Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Lauriane Lecoq"'
Autor:
Sara Pfister, Julius Rabl, Thomas Wiegand, Simone Mattei, Alexander A. Malär, Lauriane Lecoq, Stefan Seitz, Ralf Bartenschlager, Anja Böckmann, Michael Nassal, Daniel Boehringer, Beat H. Meier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Nackednaviruses and hepatitis B virus (HBV) have a common non-enveloped viral ancestor. While HBV acquired an envelope during evolution, nackednaviruses remained non-enveloped. Here, Pfister et al. apply CryoEM and NMR to characterize the capsid stru
Externí odkaz:
https://doaj.org/article/8c260d6601c645e1a548bd8179f2151e
Autor:
Lauriane Lecoq, Louis Brigandat, Rebecca Huber, Marie-Laure Fogeron, Shishan Wang, Marie Dujardin, Mathilde Briday, Thomas Wiegand, Morgane Callon, Alexander Malär, David Durantel, Dara Burdette, Jan Martin Berke, Beat H. Meier, Michael Nassal, Anja Böckmann
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Hepatitis B virus (HBV) capsid assembly modulators (CAM) represent a recent class of anti-HBV antivirals. Structural approaches provide limited conformational information on the CAM-induced off-path assemblies. Here, authors use solid-state NMR to es
Externí odkaz:
https://doaj.org/article/f91900044dae4b51a0f7e494c6893cce
Autor:
Marie-Laure Fogeron, Lauriane Lecoq, Laura Cole, Roland Montserret, Guillaume David, Adeline Page, Frédéric Delolme, Michael Nassal, Anja Böckmann
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
We here establish the phosphorylation sites in the human hepatitis B virus (HBV) large envelope protein (L). L is involved in several functionally important interactions in the viral life cycle, including with the HBV cellular receptor, HBV capsid, H
Externí odkaz:
https://doaj.org/article/fe3bd340ead241f8876af355835756df
Autor:
Alexander A. Malär, Morgane Callon, Albert A. Smith, Shishan Wang, Lauriane Lecoq, Carolina Pérez-Segura, Jodi A. Hadden-Perilla, Anja Böckmann, Beat H. Meier
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
Protein plasticity and dynamics are important aspects of their function. Here we use solid-state NMR to experimentally characterize the dynamics of the 3.5 MDa hepatitis B virus (HBV) capsid, assembled from 240 copies of the Cp149 core protein. We me
Externí odkaz:
https://doaj.org/article/045695b8c91b412abf8c30d4732030fd
Autor:
Nadide Altincekic, Sophie Marianne Korn, Nusrat Shahin Qureshi, Marie Dujardin, Martí Ninot-Pedrosa, Rupert Abele, Marie Jose Abi Saad, Caterina Alfano, Fabio C. L. Almeida, Islam Alshamleh, Gisele Cardoso de Amorim, Thomas K. Anderson, Cristiane D. Anobom, Chelsea Anorma, Jasleen Kaur Bains, Adriaan Bax, Martin Blackledge, Julius Blechar, Anja Böckmann, Louis Brigandat, Anna Bula, Matthias Bütikofer, Aldo R. Camacho-Zarco, Teresa Carlomagno, Icaro Putinhon Caruso, Betül Ceylan, Apirat Chaikuad, Feixia Chu, Laura Cole, Marquise G. Crosby, Vanessa de Jesus, Karthikeyan Dhamotharan, Isabella C. Felli, Jan Ferner, Yanick Fleischmann, Marie-Laure Fogeron, Nikolaos K. Fourkiotis, Christin Fuks, Boris Fürtig, Angelo Gallo, Santosh L. Gande, Juan Atilio Gerez, Dhiman Ghosh, Francisco Gomes-Neto, Oksana Gorbatyuk, Serafima Guseva, Carolin Hacker, Sabine Häfner, Bing Hao, Bruno Hargittay, K. Henzler-Wildman, Jeffrey C. Hoch, Katharina F. Hohmann, Marie T. Hutchison, Kristaps Jaudzems, Katarina Jović, Janina Kaderli, Gints Kalniņš, Iveta Kaņepe, Robert N. Kirchdoerfer, John Kirkpatrick, Stefan Knapp, Robin Krishnathas, Felicitas Kutz, Susanne zur Lage, Roderick Lambertz, Andras Lang, Douglas Laurents, Lauriane Lecoq, Verena