Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Laurie B. Owen-Schaub"'
Autor:
Kirankumar Vemula, Liselotte E. Jensen, Srinivas Mummidi, Laurie B. Owen-Schaub, Bysani Chandrasekar, Rama Mohan Surabhi, Min Li-Weber
Publikováno v:
Journal of Biological Chemistry. 279:20221-20233
Endothelial cells are the primary targets of circulating immune and inflammatory mediators. We hypothesize that interleukin-18, a proinflammatory cytokine, induces endothelial cell apoptosis. Human cardiac microvascular endothelial cells (HCMEC) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ece78b4781daa15b84ac9248140ea5
https://doi.org/10.1074/jbc.m313980200
https://doi.org/10.1074/jbc.m313980200
Publikováno v:
Cancer Research. 64:363-369
Present cancer gene therapy using proapoptotic genes has had limited success because the therapy is prone to cause side effects as a result of the lack of tissue and cancer specificity. To target cancer cells without damaging normal cells, we have de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51e2c7d62207afb772da4eef8c62d3e9
https://doi.org/10.1158/0008-5472.can-03-2507
https://doi.org/10.1158/0008-5472.can-03-2507
Publikováno v:
Journal of Biological Chemistry. 278:25428-25434
Proapoptotic gene transfer to promote death or to augment killing by DNA-damaging agents represents a promising strategy for cancer therapy. We have constructed an adenoviral Tet-Off trade mark vector with tightly controlled expression of Bid (Ad-Bid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7a16f35ac98fe181faec974d199f0d
https://doi.org/10.1074/jbc.m302058200
https://doi.org/10.1074/jbc.m302058200
Autor:
A Gorny, Allal Ouhtit, Laurie B. Owen-Schaub, Honnavara N. Ananthaswamy, H. Konrad Muller, Laurie L. Hill
Publikováno v:
The American Journal of Pathology. 157:1975-1981
Skin cells containing excessive ultraviolet (UV) radiation-induced DNA damage are eliminated by apoptosis that involves the p53 pathway and Fas/Fas-Ligand (Fas-L) interactions. To determine whether dysregulation of apoptosis plays a role in skin canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1629726537f5114d502635198ceb3769
https://doi.org/10.1016/s0002-9440(10)64836-5
https://doi.org/10.1016/s0002-9440(10)64836-5
Autor:
Jeffrey K. Actor, Robert L. Hunter, Laurie L. Hill, Darren W. Davis, Virginia E. Watson, Laurie B. Owen-Schaub, Chinnaswamy Jagannath, David J. McConkey
Publikováno v:
The Journal of Pathology. 190:211-220
This study examined mechanisms contributing to pulmonary immunopathology following acute Mycobacterium tuberculosis (MTB) infection in vivo in a murine model. A/J and C57BL/6 mice were intravenously infected with MTB (Erdman). Pathological difference
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::685a0b77cf3b3fd54740819d3c366de2
https://doi.org/10.1002/(sici)1096-9896(200002)190:2<211::aid-path530>3.0.co
https://doi.org/10.1002/(sici)1096-9896(200002)190:2<211::aid-path530>3.0.co
Autor:
Noriaki Tanaka, Yoshihiko Kadowaki, Laurie B. Owen-Schaub, Toshiyoshi Fujiwara, Jack A. Roth, Akio Hizuta, Jianghua Shao, Masahiko Nishizaki, Yoshinori Morimoto, Takuya Fukazawa
Publikováno v:
Oncogene. 18:2189-2199
The CD95 (Fas/APO-1) system regulates a number of physiological and pathological processes of cell death. The ligand for CD95 induces apoptosis in sensitive target cells by interacting with a transmembrane cell surface CD95 receptor. We previously re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1daf5a1ed1b205a66ec6d6139750682d
https://doi.org/10.1038/sj.onc.1202561
https://doi.org/10.1038/sj.onc.1202561
Publikováno v:
Molecular and Cellular Biology. 19:2098-2108
Fas (CD95) and Fas ligand (CD95L) are an interacting receptor-ligand pair required for immune homeostasis. Lymphocyte activation results in the upregulation of Fas expression and the acquisition of sensitivity to FasL-mediated apoptosis. Although Fas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d51bdb248f99a346384549cad9756e5
https://doi.org/10.1128/mcb.19.3.2098
https://doi.org/10.1128/mcb.19.3.2098
Publikováno v:
The Journal of Experimental Medicine
Induction of antigen-specific suppression elicited by environmental insults, such as ultraviolet (UV)-B radiation in sunlight, can inhibit an effective immune response in vivo and may contribute to the outgrowth of UV-induced skin cancer. Although UV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736db8120e4703ad969bd509a525553e
http://europepmc.org/articles/PMC2193030
http://europepmc.org/articles/PMC2193030
Autor:
Laurie B. Owen-Schaub, James R. Jabbur, Katharina Clodi, Wei Zhang, Tohru Kobayashi, John C. Reed, Michael Andreeff, Hiroshi Shiku, Ugo Consoli, Sanbao Ruan
Publikováno v:
Cell Death & Differentiation. 5:584-591
In this study, we examined the effects of radiation and ara-C on induction of apoptosis and on the apoptosis-promoting genes p53, Bax and Fas/APO-1, in BV173 human leukemia cells, which harbor the wild-type p53 gene. It has been reported that p53 upr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e41264ebbdfbc15d21e71cb2a009c91
https://doi.org/10.1038/sj.cdd.4400382
https://doi.org/10.1038/sj.cdd.4400382