Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Laurie Jackson-Grusby"'
Autor:
Sung Jin Huh, Kendell Clement, David Jee, Alessandra Merlini, Sibgat Choudhury, Reo Maruyama, Ronnie Yoo, Anna Chytil, Patrick Boyle, Fei Ann Ran, Harold L. Moses, Mary Helen Barcellos-Hoff, Laurie Jackson-Grusby, Alexander Meissner, Kornelia Polyak
Publikováno v:
Stem Cell Reports, Vol 4, Iss 2, Pp 297-311 (2015)
Postnatal mammary gland development and differentiation occur during puberty and pregnancy. To explore the role of DNA methylation in these processes, we determined the genome-wide DNA methylation and gene expression profiles of CD24+CD61+CD29hi, CD2
Externí odkaz:
https://doaj.org/article/e4fb6000f9f5445093db53612eb10e4a
Publikováno v:
genesis. 52:39-48
Summary RNA interference (RNAi) is a powerful approach to phenocopy mutations in many organisms. Gold standard conventional knock-out mouse technology is labor- and time-intensive; however, off-target effects may confound transgenic RNAi approaches.
Autor:
Chieyu Lin, Laurie Jackson-Grusby, Azad Bonni, Sidharth V. Puram, Arezu Jahani-Asl, Genevieve Konopka, Caleb M. Yeung, Nuria de la Iglesia
Publikováno v:
Journal of Neuroscience. 32:7806-7818
Malignant gliomas, including glioblastoma multiforme, constitute the most common and aggressive primary brain tumors in adults. The transcription factor signal transducer and activator of transcription 3 (STAT3) plays an essential role in glioblastom
Autor:
Sarah C. R. Elgin, Laurie Jackson-Grusby, Toshikazu Ushijima, James G. Herman, Peter W. Laird, Jasper Rine, Rebecca W. Doerge, Vincenzo Pirrotta, C. David Allis, Thomas Jenuwein, Peter A. Jones, Jingde Zhu, Benjamin Tycko, John D. Carpten, Stephan Beck, Randy L. Jirtle, Bing Lim, Thomas R. Gingeras, Trevor K. Archer, Stephen B. Baylin, Kornelia Polyak, Bradley E. Bernstein, Joseph F. Costello, Andrew P. Feinberg, Carl Wu, Susan J. Clark, Young Joon Kim, Thea D. Tlsty, Shelley L. Berger, Manel Esteller, Henk Stunnenberg, John M. Greally, Robert A. Martienssen, Steven Henikoff
Publikováno v:
Nature, 454, 7205, pp. 711-715
Nature, 454, 711-715
Nature, 454, 711-715
A plan to ‘genomicize’ epigenomics research and pave the way for breakthroughs in the prevention, diagnosis and treatment of human disease.
Autor:
Yasuhiro Yamada, Konstantinos Meletis, Alexander Meissner, Suzanne Nguyen, Haijiang Lin, Laurie Jackson-Grusby, Heinz G. Linhart, Rudolf Jaenisch, Grace C. Lo
Publikováno v:
Molecular and Cellular Biology. 26:2976-2983
Aberrant gene silencing accompanied by DNA methylation is associated with neoplastic progression in many tumors that also show global loss of DNA methylation. Using conditional inactivation of de novo methyltransferase Dnmt3b in Apc(Min/+) mice, we d
Autor:
Yasuhiro Yamada, Tobias Brambrink, William M. Rideout, Teresa M. Holm, Rudolf Jaenisch, Laurie Jackson-Grusby
Publikováno v:
Cancer Cell. 8(4):275-285
SummaryLoss of imprinting (LOI), commonly observed in human tumors, refers to loss of monoallelic gene regulation normally conferred by parent-of-origin-specific DNA methylation. To test the function of LOI in tumorigenesis, we developed a model by u
Autor:
Stephanie B. Jacobs, Yinghong Ma, Laurie Jackson-Grusby, José A. Torres-Betancourt, Mary-Ann Mastrangelo, Theodore P. Rasmussen, Rudolf Jaenisch
Publikováno v:
Journal of Cell Science. 118:1607-1616
In mammalian heterochromatin, cytosine bases of CpG dinucleotides are symmetrically modified by methylation. Patterns of CpG methylation are maintained by the action of Dnmt1, the mammalian maintenance cytosine methyltransferase enzyme. We geneticall
Autor:
Jessica Dausman, Joe W. Gray, Rudolf Jaenisch, François Gaudet, J. Graeme Hodgson, Laurie Jackson-Grusby, Amir Eden, Heinrich Leonhardt
Publikováno v:
Science. 300:489-492
Genome-wide DNA hypomethylation occurs in many human cancers, but whether this epigenetic change is a cause or consequence of tumorigenesis has been unclear. To explore this phenomenon, we generated mice carrying a hypomorphic DNA methyltransferase 1
Autor:
Caroline Samuel, Isabell Jentsch, Anja Rode, Michael R. Speicher, Kevin Eggan, Branko Zevnik, Janet M. Loring, Jennifer A. Erwin, Hartmut Tintrup, Rudolf Jaenisch, Thomas Hennek, Laurie Jackson-Grusby, Ralf Kuehn
Publikováno v:
Nature Biotechnology. 20:455-459
We have devised a general strategy for producing female mice from 39,X0 embryonic stem (ES) cells derived from male cell lines carrying a targeted mutation of interest. We show that the Y chromosome is lost in 2% of subclones from 40,XY ES cell lines
Autor:
Kendell Clement, Kornelia Polyak, Patrick J Boyle, Sung Jin Huh, Ronnie Yoo, Anna Chytil, David Jee, Alessandra Merlini, Alexander Meissner, Fei Ann Ran, Harold L. Moses, Reo Maruyama, Mary Helen Barcellos-Hoff, Laurie Jackson-Grusby, Sibgat Choudhury
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 4, Iss 2, Pp 297-311 (2015)
Stem cell reports, vol 4, iss 2
Stem Cell Reports, Vol 4, Iss 2, Pp 297-311 (2015)
Stem cell reports, vol 4, iss 2
Summary Postnatal mammary gland development and differentiation occur during puberty and pregnancy. To explore the role of DNA methylation in these processes, we determined the genome-wide DNA methylation and gene expression profiles of CD24+CD61+CD2