Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Laurie A. Boyer"'
Autor:
Shu Hui Neo, Zhisheng Her, Rashidah Othman, Ching Ann Tee, Li Ching Ong, Yuehua Wang, Irwin Tan, Jaylen Tan, Yanmeng Yang, Zheng Yang, Qingfeng Chen, Laurie A. Boyer
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Mesenchymal stromal cells (MSCs) have broad potential as a cell therapy including for the treatment of drug-resistant inflammatory conditions with abnormal T cell proliferation such as graft-versus-host disease (GVHD). Clinical su
Externí odkaz:
https://doaj.org/article/f4d4f8ab1d214fd89f68a7780b2542e0
Autor:
Lauren E. Surface, Paul A. Fields, Vidya Subramanian, Russell Behmer, Namrata Udeshi, Sally E. Peach, Steven A. Carr, Jacob D. Jaffe, Laurie A. Boyer
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1142-1155 (2016)
Summary: Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in embryonic stem cells (ESCs) to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood. Here, we investigat
Externí odkaz:
https://doaj.org/article/4f46d61cfd794302ab5d23e13ef2a9c8
Autor:
Mayuri Rege, Vidya Subramanian, Chenchen Zhu, Tsung-Han S. Hsieh, Assaf Weiner, Nir Friedman, Sandra Clauder-Münster, Lars M. Steinmetz, Oliver J. Rando, Laurie A. Boyer, Craig L. Peterson
Publikováno v:
Cell Reports, Vol 13, Iss 8, Pp 1610-1622 (2015)
The histone variant H2A.Z is a hallmark of nucleosomes flanking promoters of protein-coding genes and is often found in nucleosomes that carry lysine 56-acetylated histone H3 (H3-K56Ac), a mark that promotes replication-independent nucleosome turnove
Externí odkaz:
https://doaj.org/article/41f1b37b887c4f1e803994f1032412ff
Autor:
Smitha Surendran Thamarath, Ching Ann Tee, Shu Hui Neo, Dahou Yang, Rashidah Othman, Laurie A. Boyer, Jongyoon Han
Publikováno v:
Stem Cells Translational Medicine. 12:266-280
SummaryDetection of cellular senescence is important quality analytics for cell therapy products, including mesenchymal stromal cells (MSCs). However, their detection is critically limited by the lack of specific markers and the destructive assays us
Autor:
Vaishnavi V. Phadnis, Emily L. Ricq, Bryan Ferguson, Laurie A. Boyer, John K. Eaton, Yilong Zou, Emily T. Graham, Sateja Paradkar, Stuart L. Schreiber, Pema Maretich, Heather R. Keys, Paul A. Clemons, Whitney S. Henry, Ferenc Reinhardt, Natalie Boehnke, Joshua Fairman, Amy Deik, Vlado Dančík, Robert A. Weinberg, Clary B. Clish, Paula T. Hammond, Wenyu Wang
Publikováno v:
Nature. 585:603-608
Ferroptosis—an iron-dependent, non-apoptotic cell death process—is involved in various degenerative diseases and represents a targetable susceptibility in certain cancers1. The ferroptosis-susceptible cell state can either pre-exist in cells that
Autor:
Pema Maretich, Jacqueline A. Lees, Marguerite Blair, Joon Ho Kang, Hannah R. Hagen, Jette Lengefeld, Chia-Wei Cheng, Adam Antebi, Joachim D. Steiner, Sean J. Morrison, Angelika Amon, Teemu P. Miettinen, Scott R. Manalis, Emily Sullivan, Melanie R. McReynolds, Laurie A. Boyer, Christina Roberts, Ömer H. Yilmaz, Kyra Majors
Publikováno v:
Science Advances
Sci Adv
Sci Adv
Description
Small cell size preserves the function of hematopoietic stem cells (HSCs); HSC enlargement during aging causes their dysfunction.
Stem cells are remarkably small. Whether small size is important for stem cell function is unknown
Small cell size preserves the function of hematopoietic stem cells (HSCs); HSC enlargement during aging causes their dysfunction.
Stem cells are remarkably small. Whether small size is important for stem cell function is unknown
Polycomb Repressive Complex 2 regulates lineage fidelity during embryonic stem cell differentiation.
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110498 (2014)
Polycomb Repressive Complex 2 (PRC2) catalyzes histone H3 lysine 27 tri-methylation (H3K27me3), an epigenetic modification associated with gene repression. H3K27me3 is enriched at the promoters of a large cohort of developmental genes in embryonic st
Externí odkaz:
https://doaj.org/article/574f3f19f07140c2b82578256c21373d
Publikováno v:
Nature structuralmolecular biology. 28(5)
RNAPII pausing immediately downstream of the transcription start site (TSS) is a critical rate limiting step at most metazoan genes that allows fine-tuning of gene expression in response to diverse signals1–5. During pause-release, RNA Polymerase I
Autor:
Joon Ho Kang, Marguerite Blair, Pema Maretich, Chia-Wei Cheng, Adam Antebi, Sean J. Morrison, Joachim D. Steiner, Laurie A. Boyer, Christina Roberts, Angelika Amon, Jacqueline A. Lees, Jette Lengefeld, Kyra Majors, Melanie R. McReynolds, Scott R. Manalis, Hannah R. Hagen, Teemu P. Miettinen, Ömer H. Yilmaz, Emily Sullivan
Stem cells are remarkably small in size. Whether small size is important for stem cell function is unknown. We find that murine hematopoietic stem cells (HSCs) enlarge under conditions known to decrease stem cell function. This decreased fitness of l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24a7dfd1fa21c9d83fbc6da6eb5f60d1
https://doi.org/10.1101/2020.10.27.355388
https://doi.org/10.1101/2020.10.27.355388
Autor:
Michael A Lodato, Christopher W Ng, Joseph A Wamstad, Albert W Cheng, Kevin K Thai, Ernest Fraenkel, Rudolf Jaenisch, Laurie A Boyer
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003288 (2013)
SOX2 is a master regulator of both pluripotent embryonic stem cells (ESCs) and multipotent neural progenitor cells (NPCs); however, we currently lack a detailed understanding of how SOX2 controls these distinct stem cell populations. Here we show by
Externí odkaz:
https://doaj.org/article/02a27a75c5fb421e971eff1e44cbf4c4