Functional Toll-Like Receptor (TLR)2 polymorphisms in the susceptibility to inflammatory bowel disease.

Autor: Helga Paula Török, Victor Bellon, Astrid Konrad, Martin Lacher, Laurian Tonenchi, Matthias Siebeck, Stephan Brand, Enrico Narciso De Toni

Publikováno v: PLoS ONE, Vol 12, Iss 4, p e0175180 (2017)

BACKGROUND:The recent genome-wide association studies (GWAS) in inflammatory bowel disease (IBD) suggest significant genetic overlap with complex mycobacterial diseases like tuberculosis or leprosy. TLR variants have previously been linked to suscept

Externí odkaz: https://doaj.org/article/69c51bcdb4154271a317ae9893f351f7

The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease

Autor: Helga-Paula Török, Christian Folwaczny, Vanessa Beynon, Molla Y. Teshome, Jürgen Glas, Matthias Folwaczny, Joerg T. Epplen, Thomas Mussack, Wolfram Klein, Laurian Tonenchi, Sebastian Cotofana, Uwe Schiemann, Elisabeth H. Weiss, Thomas Griga, Martin Wetzke

Publikováno v: Glas, Jürgen; Török, Helga-Paula; Tonenchi, Laurian; Wetzke, Martin; Beynon, Vanessa; Teshome, Molla Y; Cotofana, Sebastian; Schiemann, Uwe; Griga, Thomas; Klein, Wolfram; Epplen, Joerg T; Folwaczny, Christian; Folwaczny, Matthias; Mussack, Thomas; Weiss, Elisabeth H (2007). The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease. International immunology, 19(5), pp. 621-6. Oxford: Oxford University Press 10.1093/intimm/dxm027

HLA-G is a non-classical MHC class Ib molecule predominantly expressed in cytotrophoblasts and under pathological conditions also in chronically inflamed and in malignant tissues. Recently an increased expression of HLA-G was found in ulcerative coli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf8667edd3fd7d10afb6600598138ea
http://doc.rero.ch/record/304734/files/dxm027.pdf

A645G (Lys216Glu) polymorphism of the bactericidal/permeability-increasing protein gene in periodontal disease

Autor: Laurian Tonenchi, H. P. Török, A. Euba, Christian Folwaczny, M. Folwaczny, S. Hamann, J. Glas, O. Malachova

Publikováno v: International Journal of Immunogenetics. 33:255-260

Summary Bactericidal/permeability-increasing protein (BPI) is a member of the pattern recognition receptors of the innate immune system and recognizes lipopolysaccharides (LPS), a bacterial component belonging to the pathogen-associated molecular pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c5cd38e8d8c8c28a30ec0781066eb4
https://doi.org/10.1111/j.1744-313x.2006.00608.x

The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population

Autor: Silke Schmechel, Christian Folwaczny, D. Roeske, Dirk Haller, Burkhard Göke, Julia Dambacher, Bertram Müller-Myhsok, Jürgen Glas, Astrid Konrad, Thomas Mussack, Jörg T. Epplen, Julia Seiderer, Frieder Schroff, Martin Wetzke, Thomas Griga, Stephan Brand, Thomas Ochsenkühn, Laurian Tonenchi, Peter Lohse, Matthias Folwaczny, Simone Pfennig, Helga-Paula Török, Wolfram Klein

Publikováno v: The American journal of gastroenterology. 103(3)

We analyzed ATG16L1, a recently identified Crohn's disease (CD) susceptibility gene, in a large cohort with inflammatory bowel disease (IBD) including potential interactions with other IBD genes as well as factors regulating its gene expression.Genom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a4422257876d65ba8495a73ae3d755
https://pubmed.ncbi.nlm.nih.gov/18162085

Role of the NFKB1 -94ins/delATTG promoter polymorphism in IBD and potential interactions with polymorphisms in the CARD15/NOD2, IKBL, and IL-1RN genes

Autor: Thomas Ochsenkühn, Stephan Brand, Bertram Müller-Myhsok, Martin Wetzke, Julia Seiderer, Fabian Schnitzler, Peter Lohse, Helga-Paula Török, Joerg T. Epplen, Laurian Tonenchi, Thomas Griga, Matthias Folwaczny, Christian Folwaczny, Wolfram Klein, Uwe Schiemann, Jürgen Glas, Thomas Mussack

BACKGROUND: Recently, an association of the NFKB1 polymorphism -94ins/delATTG with ulcerative colitis (UC) has been reported. This 4-bp insertion/deletion polymorphism is localized in the promoter region of the NFKB1 gene and appears to be functional

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0420a8ffcdcf6d598070436ce17328c6