Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Laurie D. Cohen"'
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Synaptic integrity and function depend on myriad proteins - labile molecules with finite lifetimes that need to be continually replaced with freshly synthesized copies. Here we describe experiments designed to expose synaptic (and neuronal) propertie
Externí odkaz:
https://doaj.org/article/33c25df387dc4b65a99d3d4d913e1da8
Publikováno v:
F1000Research, Vol 9 (2020)
Background: HaloTag is a modified bacterial enzyme that binds rapidly and irreversibly to an array of synthetic ligands, including chemical dyes. When expressed in live cells in conjunction with a protein of interest, HaloTag can be used to study pro
Externí odkaz:
https://doaj.org/article/c235e36411e1494f993398a1f340475a
Publikováno v:
F1000Research, Vol 9 (2020)
Background: HaloTag is a modified bacterial enzyme that binds rapidly and irreversibly to an array of synthetic ligands, including chemical dyes. When expressed in live cells in conjunction with a protein of interest, HaloTag can be used to study pro
Externí odkaz:
https://doaj.org/article/ce9a656c54d44252b66ae7cc9e8359e3
Autor:
Laurie D. Cohen, Noam E. Ziv
Publikováno v:
F1000Research, Vol 6 (2017)
Maintaining synaptic integrity and function depends on the continuous removal and degradation of aged or damaged proteins. Synaptic protein degradation has received considerable attention in the context of synaptic plasticity and growing interest in
Externí odkaz:
https://doaj.org/article/f48b19b5f36141108f1d163bacdba922
Autor:
Noam E. Ziv, Laurie D Cohen
Publikováno v:
Current Opinion in Neurobiology. 57:9-16
Neuronal proteostasis is uniquely challenged by the extraordinary architecture of neurons, the vast number of synapses they form, and the need to precisely preserve function at individual synapses. Quantitative information on protein lifetimes can pr
Publikováno v:
F1000Research
Background: HaloTag is a modified bacterial enzyme that binds rapidly and irreversibly to an array of synthetic ligands, including chemical dyes. When expressed in live cells in conjunction with a protein of interest, HaloTag can be used to study pro
Publikováno v:
The EMBO Journal
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis, little is known on the routes by which synaptic proteins are degraded. Here we systematica
Autor:
Noam E. Ziv, Laurie D Cohen
Publikováno v:
F1000Research
Maintaining synaptic integrity and function depends on the continuous removal and degradation of aged or damaged proteins. Synaptic protein degradation has received considerable attention in the context of synaptic plasticity and growing interest in
Autor:
Laurie D Cohen, Daniela C. Dieterich, Anke Müller, J. Douglas Armstrong, Noam E. Ziv, Oksana Sorokina, Tamar Ziv, Rina Zuchman
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e63191 (2013)
PLoS ONE; Vol 8
Cohen, L D, Zuchman, R, Sorokina, O, Müller, A, Dieterich, D C, Armstrong, J D, Ziv, T, Ziv, N E & Akaaboune, M (ed.) 2013, ' Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance ', PLoS ONE, vol. 8, no. 5, e63191 . https://doi.org/10.1371/journal.pone.0063191
PLoS ONE
PLoS ONE; Vol 8
Cohen, L D, Zuchman, R, Sorokina, O, Müller, A, Dieterich, D C, Armstrong, J D, Ziv, T, Ziv, N E & Akaaboune, M (ed.) 2013, ' Metabolic Turnover of Synaptic Proteins: Kinetics, Interdependencies and Implications for Synaptic Maintenance ', PLoS ONE, vol. 8, no. 5, e63191 . https://doi.org/10.1371/journal.pone.0063191
PLoS ONE
Chemical synapses contain multitudes of proteins, which in common with all proteins, have finite lifetimes and therefore need to be continuously replaced. Given the huge numbers of synaptic connections typical neurons form, the demand to maintain the
Autor:
Francesca Vitali, Laurie D Cohen, Andrea Demartini, Angela Amato, Vincenzo Eterno, Alberto Zambelli, Riccardo Bellazzi
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170363 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0162407.].
Externí odkaz:
https://doaj.org/article/3c4661ea27d74bbfa1fe49cc492bdbc7