Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Laurie E Kilpatrick"'
Autor:
Jordan C Langston, Michael T Rossi, Qingliang Yang, William Ohley, Edwin Perez, Laurie E Kilpatrick, Balabhaskar Prabhakarpandian, Mohammad F Kiani
Publikováno v:
Vascular Biology, Vol 4, Iss 1, Pp R15-R34 (2022)
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in inc
Externí odkaz:
https://doaj.org/article/95cdab2dcca64d429a1149bc75f259c8
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195379 (2018)
Sepsis is characterized by an intense systemic inflammatory response activating a cascade of proinflammatory events resulting in leukocyte dysregulation and host tissue damage. The lung is particularly susceptible to systemic inflammation, leading to
Externí odkaz:
https://doaj.org/article/fc9efd8e9e0043b784230d3bf81524b3
Autor:
Qingliang Yang, Jordan C. Langston, Roman Prosniak, Samantha Pettigrew, Huaqing Zhao, Edwin Perez, Hannah Edelmann, Nadia Mansoor, Carmen Merali, Salim Merali, Nathaniel Marchetti, Balabhaskar Prabhakarpandian, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
PurposeSepsis is a clinical syndrome defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis is a highly heterogeneous syndrome with distinct phenotypes that impact immune function and response to inf
Externí odkaz:
https://doaj.org/article/4a549513b5354850bcc150fe7987e872
Autor:
Dan Liu, Jordan C. Langston, Balabhaskar Prabhakarpandian, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2024)
Sepsis is a global health concern accounting for more than 1 in 5 deaths worldwide. Sepsis is now defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Sepsis can develop from bacterial (gram negative or g
Externí odkaz:
https://doaj.org/article/2075bf0ecf0a44f586a6623f3f920686
Autor:
Emmanuel Boadi Amoafo, Philomena Entsie, Samara Albayati, Glenn P. Dorsam, Satya P. Kunapuli, Laurie E. Kilpatrick, Elisabetta Liverani
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Sepsis, a complex clinical syndrome resulting from a serious infection, is a major healthcare problem associated with high mortality. Sex-related differences in the immune response to sepsis have been proposed but the mechanism is still unknown. Puri
Externí odkaz:
https://doaj.org/article/4289becbc13c498f878d92b452f3030e
Publikováno v:
Shock. 59:224-231
Sepsis is a major health issue and a leading cause of death in hospitals globally. The treatment of sepsis is largely supportive and there are no therapeutics available that target the underlying pathophysiology of the disease. The development of the
Autor:
Qingliang Yang, Harshani Wijerathne, Jordan C. Langston, Mohammad F. Kiani, Laurie E. Kilpatrick
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 7770 (2021)
The endothelium is the inner layer of all blood vessels and it regulates hemostasis. It also plays an active role in the regulation of the systemic inflammatory response. Systemic inflammatory disease often results in alterations in vascular endothel
Externí odkaz:
https://doaj.org/article/c34f57b236214d4ba7a530a9d97e4d56
Publikováno v:
Diabetes. 71(10)
Several unrelated findings led us to hypothesize that induction of autoimmunity is a consequence of a prior major inflammatory event in individuals with susceptible HLA phenotypes and elevated sensitivity to cytokines and free fatty acids (FFA). We o
Publikováno v:
Shock
Sepsis is a life-threatening syndrome of organ dysfunction caused by a dysregulated host response to infection characterized by excessive neutrophil infiltration into vital organs. In sepsis, patients often die of organ failure and therapies directed
Autor:
Mohammad F. Kiani, Laurie E. Kilpatrick, Balabhaskar Prabhakarpandian, Yuan Tang, Jordan C. Langston, Qingliang Yang
Publikováno v:
Journal of Visualized Experiments.
Leukocyte-endothelial cell interactions play an important role in inflammatory diseases such as sepsis. During inflammation, excessive migration of activated leukocytes across the vascular endothelium into key organs can lead to organ failure. A phys