Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Laurie Gayte"'
Autor:
Gabrielle Manteaux, Alix Amsel, Blanche Riquier-Morcant, Jaime Prieto Romero, Laurie Gayte, Benjamin Fourneaux, Marion Larroque, Nadège Gruel, Chloé Quignot, Gaelle Perot, Solenn Jacq, Madi Y. Cisse, Pascal Pomiès, Coralie Sengenes, Frédéric Chibon, Maud Heuillet, Floriant Bellvert, Sarah Watson, Sebastien Carrere, Nelly Firmin, Romain Riscal, Laetitia K. Linares
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Dedifferentiated and Well-differentiated liposarcoma are characterized by a systematic amplification of the Murine Double Minute 2 (MDM2) oncogene. We demonstrate that p53-independent metabolic functions of chromatin-bound MDM2 are exacerbat
Externí odkaz:
https://doaj.org/article/b0fec26a6a6443049f7aba6728e01c6f
Autor:
Nadège Gruel, Chloé Quignot, Laëtitia Lesage, Sophie El Zein, Sylvie Bonvalot, Dimitri Tzanis, Khadija Ait Rais, Fabien Quinquis, Bastien Manciot, Julien Vibert, Nadine El Tannir, Ahmed Dahmani, Héloïse Derrien, Didier Decaudin, Ivan Bièche, Laura Courtois, Odette Mariani, Laëtitia K. Linares, Laurie Gayte, Sylvain Baulande, Joshua J. Waterfall, Olivier Delattre, Gaëlle Pierron, Sarah Watson
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Dedifferentiated liposarcoma (DDLPS) is the most frequent high-grade soft tissue sarcoma subtype. It is characterized by a component of undifferentiated tumor cells coexisting with a component of well-differentiated adipocytic tumor cells. B
Externí odkaz:
https://doaj.org/article/9071f50c747241d985e7d638e844b164
Autor:
Matthieu Lacroix, Laetitia K. Linares, Natalia Rueda-Rincon, Katarzyna Bloch, Michela Di Michele, Carlo De Blasio, Caroline Fau, Laurie Gayte, Emilie Blanchet, Aline Mairal, Rita Derua, Fernando Cardona, Diane Beuzelin, Jean-Sebastien Annicotte, Nelly Pirot, Adeline Torro, Francisco J. Tinahones, Florence Bernex, Justine Bertrand-Michel, Dominique Langin, Lluis Fajas, Johannes V. Swinnen, Laurent Le Cam
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The p53 tumor suppressor is also a regulator of metabolism, but the mechanisms controlling p53-associated metabolic activities remain poorly understood. Here the authors report that the deletion of the multifunctional protein E4F1 is protective again
Externí odkaz:
https://doaj.org/article/00ec515c8ba444a682cea51127843aeb
Autor:
Marie-Christine Chateau, Laurent Le Cam, Giuseppe Arena, Nelly Firmin, Jean-Charles Portais, Madi Y. Cissé, Laurie Gayte, Aurélie Maran-Gonzalez, Laetitia K. Linares, Hélène Delpech, Frédéric Chibon, Romain Riscal, Floriant Bellvert, Maryse Fuentes, Sophie Le Gellec, Charles Theillet, Maud Heuillet, Samuel Pyrdziak, S. Carrere
Publikováno v:
Science Translational Medicine
Science Translational Medicine, 2020, 12 (547), ⟨10.1126/scitranslmed.aay2163⟩
Science Translational Medicine, American Association for the Advancement of Science, 2020, 12 (547), ⟨10.1126/scitranslmed.aay2163⟩
Science Translational Medicine, 2020, 12 (547), ⟨10.1126/scitranslmed.aay2163⟩
Science Translational Medicine, American Association for the Advancement of Science, 2020, 12 (547), ⟨10.1126/scitranslmed.aay2163⟩
International audience; Well-differentiated and dedifferentiated liposarcomas (LPSs) are characterized by a systematic amplification of the MDM2 oncogene, which encodes a key negative regulator of the p53 pathway. The molecular mechanisms underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00954e05cd789186170d9dc82fef6c71
https://hal.inrae.fr/hal-03436075
https://hal.inrae.fr/hal-03436075
Autor:
