Zobrazeno 1 - 10
of 219 663
pro vyhledávání: '"Laurie A"'
Autor:
Ching Ann Tee, Daniel Ninio Roxby, Rashidah Othman, Vinitha Denslin, Kiseer Sideeq Bhat, Zheng Yang, Jongyoon Han, Lisa Tucker-Kellogg, Laurie A. Boyer
Publikováno v:
Stem Cell Research & Therapy, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Background Articular cartilage degeneration can result from injury, age, or arthritis, causing significant joint pain and disability without surgical intervention. Currently, the only FDA cell-based therapy for articular cartilage injury is
Externí odkaz:
https://doaj.org/article/56e50eeac7a14d26a37598d668513e8e
Autor:
Joseph Walton, Angel S. N. Ng, Karen Arevalo, Anthony Apostoli, Jalna Meens, Christina Karamboulas, Jonathan St-Germain, Panagiotis Prinos, Julia Dmytryshyn, Eric Chen, Cheryl H. Arrowsmith, Brian Raught, Laurie Ailles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In addition to the ubiquitous loss of the VHL gene in clear cell renal cell carcinoma (ccRCC), co-deletions of chromatin-regulating genes are common drivers of tumorigenesis, suggesting potential vulnerability to epigenetic manipulation. A l
Externí odkaz:
https://doaj.org/article/c3c9ce48e93f480088b52266f80ffb05
Autor:
Agnes Cheong, Florin Craciun, Hervé Husson, Joseph Gans, Javier Escobedo, Yi-Chien Chang, Lilu Guo, Mariana Goncalves, Nathan Kaplan, Laurie A. Smith, Sarah Moreno, Joseph Boulanger, Shiguang Liu, Jacqueline Saleh, Mindy Zhang, Anna S. Blazier, Weiliang Qiu, Andrew Macklin, Tejaswi Iyyanki, Clément Chatelain, Shameer Khader, Thomas A. Natoli, Oxana Ibraghimov-Beskrovnaya, Dimitry Ofengeim, Jonathan D. Proto
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-15 (2024)
Abstract While significant advances have been made in understanding renal pathophysiology, less is known about the role of glycosphingolipid (GSL) metabolism in driving organ dysfunction. Here, we used a small molecule inhibitor of glucosylceramide s
Externí odkaz:
https://doaj.org/article/68828197b6744988a8444a603fea8bde
Publikováno v:
Pilot and Feasibility Studies, Vol 10, Iss 1, Pp 1-14 (2024)
Abstract Background People with mobility limitations have a disproportionately higher rate of acquiring secondary conditions such as obesity, cardiovascular comorbidity, pain, fatigue, depression, deconditioning, and type 2 diabetes. These conditions
Externí odkaz:
https://doaj.org/article/74b852721d37408f81e3aa210441ed01
Autor:
The OpenSAFELY Collaborative, Colm D. Andrews, Rohini Mathur, Jon Massey, Robin Park, Helen J. Curtis, Lisa Hopcroft, Amir Mehrkar, Seb Bacon, George Hickman, Rebecca Smith, David Evans, Tom Ward, Simon Davy, Peter Inglesby, Iain Dillingham, Steven Maude, Thomas O’Dwyer, Ben F. C. Butler-Cole, Lucy Bridges, Chris Bates, John Parry, Frank Hester, Sam Harper, Jonathan Cockburn, Ben Goldacre, Brian MacKenna, Laurie A. Tomlinson, Alex J. Walker, William J. Hulme
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Ethnicity is known to be an important correlate of health outcomes, particularly during the COVID-19 pandemic, where some ethnic groups were shown to be at higher risk of infection and adverse outcomes. The recording of patients
Externí odkaz:
https://doaj.org/article/7e06336001144ee0a8f27b8ef84bccf6
Autor:
