Výsledky vyhledávání - "Lauri Vuorilehto"

Pharmacodynamic and pharmacokinetic profile of SM‐1, a triple‐drug combination to increase total sleep time

Autor: Lan Bo Chen, Jaana Suopanki-Lalowski, Thomas Dahl, Lauri Vuorilehto, Axel Meierjohann, Marju Valge, Hannu Mikola, Mika Scheinin, Thomas Roth, Antti Puhakka, Zsófia Lovró

Publikováno v: Human Psychopharmacology: Clinical and Experimental. 34

OBJECTIVE The primary objective was to characterize the pharmacokinetics and pharmacodynamics of SM-1 after administration of a single oral dose to healthy volunteers in a placebo-controlled double-blind trial of daytime sedation. Secondary objective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f914ce51954c481ad3beed525df2449
https://doi.org/10.1002/hup.2716

Zobrazit plný text záznamu

Sensitivity of [11C]ORM-13070 to increased extracellular noradrenaline in the CNS – a PET study in human subjects

Autor: Pauliina Luoto, Harry Scheinin, Juha Rouru, Jussi Lehto, Lauri Vuorilehto, Jarkko Johansson, Mika Scheinin, Eveliina Arponen

Publikováno v: Psychopharmacology. 232:4169-4178

No validated methods have been available for studying brain noradrenergic neurotransmission in vivo in humans. Positron emission tomography (PET) radiotracers are widely used in clinical drug development targeted to brain receptors and can also in so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80050b03b2781f48ce83d3dd8356c96b
https://doi.org/10.1007/s00213-015-3941-y

Zobrazit plný text záznamu

Validation of [11C]ORM-13070 as a PET tracer for alpha2c-adrenoceptors in the human brain

Autor: Vesa Oikonen, Pauliina Luoto, Jussi Lehto, Mika Scheinin, Juha Rouru, Sjoerd J. Finnema, Juha O. Rinne, Christer Halldin, Jukka Sallinen, Tarja Naukkarinen, Eveliina Arponen, Harry Scheinin, Jarkko Johansson, M. Hirvonen, Jukka Kemppainen, Lauri Vuorilehto

Publikováno v: Synapse. 69:172-181

This study explored the use of the α2C-adrenoceptor PET tracer [11C]ORM-13070 to monitor α2C-AR occupancy in the human brain. The subtype-nonselective α2-AR antagonist atipamezole was administered to eight healthy volunteer subjects to determine i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9db1cab70f1b7c5cd3f6eaddaaaab6c6
https://doi.org/10.1002/syn.21798

Zobrazit plný text záznamu

Effect of synthesis parameters of the sol–gel-processed spray-dried silica gel microparticles on the release rate of dexmedetomidine

Autor: Martti Marvola, Pirjo Kortesuo, Minna Kangas, Tiina Leino, Lauri Vuorilehto, Mika Jokinen, Antti Yli-Urpo, Sirpa Laakso, Juha Kiesvaara, Manja Ahola

Publikováno v: Biomaterials. 23:2795-2801

The objective of this study was to evaluate the possibilities to control the release rate of dexmedetomidine (DMED) from different spray-dried silica gel microparticle formulations. Microparticles were prepared by spray drying a silica sol polymer so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ae52395110f156f343538f13e3615e
https://doi.org/10.1016/s0142-9612(02)00016-9

Zobrazit plný text záznamu

Detomidine and the combination of detomidine and MK-467, a peripheral alpha-2 adrenoceptor antagonist, as premedication in horses anaesthetized with isoflurane

Autor: Lauri Vuorilehto, Kati Salla, Soile Anja Eliisa Pakkanen, Annemarie de Vries, Outi Vainio, Mika Scheinin, Marja Raekallio, Anna Mykkänen

Publikováno v: Veterinary anaesthesia and analgesia. 42(5)

Objective To investigate MK-467 as part of premedication in horses anaesthetized with isoflurane. Study design Experimental, crossover study with a 14 day wash-out period. Animals Seven healthy horses. Methods The horses received either detomidine (2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e13f16c2c8bc4130e654f982630e9a7
https://pubmed.ncbi.nlm.nih.gov/25529045

Zobrazit plný text záznamu

Alkyl-substituted silica gel as a carrier in the controlled release of dexmedetomidine

Autor: Lauri Vuorilehto, Pirjo Kortesuo, Tiina Leino, Manja Ahola, Martti Marvola, Minna Kangas, Juha Kiesvaara, Antti Yli-Urpo, Sirpa Laakso

Publikováno v: Journal of Controlled Release. 76:227-238

The effect of alkyl substitution of the silica xerogel matrix on the release rate of dexmedetomidine was evaluated. Silica sol was processed by either casting or spray drying. When the reaction precursor tetraethylorthosilicate (TEOS) was partially s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1728fa05a6ce67cc71ce13b3e60ee2
https://doi.org/10.1016/s0168-3659(01)00428-x

Zobrazit plný text záznamu

Bioavailability of dexmedetomidine after extravascular doses in healthy subjects

Autor: Jani Penttilä, Lauri Vuorilehto, Markku Anttila, Harry Scheinin, Antti Helminen

Publikováno v: British Journal of Clinical Pharmacology. 56:691-693

Aim To determine the absolute bioavailability of extravascularly administered dexmedetomidine, a novel a2-adrenoceptor agonist, in healthy subjects. Methods Single 2 µg kg−1 doses of dexmedetomidine were given intravenously, intramuscularly, peror

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b24b10e75cc78ef0479bd6f127784ca2
https://doi.org/10.1046/j.1365-2125.2003.01944.x

Zobrazit plný text záznamu

Electronic effects in the electron ionization fragmentations of 2-aryl substituted octahydro-1,3- and -3,1-benzoxazines

Autor: Ferenc Fülöp, Pirjo‐Liisa Lehtelä, Kalevi Pihlaja, Lauri Vuorilehto, Pirjo Vainiotalo, Gábor Bernáth

Publikováno v: Rapid Communications in Mass Spectrometry. 7:465-469

The 70 eV electron ionization mass spectra of 27 2-aryl substituted octahydro-1,3- and -3,1-benzoxazines have been recorded in order to find out how the site and stereochemistry of the ring fusion and especially the nature of the substitutent X on th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a9f405e82d0cce6a61bf08142c5831a2
https://doi.org/10.1002/rcm.1290070613

Zobrazit plný text záznamu

Metabolism of toremifene in the rat

Autor: Reijo Juhani Toivola, Lauri Kangas, Markku Anttila, Maire Eloranta, Hannu Sipilä, Arm Kalapudas, Marja Södervall, Lauri Vuorilehto

Publikováno v: Journal of Steroid Biochemistry. 36:211-215

Toremifene was labelled to a specific activity of about 20 μCi/mmol with tritium at positions 3 and 5 in the para-substituted phenyl ring. At these positions tritium is not eliminated within the metabolic pathways. A mixture of unlabelled and labell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a694155d736ae5c64636b26c1d22cc3d
https://doi.org/10.1016/0022-4731(90)90007-f

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání