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Autor:
Laurie G. Castonguay, Sookhee Ha, Lex H.T. Van der Ploeg, Chun-Pyn Shen, Ihor E. Kopka, Zhege J. Lao, Mark T. Goulet, Linus S. Lin, William K. Hagmann, Tung M. Fong, James P. Jewell, Thomas J. Lanza
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4757-4761
The design, synthesis, and binding activity of ring constrained analogs of the acyclic cannabinoid-1 receptor (CB1R) inverse agonist taranabant 1 are described. The initial inspiration for these taranabant derivatives was its conformation 1a, determi