Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lauri G. Lintott"'
Autor:
Kevin A. Peterson, Sam Khalouei, Nour Hanafi, Joshua A. Wood, Denise G. Lanza, Lauri G. Lintott, Brandon J. Willis, John R. Seavitt, Robert E. Braun, Mary E. Dickinson, Jacqueline K. White, K. C. Kent Lloyd, Jason D. Heaney, Stephen A. Murray, Arun Ramani, Lauryl M. J. Nutter
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Genome editing with CRISPR-associated (Cas) proteins holds exceptional promise for “correcting” variants causing genetic disease. To realize this promise, off-target genomic changes cannot occur during the editing process. Here, we use w
Externí odkaz:
https://doaj.org/article/f7798291f4934fd091966e0b3ee6f881
Autor:
Elif F. Acar, Luis Santos, Graham Duddy, Adam Caulder, Yann Herault, Joshua A. Wood, Jing Zhao, John R. Seavitt, Masaru Tamura, Martin Hrabĕ de Angelis, Gemma F. Codner, Helen Parkinson, Marie-Christine Birling, Lauryl M. J. Nutter, Jason D. Heaney, Radislav Sedlacek, Brandon J. Willis, Susan Marschall, Kevin A. Peterson, Marina Gertsenstein, Alba Gomez-Segura, Allan Bradley, Je Kyung Seong, Lydia Teboul, Kevin C K Lloyd, Fabio Mammano, Jacqueline K. White, Mary E. Dickinson, Francesco Chiani, Matthew Mackenzie, Robert Braun, Isabel Lorenzo, Colin McKerlie, Wolfgang Wurst, Edward Ryder, Cunxiang Ju, Denise G. Lanza, Ruairidh King, Alessia Gambadoro, Ho Lee, Zhiwei Liu, Ramiro Ramirez-Solis, Ann-Marie Mallon, William C. Skarnes, Xiang Gao, Stephen A. Murray, Francesco J. DeMayo, Lauri G. Lintott, Terrence F. Meehan, Fei Zhou, Hannah Wardle-Jones, Shinya Ayabe, Mark T. Ruhe, Atsushi Yoshiki, Brendan Doe, Peter Matthews, Sara Wells, Hillary Elrick, Claudia Seisenberger, David J. Adams, Jie Zhang, Damien Smedley, Petr Kasparek, Daekee Lee, Leslie O. Goodwin
The International Mouse Phenotyping Consortium (IMPC) is generating and phenotyping null mutations for every protein-coding gene in the mouse1,2. The IMPC now uses Cas9, a programmable RNA-guided nuclease that has revolutionized mouse genome editing3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11a6fcaf64d723a4f023abdfe162834
https://doi.org/10.1101/2021.10.06.463037
https://doi.org/10.1101/2021.10.06.463037
Publikováno v:
Journal of Biological Chemistry. 273:2136-2145
The DNA-dependent protein kinase (DNA-PK) is composed of a large catalytic subunit of approximately 470 kDa (DNA-PKcs) and the DNA-binding protein, Ku. Absence of DNA-PK activity confers sensitivity to x-rays and defects in both DNA double-strand bre
Autor:
John D. Sipley, Kazuyasu Sakaguchi, Lauri G. Lintott, Hong Zhang, Margery A. Connelly, Carl W. Anderson, Susan P. Lees-Miller, Ettore Appella
Publikováno v:
Methods in Protein Structure Analysis ISBN: 9781489910332
Agents that cause damage to DNA (DNA damage-inducing (DDI) agents) arrest cell cycle progression in all eukaryotes from yeast to humans at positions in late G1 and G2 that have become known as “checkpoints” (Hartwell and Weinert, 1989; Murray, 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a80e2856f3329ab267ffa168f0441e18
https://doi.org/10.1007/978-1-4899-1031-8_35
https://doi.org/10.1007/978-1-4899-1031-8_35
Autor:
Rod A. Kelln, Lauri G. Lintott
Publikováno v:
Moleculargeneral genetics : MGG. 222(2-3)
Replication (or partitioning) temperature-sensitive mutants of pKZ1 were isolated and shown to exhibit incompatibility with the resident plasmid (pSLT) of Salmonella typhimurium LT2. Following displacement of pSLT, the mutant plasmids were effectivel
Autor:
Doug W. Chan, Nicholas S. Y. Ting, Joan Allalunis-Turner, Lauri G. Lintott, Susan P. Lees-Miller
Publikováno v:
Radiation Research. 151:414
The DNA-dependent protein kinase (DNA-PK) is composed of a large catalytic subunit (DNA-PKcs) and a DNA-binding protein, Ku. Cells lacking DNA-PK activity are radiosensitive and are defective in DNA double-strand break repair and V(D)J recombination.