Linhard, Frank Löhr, Anas Malki, Luiza Mamigonian Bessa, Rachel W. Martin, Tobias Matzel, Damien Maurin, Seth W. McNutt, Nathane Cunha Mebus-Antunes, Beat H. Meier, Nathalie Meiser, Miguel Mompeán, Elisa Monaca, Roland Montserret, Laura Mariño Perez, Celine Moser, Claudia Muhle-Goll, Thais Cristtina Neves-Martins, Xiamonin Ni, Brenna Norton-Baker, Roberta Pierattelli, Letizia Pontoriero, Yulia Pustovalova, Oliver Ohlenschläger, Julien Orts, Andrea T. Da Poian, Dennis J. Pyper, Christian Richter, Roland Riek, Chad M. Rienstra, Angus Robertson, Anderson S. Pinheiro, Raffaele Sabbatella, Nicola Salvi, Krishna Saxena, Linda Schulte, Marco Schiavina, Harald Schwalbe, Mara Silber, Marcius da Silva Almeida, Marc A. Sprague-Piercy, Georgios A. Spyroulias, Sridhar Sreeramulu, Jan-Niklas Tants, Kaspars Tārs, Felix Torres, Sabrina Töws, Miguel Á. Treviño, Sven Trucks, Aikaterini C. Tsika, Krisztina Varga, Ying Wang, Marco E. Weber, Julia E. Weigand, Christoph Wiedemann, Julia Wirmer-Bartoschek, Maria Alexandra Wirtz Martin, Johannes Zehnder, Martin Hengesbach, Andreas Schlundt
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium
Externí odkaz:
https://doaj.org/article/201170fa84b8450e9b468d9fb4480774
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Cell-free protein synthesis (CFPS) systems are gaining more importance as universal tools for basic research, applied sciences, and product development with new technologies emerging for their application. Huge progress was made in the field of synth
Externí odkaz:
https://doaj.org/article/cec90ce4fd6348919b30aa0fc268b726
Autor:
Guillaume David, Marie-Laure Fogeron, Roland Montserret, Lauriane Lecoq, Adeline Page, Frédéric Delolme, Michael Nassal, Anja Böckmann
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Wheat-germ cell-free protein synthesis (WG-CFPS) is a potent platform for the high-yield production of proteins. It is especially of interest for difficult-to-express eukaryotic proteins, such as toxic and transmembrane proteins, and presents an impo
Externí odkaz:
https://doaj.org/article/0406fb56666f4df58bed724600bedeae
Autor:
Shishan Wang, Marie-Laure Fogeron, Maarten Schledorn, Marie Dujardin, Susanne Penzel, Dara Burdette, Jan Martin Berke, Michael Nassal, Lauriane Lecoq, Beat H. Meier, Anja Böckmann
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Modulation of capsid assembly by small molecules has become a central concept in the fight against viral infection. Proper capsid assembly is crucial to form the high molecular weight structures that protect the viral genome and that, often in concer
Externí odkaz:
https://doaj.org/article/f3ba5dd1450b4b619e4a96f9091e6647
Autor:
Lauriane Lecoq, Maarten Schledorn, Shishan Wang, Susanne Smith-Penzel, Alexander A. Malär, Morgane Callon, Michael Nassal, Beat H. Meier, Anja Böckmann
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
We sequentially assigned the fully-protonated capsids made from core proteins of the Hepatitis B virus using proton detection at 100 kHz magic-angle spinning (MAS) in 0.7 mm rotors and compare sensitivity and assignment completeness to previously obt
Externí odkaz:
https://doaj.org/article/71b16c6dac574f3db8ac6f6dac83d843
Publikováno v:
PLoS Pathogens, Vol 14, Iss 12, p e1007488 (2018)
Hepatitis B virus (HBV) replicates its 3 kb DNA genome through capsid-internal reverse transcription, initiated by assembly of 120 core protein (HBc) dimers around a complex of viral pregenomic (pg) RNA and polymerase. Following synthesis of relaxed
Externí odkaz:
https://doaj.org/article/19468640e13f47629b1ababa2397590b