Functional Toll-Like Receptor (TLR)2 polymorphisms in the susceptibility to inflammatory bowel disease.

Autor: Helga Paula Török, Victor Bellon, Astrid Konrad, Martin Lacher, Laurian Tonenchi, Matthias Siebeck, Stephan Brand, Enrico Narciso De Toni

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175180 (2017)

BACKGROUND:The recent genome-wide association studies (GWAS) in inflammatory bowel disease (IBD) suggest significant genetic overlap with complex mycobacterial diseases like tuberculosis or leprosy. TLR variants have previously been linked to suscept

Externí odkaz: https://doaj.org/article/69c51bcdb4154271a317ae9893f351f7

The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease

Autor: Helga-Paula Török, Christian Folwaczny, Vanessa Beynon, Molla Y. Teshome, Jürgen Glas, Matthias Folwaczny, Joerg T. Epplen, Thomas Mussack, Wolfram Klein, Laurian Tonenchi, Sebastian Cotofana, Uwe Schiemann, Elisabeth H. Weiss, Thomas Griga, Martin Wetzke

Publikováno v: Glas, Jürgen; Török, Helga-Paula; Tonenchi, Laurian; Wetzke, Martin; Beynon, Vanessa; Teshome, Molla Y; Cotofana, Sebastian; Schiemann, Uwe; Griga, Thomas; Klein, Wolfram; Epplen, Joerg T; Folwaczny, Christian; Folwaczny, Matthias; Mussack, Thomas; Weiss, Elisabeth H (2007). The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. International immunology, 19(5), pp. 621-6. Oxford: Oxford University Press 10.1093/intimm/dxm027

HLA-G is a non-classical MHC class Ib molecule predominantly expressed in cytotrophoblasts and under pathological conditions also in chronically inflamed and in malignant tissues. Recently an increased expression of HLA-G was found in ulcerative coli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf8667edd3fd7d10afb6600598138ea
http://doc.rero.ch/record/304734/files/dxm027.pdf

A645G (Lys216Glu) polymorphism of the bactericidal/permeability-increasing protein gene in periodontal disease

Autor: Laurian Tonenchi, H. P. Török, A. Euba, Christian Folwaczny, M. Folwaczny, S. Hamann, J. Glas, O. Malachova

Publikováno v: International Journal of Immunogenetics. 33:255-260

Summary Bactericidal/permeability-increasing protein (BPI) is a member of the pattern recognition receptors of the innate immune system and recognizes lipopolysaccharides (LPS), a bacterial component belonging to the pathogen-associated molecular pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c5cd38e8d8c8c28a30ec0781066eb4
https://doi.org/10.1111/j.1744-313x.2006.00608.x

Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease

Autor: Cornelia Tillack, Uwe Schiemann, Thomas Griga, Günter Brünnler, Jörg T. Epplen, Julia Seiderer, Christian Folwaczny, Stephan Brand, Peter Lohse, Bertram Müller-Myhsok, Laurian Tonenchi, Thomas Ochsenkühn, C. Neugebauer, Fabian Schnitzler, Wolfram Klein, Matthias Folwaczny, O. Limbersky, Peter Jagiello, Helga-Paula Török, J. Glas

Publikováno v: Gut. 54:1421-1427

Background and aims: Recent data suggest identification of causal genetic variants for inflammatory bowel disease in the DLG5 gene and in the organic cation transporter (OCTN) cluster, both situated in previously described linkage regions. Patients a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c9da6e77782abad1c6741c79e9a3c52b
https://doi.org/10.1136/gut.2005.066340

rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants

Autor: Stephan Brand, Helga-Paula Török, Julia Seiderer, Christine Grassl, Martin Wetzke, Kerstin C. Maier, Jürgen Glas, Simone Pfennig, Thomas Mussack, Uwe Schiemann, Bertram Müller-Myhsok, Julia Dambacher, Wolfram Klein, Astrid Konrad, Jörg T. Epplen, Christian Folwaczny, Thomas Ochsenkühn, Thomas Griga, Laurian Tonenchi, Peter Lohse, Matthias Folwaczny, Burkhard Göke, Silke Schmechel

Publikováno v: PLoS ONE, Vol 2, Iss 9, p e819 (2007)
PLoS ONE

BACKGROUND: The IL23R gene has been identified as a susceptibility gene for inflammatory bowel disease (IBD) in the North American population. The aim of our study was to test this association in a large German IBD cohort and to elucidate potential i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5cf394183c24d67192caaf35e846b4
http://europepmc.org/articles/PMC1950565?pdf=render