Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Laurie, Ailles"'
Autor:
Nasim Sarrami, Bryce Nelson, Samantha Leier, John Wilson, Conrad Chan, Jalna Meens, Teesha Komal, Laurie Ailles, Melinda Wuest, Michael Schultz, Afsaneh Lavasanifar, Raymond M. Reilly, Frank Wuest
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-13 (2024)
Abstract Background The objective of this research was the development and evaluation of 203Pb-labelled panitumumab (203Pb-PSC-panitumumab) as an immuno-SPECT radioligand for the detection of EGFR + head and neck squamous cell carcinoma (HNSCC) in a
Externí odkaz:
https://doaj.org/article/dbec871ee73f42fbb3a3914c8584d87c
Autor:
Joseph Walton, Angel S. N. Ng, Karen Arevalo, Anthony Apostoli, Jalna Meens, Christina Karamboulas, Jonathan St-Germain, Panagiotis Prinos, Julia Dmytryshyn, Eric Chen, Cheryl H. Arrowsmith, Brian Raught, Laurie Ailles
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract In addition to the ubiquitous loss of the VHL gene in clear cell renal cell carcinoma (ccRCC), co-deletions of chromatin-regulating genes are common drivers of tumorigenesis, suggesting potential vulnerability to epigenetic manipulation. A l
Externí odkaz:
https://doaj.org/article/c3c9ce48e93f480088b52266f80ffb05
Autor:
Subhanwita Sarkar, Ayan Chanda, Rutvij A. Khanolkar, Meghan Lambie, Laurie Ailles, Scott V. Bratman, Aru Narendran, Pinaki Bose
Publikováno v:
Biomedicines, Vol 12, Iss 3, p 503 (2024)
Polo-like-kinase-1 (PLK-1) is a serine/threonine kinase that regulates the cell cycle and acts as an oncogene in multiple cancers, including oral squamous cell carcinoma (OSCC). The loss of PLK-1 can inhibit growth and induce apoptosis, making it an
Externí odkaz:
https://doaj.org/article/9c56982e74b64f5faa7f48ce5af435cd
Autor:
Anthony Ku, Misaki Kondo, Zhongli Cai, Jalna Meens, Min Rong Li, Laurie Ailles, Raymond M. Reilly
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-22 (2021)
Abstract Background Epidermal growth factor receptors (EGFR) are overexpressed on many head and neck squamous cell carcinoma (HNSCC). Radioimmunotherapy (RIT) with F(ab')2 of the anti-EGFR monoclonal antibody panitumumab labeled with the β-particle
Externí odkaz:
https://doaj.org/article/87d0c0930f2949c9a68e8c753d2b9c38
Autor:
Kara M. Ruicci, Jalna Meens, Paul Plantinga, William Stecho, Nicole Pinto, John Yoo, Kevin Fung, Danielle MacNeil, Joe S. Mymryk, John W. Barrett, Christopher J. Howlett, Paul C. Boutros, Laurie Ailles, Anthony C. Nichols
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-18 (2020)
Abstract Background Aberrant activation of the phosphatidylinositol 3-kinase (PI3K) pathway is common in many malignancies, including head and neck squamous cell carcinoma (HNSCC). Despite pre-clinical and clinical studies, outcomes from targeting th
Externí odkaz:
https://doaj.org/article/3551d8a27ebe46f4ba35d980ed3dd3e5
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-10 (2020)
Abstract Background Clear cell renal cell carcinoma (ccRCC) is a markedly heterogeneous disease in many aspects, including the tumour microenvironment. Our previous study showed the importance of the tumour microenvironment in ccRCC xeno-transplant s
Externí odkaz:
https://doaj.org/article/c7841f902b31449fa1f2fe13942a0cc0
Akademický článek
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Publikováno v:
Biomolecules, Vol 13, Iss 1, p 75 (2022)
The tumor microenvironment has recently emerged as a critical component of high-grade serous ovarian cancer (HGSC) disease progression. Specifically, cancer-associated fibroblasts (CAFs) have been recognized as key players in various pro-oncogenic pr
Externí odkaz:
https://doaj.org/article/4079e8a3cdf04e09a4a08f5e539dddb5
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100024- (2020)
Summary: This protocol provides the steps required for the establishment of patient-derived xenograft (PDX) tumors for head and neck squamous cell carcinomas (HNSCCs) and their utility in examining drug responses. PDXs recapitulate the heterogeneity
Externí odkaz:
https://doaj.org/article/59043720aec6428fadeb9e2e11a2bb49
Autor:
Mauricio Medrano, Laudine Communal, Kevin R. Brown, Marcin Iwanicki, Josee Normand, Joshua Paterson, Fabrice Sircoulomb, Paul Krzyzanowski, Marian Novak, Sasha A. Doodnauth, Fernando Suarez Saiz, Jane Cullis, Rima Al-awar, Benjamin G. Neel, John McPherson, Ronny Drapkin, Laurie Ailles, Anne-Marie Mes-Massons, Robert Rottapel
Publikováno v:
Cell Reports, Vol 18, Iss 10, Pp 2343-2358 (2017)
The degree of genetic aberrations characteristic of high-grade serous ovarian cancer (HGSC) makes identification of the molecular features that drive tumor progression difficult. Here, we perform genome-wide RNAi screens and comprehensive expression
Externí odkaz:
https://doaj.org/article/5c7651cc95f944028100473e51fbc84b