Liang-Yu Lin, Alasdair D. Henderson, Oliver Carlile, Iain Dillingham, Ben F. C. Butler-Cole, Michael Marks, Andrew Briggs, Mark Jit, Laurie A. Tomlinson, Chris Bates, John Parry, Sebastian C. J. Bacon, Ben Goldacre, Amir Mehrkar, Brian MacKenna, The OpenSAFELY Collaborative, Rosalind M. Eggo, Emily Herrett
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-13 (2024)
Abstract Background Long COVID potentially increases healthcare utilisation and costs. However, its impact on the NHS remains to be determined. Methods This study aims to assess the healthcare utilisation of individuals with long COVID. With the appr
Externí odkaz:
https://doaj.org/article/d9c8f6eba19f4b7ba7ce3bd6affa1bcb
Autor:
Jennifer K Quint, Ben Goldacre, Henrik Toft Sørensen, Laurie A Tomlinson, Srinivasa Vittal Katikireddi, Rohini Mathur, Helena Carreira, Charlotte Warren-Gash, Lars Pedersen, Sinéad M Langan, Kathryn E Mansfield, Bang Zheng, Brian MacKenna, Ruth E Costello, Joseph F Hayes, Amir Mehrkar, Jan P Vandenbroucke, Sebastian Bacon, John Tazare, Viyaasan Mahalingasivam, Patrick Bidulka, Alasdair D Henderson, Dominik Manuel Piehlmaier, Angel Yun Sum Wong, The LH&W NCS (or CONVALESCENCE) Collaborative, The OpenSAFELY Consortium
Publikováno v:
BMJ Open, Vol 14, Iss 10 (2024)
Objectives To examine the impact of the COVID-19 pandemic on deprivation-related inequalities in hospitalisations for cardiovascular disease (CVD) conditions in Denmark and England between March 2018 and December 2021.Design Time-series studies in En
Externí odkaz:
https://doaj.org/article/eb76b3e1144a49809793ef4a93dfe0ca
Autor:
Laurie A. Lee, Augustina Okpere, Dori-Ann Martin, Meagan Mahoney, Lee James, Yaron Avitzur, Bailey Piggott, Christopher Tomlinson, Simon Urschel, Lorraine Hamiwka
Publikováno v:
Frontiers in Transplantation, Vol 3 (2024)
IntroductionSolid organ transplantation in children is a lifesaving therapy, however, pediatric organ donation rates remain suboptimal.MethodsWe conducted a cross-sectional survey of Canadian organ donation organizations (ODOs) and pediatric transpla
Externí odkaz:
https://doaj.org/article/b44bfe56f34c4e278602cc8ad8e3c9c8
Autor:
Lili Wei, Elaine Butterly, Peter Hanlon, Houra Haghpanahan, Robert Lindsay, Amanda I Adler, Luke A K Blackbourn, Sofia Dias, Katherine Hughes, Stuart McGurnaghan, John Petrie, Naveed Sattar, Laurie A Tomlinson, Nicky Welton, Sarah Wild, Jim Lewsey, David McAllister
Publikováno v:
International Journal of Population Data Science, Vol 9, Iss 5 (2024)
Healthcare commissioners and those making reimbursement decisions require data on the “natural history” of diseases to estimate quantities such as life expectancy and quality of life. However, such data are commonly acquired from unrepresentative
Externí odkaz:
https://doaj.org/article/75af3b9526f5493d95d69f252d1c3660
Autor:
David M. Leone, Matthew J. Magoon, Neha Arunkumar, Laurie A. Soine, Elizabeth C. Bayley, Patrick M. Boyle, Jonathan Buber
Publikováno v:
International Journal of Cardiology Congenital Heart Disease, Vol 17, Iss , Pp 100539- (2024)
Background: Cardiopulmonary exercise testing (CPET) is used in evaluation of repaired tetralogy of Fallot (rTOF), particularly for pulmonary valve replacement need. Oxygen pulse (O2P) is the CPET surrogate for stroke volume and peripheral oxygen extr
Externí odkaz:
https://doaj.org/article/f35e866eadd84c17990e1e39324db761