Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Laurie H Sanders"'
Autor:
Yuan Yuan, Huizhong Li, Kashyap Sreeram, Tuyana Malankhanova, Ravindra Boddu, Samuel Strader, Allison Chang, Nicole Bryant, Talene A. Yacoubian, David G. Standaert, Madalynn Erb, Darren J. Moore, Laurie H. Sanders, Michael W. Lutz, Dmitry Velmeshev, Andrew B. West
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-23 (2024)
Abstract Background LRRK2-targeting therapeutics that inhibit LRRK2 kinase activity have advanced to clinical trials in idiopathic Parkinson’s disease (iPD). LRRK2 phosphorylates Rab10 on endolysosomes in phagocytic cells to promote some types of i
Externí odkaz:
https://doaj.org/article/cbe5ed539df9444082143ccaca2754bf
Autor:
Nicholas Pena, Tara Richbourg, Claudia P. Gonzalez-Hunt, Rui Qi, Paul Wren, Carrolee Barlow, Natalie F. Shanks, Holly J. Carlisle, Laurie H. Sanders
Publikováno v:
npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Pathogenic mutations in LRRK2 cause Parkinson’s disease (PD). The G2019S variant is the most common, which results in abnormally high kinase activity. Compounds that target LRRK2 kinase activity are currently being developed and tested in
Externí odkaz:
https://doaj.org/article/04c86851f418476ba1a0c1df027d9486
Autor:
Danuta Sastre, Faria Zafar, C. Alejandra Morato Torres, Desiree Piper, Deniz Kirik, Laurie H. Sanders, L. Stanley Qi, Birgitt Schüle
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or
Externí odkaz:
https://doaj.org/article/6d2236de09b34a8e9d0b88bb3b49760a
Publikováno v:
Neurobiology of Disease, Vol 109, Iss , Pp 249-257 (2018)
Parkinson's disease (PD) is a complex, chronic and progressive neurodegenerative disease. While the etiology of PD is likely multifactorial, the protein α-synuclein is a central component to the pathogenesis of the disease. However, the mechanism by
Externí odkaz:
https://doaj.org/article/89ba259b33904393af8a7fdba328e0aa
Autor:
Danuta Sastre, Faria Zafar, C. Alejandra Morato Torres, Desiree Piper, Deniz Kirik, Laurie H. Sanders, Stanley Qi, Birgitt Schüle
Publikováno v:
bioRxiv
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, but no disease modifying therapies have been successful in clinical translation presenting a major unmet medical need. A promising target is alpha-synuclein or its aggre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6037f877f518eb5bd4e743384a14e394
https://doi.org/10.1101/2023.01.24.525105
https://doi.org/10.1101/2023.01.24.525105
Autor:
Nicholas Pena, Claudia P. Gonzalez-Hunt, Rui Qi, Carrolee Barlow, Natalie F. Shanks, Holly J. Carlisle, Laurie H. Sanders
Pathogenic mutations inLRRK2cause Parkinson’s disease (PD). The G2019S variant is the most common, which results in abnormally high kinase activity. Compounds that target LRRK2 kinase activity are currently being developed and tested in clinical tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef34efb569ccbffc275d271bc1d31bc5
https://doi.org/10.1101/2022.11.30.517979
https://doi.org/10.1101/2022.11.30.517979
Autor:
Laurie H. Sanders, Jennifer McCoy, Xiaoping Hu, Pier G. Mastroberardino, Bryan C. Dickinson, Christopher J. Chang, Charleen T. Chu, Bennett Van Houten, J.T. Greenamyre
Publikováno v:
Neurobiology of Disease, Vol 70, Iss , Pp 214-223 (2014)
DNA damage can cause (and result from) oxidative stress and mitochondrial impairment, both of which are implicated in the pathogenesis of Parkinson's disease (PD). We therefore examined the role of mitochondrial DNA (mtDNA) damage in human postmortem
Externí odkaz:
https://doaj.org/article/a3e0fb76bd764bb882e1a79cace17569
Autor:
Laurie H. Sanders, Josée Laganière, Oliver Cooper, Sally K. Mak, B. Joseph Vu, Y. Anne Huang, David E. Paschon, Malini Vangipuram, Ramya Sundararajan, Fyodor D. Urnov, J. William Langston, Philip D. Gregory, H. Steve Zhang, J. Timothy Greenamyre, Ole Isacson, Birgitt Schüle
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 381-386 (2014)
Parkinson's disease associated mutations in leucine rich repeat kinase 2 (LRRK2) impair mitochondrial function and increase the vulnerability of induced pluripotent stem cell (iPSC)-derived neural cells from patients to oxidative stress. Since mitoch
Externí odkaz:
https://doaj.org/article/d505d3408a924944819f08f5874cf168
Autor:
Kristin M. Miner, Tarun N. Bhatia, Anuj S. Jamenis, Rachel N. Clark, Nevil Abraham, Dhivyaa Rajasundaram, Sylvie Sauvaigo, R. A. Stetler, Jun Chen, Laurie H. Sanders, Kelvin C. Luk, Rehana K. Leak
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96c126e9832bfd61425d1f3a2a9f08c2
https://doi.org/10.1096/fasebj.2022.36.s1.r3221
https://doi.org/10.1096/fasebj.2022.36.s1.r3221
Autor:
Bankanidhi Sahoo, Irene Arduini, Kenneth W Drombosky, Ravindra Kodali, Laurie H Sanders, J Timothy Greenamyre, Ronald Wetzel
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0155747 (2016)
Expansion of the polyglutamine (polyQ) track of the Huntingtin (HTT) protein above 36 is associated with a sharply enhanced risk of Huntington's disease (HD). Although there is general agreement that HTT toxicity resides primarily in N-terminal fragm
Externí odkaz:
https://doaj.org/article/0d7d5852f7b5410c952937e6b1b377c6