydroxymethylation, are important parts of the epigenome that may be affected by environm
Externí odkaz:
https://doaj.org/article/5b930414f936410f8ed12f4473232a85
Autor:
Laurie K. Svoboda, Kari Neier, Kai Wang, Raymond G. Cavalcante, Christine A. Rygiel, Zing Tsai, Tamara R. Jones, Siyu Liu, Jaclyn M. Goodrich, Claudia Lalancette, Justin A. Colacino, Maureen A. Sartor, Dana C. Dolinoy
Publikováno v:
Epigenetics, Vol 16, Iss 10, Pp 1102-1122 (2021)
Early developmental environment can influence long-term health through reprogramming of the epigenome. Human environmental epigenetics studies rely on surrogate tissues, such as blood, to assess the effects of environment on disease-relevant but inac
Externí odkaz:
https://doaj.org/article/ba9c41a8e56a4e1794df3be4c666cf60
Autor:
Laurie K. Svoboda, Kai Wang, Jaclyn M. Goodrich, Tamara R. Jones, Justin A. Colacino, Karen E. Peterson, Martha M. Tellez-Rojo, Maureen A. Sartor, Dana C. Dolinoy
Publikováno v:
Toxics, Vol 11, Iss 1, p 85 (2023)
Environmental contaminants such as the metal lead (Pb) are associated with cardiovascular disease, but the underlying molecular mechanisms are poorly understood. In particular, little is known about how exposure to Pb during early development impacts
Externí odkaz:
https://doaj.org/article/2972c769fe584d8e8ebbf25f8da924f3
Autor:
Kai Wang, Siyu Liu, Laurie K. Svoboda, Christine A. Rygiel, Kari Neier, Tamara R. Jones, Justin A. Colacino, Dana C. Dolinoy, Maureen A. Sartor
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
Lead (Pb) is a well-known toxicant that interferes with the development of a child’s nervous and metabolic systems and increases the risk of developing diseases later in life. Although studies have investigated epigenetic effects associated with Pb
Externí odkaz:
https://doaj.org/article/8cacfd453a854541a3d19c94939a7758
Autor:
Bambarendage P. U. Perera, Rachel K. Morgan, Katelyn M. Polemi, Kimmie E. Sala-Hamrick, Laurie K. Svoboda, Dana C. Dolinoy
Publikováno v:
Current Environmental Health Reports. 9:650-660
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e6a09345c9911a37cada5bddc572c3b
https://doi.org/10.1007/s40572-022-00372-6
https://doi.org/10.1007/s40572-022-00372-6
Autor:
Maureen A. Malloy, Joseph J. Kochmanski, Tamara R. Jones, Justin A. Colacino, Jaclyn M. Goodrich, Dana C. Dolinoy, Laurie K. Svoboda
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Genomic imprinting, a phenomenon by which genes are expressed in a monoallelic, parent-of-origin-dependent fashion, is critical for normal brain development. Expression of imprinted genes is regulated via epigenetic mechanisms, including DNA methylat
Externí odkaz:
https://doaj.org/article/28086dec763f403ca18c0ada5952ac23
Autor:
Elizabeth R. Lawlor, Costas A. Lyssiotis, Jolanta Grembecka, Tomasz Cierpicki, Dong Chen, Trupta Purohit, Joshua Bradin, Zeribe C. Nwosu, Elena Haarer, Alessandra X. Garcia, Ramon Ocadiz Ruiz, Abhijay Kumar, Laurie K. Svoboda, Allegra G. Hawkins, April A. Apfelbaum, Jennifer A. Jiménez
Supplementary Figure S1. Real-time cell proliferation analysis of shATF4, MI-503 treatment, and dox-inducible shMEN1 knockdown in Ewing sarcoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65896b8b3795e1db6d930758a68a4535
https://doi.org/10.1158/1541-7786.22526076
https://doi.org/10.1158/1541-7786.22526076
Autor:
Elizabeth R. Lawlor, Costas A. Lyssiotis, Jolanta Grembecka, Tomasz Cierpicki, Dong Chen, Trupta Purohit, Joshua Bradin, Zeribe C. Nwosu, Elena Haarer, Alessandra X. Garcia, Ramon Ocadiz Ruiz, Abhijay Kumar, Laurie K. Svoboda, Allegra G. Hawkins, April A. Apfelbaum, Jennifer A. Jiménez
shRNA sequences, plasmid information, western blot antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139626eab5c5eba6e20a18d4a1d85c80
https://doi.org/10.1158/1541-7786.22526064
https://doi.org/10.1158/1541-7786.22526064