Kevin Nay, Romain Riscal, Christelle Bertrand-Gaday, Craig E. Cameron, Christelle Koechlin-Ramonatxo, Madi Y. Cissé, Laurent Le Cam, Béatrice Chabi, Béatrice Orsetti, Laetitia K. Linares, Kerren Murray, Charles Vincent, Hervé Dubouchaud, Laurie Gayte, Markus Kastner, Samuel Pyrdziak, Florence Bernex, Giuseppe Arena, Miria Ricchetti, François Casas, Laurent Chatre, Claire Angebault-Prouteau, Maryse Fuentes, Sandrine Etienne-Manneville, Anne Lombès, Jamie J. Arnold, Jean-Christophe Marine
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2018, 69 (4), pp.594-609. ⟨10.1016/j.molcel.2018.01.023⟩
Mol Cell
Molecular Cell, 2018, 69 (4), pp.594-609. ⟨10.1016/j.molcel.2018.01.023⟩
Molecular Cell, Elsevier, 2018, 69 (4), pp.594-609.e8. ⟨10.1016/j.molcel.2018.01.023⟩
Molecular Cell, Elsevier, 2018, 69 (4), pp.594-609. ⟨10.1016/j.molcel.2018.01.023⟩
Mol Cell
Molecular Cell, 2018, 69 (4), pp.594-609. ⟨10.1016/j.molcel.2018.01.023⟩
Molecular Cell, Elsevier, 2018, 69 (4), pp.594-609.e8. ⟨10.1016/j.molcel.2018.01.023⟩
International audience; Accumulating evidence indicates that the MDM2 oncoprotein promotes tumorigenesis beyond its canonical negative effects on the p53 tumor suppressor, but these p53-independent functions remain poorly understood. Here, we show th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be7a0e2ae66629fcfd1cc717085097d0
https://hal.archives-ouvertes.fr/hal-01837662
https://hal.archives-ouvertes.fr/hal-01837662
Autor:
Héléna Boutzen, Clément Larrue, Pierre Millard, Laurent Fernando, Laurent Le Cam, Laurie Gayte, Noémie Gadaud, Tony Kaoma, Pierre-Luc Mouchel, Evgenia Turtoi, Jean-Charles Portais, Nesrine Aroua, Justine Bertrand-Michel, Courtney Dinardo, Tony Lionel Palama, Yves Collette, Camille Montersino, Laure Tonini, Yves Gibon, Madi Y. Cissé, Cédric Cassan, Koichi Takahashi, Florence Castelli, Pierre Bories, Audrey Bidet, Joe Marszalek, Martin Carroll, Guillaume Cazals, Claire Calmettes, Arnaud Pigneux, Thomas Farge, Lucille Stuani, Feng Wang, Fabien Jourdan, Laetitia K. Linares, Mary A. Selak, Lara Gales, Andrew M. Futreal, Mathilde Gotanègre, Maud Heuillet, Kiyomi Morita, Jean-Emmanuel Sarry, Andrei Turtoi, Nicolas Broin, Christian Recher, Marina Konopleva, Mohsen Hosseini, Christophe Junot, Claudie Bosc, Emeline Chu-Van, Marine Fraisse, Nathalie Saint-Laurent, Lindsay Peyriga, Rémy Castellano, Estelle Saland, Natalia Baran, Norbert Vey, Frédéric Lopez, Floriant Bellvert, Marie Sabatier, Nathalie Poupin
Publikováno v:
SSRN Electronic Journal.
Isocitrate dehydrogenases (IDH) are involved in redox control and central metabolism. We hypothesized that key metabolic fluxes are selectively reprogrammed to maintain biosynthetic homeostasis and lower drug responses in IDH mutant acute myeloid leu
Autor:
Matthieu Lacroix, Laurence Pessemesse, Geneviève Rodier, Maud Heuillet, Hélène Delpech, Audrey Boutron, Charlene Berthet, François Casas, Florence Bernex, Berfin Seyran, Olivier Kirsh, Michèle Brivet, Jean-Charles Portais, Laurent Le Cam, Claude Sardet, Thibault Houlès, Laurie Gayte, Floriant Bellvert
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (39), pp.10998-11003. ⟨10.1073/pnas.1602754113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (39), pp.10998-11003. ⟨10.1073/pnas.1602754113⟩
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2016, 113 (39), pp.10998-11003. ⟨10.1073/pnas.1602754113⟩
Proceedings of the National Academy of Sciences of the United States of America, 2016, 113 (39), pp.10998-11003. ⟨10.1073/pnas.1602754113⟩
The mitochondrial pyruvate dehydrogenase (PDH) complex (PDC) acts as a central metabolic node that mediates pyruvate oxidation and fuels the tricarboxylic acid cycle to meet energy demand. Here, we reveal another level of regulation of the pyruvate o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630318d91d52479a752fe4e2403150e9
https://hal.archives-ouvertes.fr/hal-01837650
https://hal.archives-ouvertes.fr/hal-01837650