Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Laurie C. Haws"'
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
HFPO-DA (ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate; CASRN 62037-80-3) is a component of the GenX technology platform used as a polymerization aid in the manufacture of some types of fluoropolymers. The liver is the primary target
Externí odkaz:
https://doaj.org/article/d689d5df4c3846ae9e1640cd9bf92500
Publikováno v:
Toxicological Sciences. 192:15-29
HFPO-DA (ammonium, 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoate) is a short-chain polyfluorinated alkyl substance (PFAS) used in the manufacture of some types of fluorinated polymers. Like many PFAS, toxicity studies with HFPO-DA indicate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f9607b33433b019341e35e8e516c2273
https://doi.org/10.1093/toxsci/kfad004
https://doi.org/10.1093/toxsci/kfad004
Publikováno v:
Birth Defects Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4aae054ab7c98101ffdd75db2eba872
https://doi.org/10.1002/bdr2.2185
https://doi.org/10.1002/bdr2.2185
Autor:
Chad M. Thompson, Melissa M. Heintz, Jeffrey C. Wolf, Roza Cheru, Laurie C. Haws, John M. Cullen
Publikováno v:
Toxicologic Pathology. :019262332311590
Ammonium 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)-propanoate (HFPO-DA) is a short chain member of per- and polyfluoroalkyl substances (PFAS). To better understand the relevance of histopathological effects seen in livers of mice exposed to HFPO-DA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0e5302416125299c8332ccb27975a8
https://doi.org/10.1177/01926233231159078
https://doi.org/10.1177/01926233231159078
Autor:
Anne H. Chappelle, Kimberly W. White, Donna L. Mendrick, Linda S. Birnbaum, Laurie C. Haws, Suzanne Fitzpatrick, K. Nadira De Abrew, Katerine S. Saili, Jill A Franzosa, Thomas B. Knudsen, Susan Y. Euling, Alison Elder, George P. Daston, Nicole Kleinstreuer, Alexandra Turley, Ruthann A. Rudel, Dana C. Dolinoy, Elaine M. Faustman, Germaine M. Buck Louis, Thaddeus T. Schug, Todd J. Zurlinden, Robyn L Tanguay, Barbara A. Wetmore, Derik E. Haggard, Kristi Pullen Fedinick
Publikováno v:
Toxicol Sci
FutureTox IV, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2018. Building upon FutureTox I, II, and III, this conference focused on the latest science and technology for in vitro profiling and in silico m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::310085fc00705890b8369a9c0dbe4576
https://doi.org/10.1093/toxsci/kfab013
https://doi.org/10.1093/toxsci/kfab013
Publikováno v:
Current Research in Toxicology, Vol 2, Iss, Pp 30-41 (2021)
Current Research in Toxicology
Current Research in Toxicology
Graphical abstract
Highlights • Minimal global gene expression changes at concentrations below 600 ppm of 1,4-dioxane. • Increased phase II metabolism genes and cellular cycle signaling at >600 ppm. • Increased cell cycle signaling occurre
Highlights • Minimal global gene expression changes at concentrations below 600 ppm of 1,4-dioxane. • Increased phase II metabolism genes and cellular cycle signaling at >600 ppm. • Increased cell cycle signaling occurre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc2461f060a5b56d990e73c4159752dd
https://doi.org/10.1016/j.crtox.2021.01.003
https://doi.org/10.1016/j.crtox.2021.01.003
Autor:
Janice K. Britt, Caroline Ring, Daniele Wikoff, Robert A. Budinsky, Jonathan D. Urban, Laurie C. Haws, Seneca Fitch
Publikováno v:
Toxicological Sciences. 179:162-182
Regulatory agencies have derived noncancer toxicity values for 2,3,7,8-tetrachlorodibenzo-p-dioxin based on reduced sperm counts relying on single studies from a large body of evidence. Techniques such as meta-regression allow for greater use of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecbc176ed4cb63d88b92d73df6be243d
https://doi.org/10.1093/toxsci/kfaa171
https://doi.org/10.1093/toxsci/kfaa171
Autor:
James E. Klaunig, Jeffrey C. Wolf, Grace A. Chappell, Laurie C. Haws, John M. Cullen, Chad M. Thompson
Publikováno v:
Toxicologic Pathology
GenX is an alternative to environmentally persistent long-chain perfluoroalkyl and polyfluoroalkyl substances. Mice exposed to GenX exhibit liver hypertrophy, elevated peroxisomal enzyme activity, and other apical endpoints consistent with peroxisome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7765172ff6915640b93d5aa5a683fc0
https://doi.org/10.1177/0192623320905803
https://doi.org/10.1177/0192623320905803
Publikováno v:
Journal of Applied Toxicology
Ammonium 2,3,3,3‐tetrafluoro‐2‐(heptafluoropropoxy)‐propanoate, also known as GenX, is a processing aid used in the manufacture of fluoropolymers. GenX is one of several chemistries developed as an alternative to long‐chain poly‐fluoroalk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::921aab73b14dd7aed1b5b039ab1aeea7
https://doi.org/10.1002/jat.3812
https://doi.org/10.1002/jat.3812
Using total petroleum hydrocarbon (TPH) measurements as a tool for assessing potential human health risks associated with exposures to petroleum products in the environment poses unique challenges, as TPH represents highly variable and complex mixtur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33af4278b10f88b5be5d263819547afe
