Identification of a Novel NRG1 Fusion with Targeted Therapeutic Implications in Locally Advanced Pediatric Cholangiocarcinoma: A Case Report

Autor: Sarah G. Mitchell, Gargi D. Basu, Bree Eaton, Laurie J. Goodman, Kelly C. Goldsmith

Publikováno v: Case Reports in Oncology, Vol 16, Iss 1, Pp 249-255 (2023)

Locally advanced cholangiocarcinoma has a poor prognosis, with long-term survival only for patients where complete surgical resection is achieved. Median overall survival with chemotherapy alone is less than 1 year. Novel strategies combining convent

Externí odkaz: https://doaj.org/article/7d4d20c363054d2fb1a8935b330229af

Analytic validation and clinical utilization of the comprehensive genomic profiling test, GEM ExTra

Autor: Audrey A. Ozols, Tracey White, Gargi D. Basu, Laurie J. Goodman, Janine LoBello, Amy King, Stephen D. Mastrian, Cody Babb, Matthew Halbert, Ryan Richholt, Jessica Aldrich, Nathan Garinger, Szabolcs Szelinger, Thomas Royce

Publikováno v: Oncotarget

We developed and analytically validated a comprehensive genomic profiling (CGP) assay, GEM ExTra, for patients with advanced solid tumors that uses Next Generation Sequencing (NGS) to characterize whole exomes employing a paired tumor-normal subtract

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ad878725354129e5699b030258c99d
https://pubmed.ncbi.nlm.nih.gov/33889297

Genomic profiling of gastrointestinal cancers by comprehensive tumor-normal sequencing

Autor: Audrey A. Ozols, Szabolcs Szelinger, Thanemozhi G. Natarajan, Janine LoBello, Pawan Noel, Laurie J. Goodman, Susan M. Dombrowski, Fadel S. Alyaqoub, Gargi D. Basu, Thomas Royce

Publikováno v: Journal of Clinical Oncology. 39:109-109

109 Background: Gastrointestinal cancers (GIC) account for 26% of global cancer incidence and 35% of cancer-related deaths. We investigated the molecular landscape and therapeutic targets across 18 types of GIC using whole exome (WES) and whole trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76b6da12876ff816e38a09bbcaee003e
https://doi.org/10.1200/jco.2021.39.3_suppl.109

Providing CLARITY: 3D Imaging of Biomarkers in Tumor Samples

Autor: Qi Shen, Laurie J. Goodman, Yesim Gökmen-Polar, Sunil Badve, Yi Chen

Publikováno v: Biophotonics Congress: Biomedical Optics Congress 2018 (Microscopy/Translational/Brain/OTS).

The CLARITY method was used to transform core needle biopsies from patients with breast cancer, into optically transparent tissues, followed by multiplexed immunostaining and 3D imaging of key biomarkers. This data was compared to conventional FFPE t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcfc07893839265f7d64605860aa8d3c
https://doi.org/10.1364/microscopy.2018.mf3a.1

Characterization of a multicomponent receptor for GDNF

Autor: Mark W. Moore, Donna M. Stone, Mark Armanini, Franz Hefti, James J.S. Treanor, Alun M. Davies, Richard A. Pollock, Laurie J. Goodman, Christopher E. Henderson, Masahide Takahashi, Arnon Rosenthal, Kristian Todd Poulsen, Naoya Asai, Christa L. Gray, Heidi S. Phillips, Richard Vandlen, Frederic J. de Sauvage, Audry Goddard, Claus D. Beck, Anna Buj-Bello

Publikováno v: ResearcherID
Nature
Nature, 1996, 382 (6586), pp.80-83. ⟨10.1038/382080A0⟩
Nature, Nature Publishing Group, 1996, 382 (6586), pp.80-83. ⟨10.1038/382080A0⟩

Glial-cell-line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Despite the potential clinical and physiological import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745d1fe43a8b68bb148dadfdd2922e6f
https://doi.org/10.1038/382080a0