Výsledky vyhledávání - "Laurette Malleret"

Synthesis and biological evaluation of pyridazinone derivatives as potential anti-inflammatory agents

Autor: Laurette Malleret, Janos Sapi, Chantal Barberot, Ingrid Allart-Simon, Jean-Philippe Bouillon, Aurélie Moniot, Frédéric Velard, Marie Laronze-Cochard, Eric Hénon, Maurice Médebielle, Stéphane Gérard, Abderrazzaq Bentaher, Tatiana Yegorova

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 146, pp.139-146. ⟨10.1016/j.ejmech.2018.01.035⟩
European Journal of Medicinal Chemistry, 2018, 146, pp.139-146. ⟨10.1016/j.ejmech.2018.01.035⟩

International audience; Cyclic nucleotide phosphodiesterase type 4 (PDE4), that controls intracellular level of cyclic nucleotide cAMP, has aroused scientific attention as a suitable target for anti-inflammatory therapy in respiratory diseases. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63c04fdaba7f3c4e667ea748cea6720
https://hal-normandie-univ.archives-ouvertes.fr/hal-02024470

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Unopposed Cathepsin G, Neutrophil Elastase, and Proteinase 3 Cause Severe Lung Damage and Emphysema

Autor: Julien Wartelle, Dieter E. Jenne, G. Devouassoux, Laurette Malleret, Yves Pacheco, Azzaq Belaaouaj, Nicolas Guyot, Alexandre A. Todorov

Publikováno v: Am. J. Pathol. 184, 985-995 (2014)

Cigarette smoking is a major factor for the development of pulmonary emphysema because it induces abnormal inflammation and a protease-rich local milieu that causes connective tissue breakdown of the lungs. As a result of its capacity to degrade lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a4a8ffabd2921c5a1ff16cf00e922a8
https://doi.org/10.1016/j.ajpath.2014.04.015

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Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium

Autor: Gilles Devouassoux, Laurette Malleret, Timothee Hirche, Julien Wartelle, R. Boxio, Yves Pacheco, Abderrazzaq Bentaher, Brice Lagrange, Béatrice Nawrocki-Raby, Clifford C. Taggart

Publikováno v: Respiratory Research
Respiratory Research, BioMed Central, 2016, 17 (1), pp.129. ⟨10.1186/s12931-016-0449-x⟩
Respiratory Research, 2016, 17 (1), pp.129. ⟨10.1186/s12931-016-0449-x⟩
Boxio, R, Wartelle, J, Nawrocki-Raby, B, Lagrange, B, Malleret, L, Hirche, T, Taggart, C, Pacheco, Y, Devouassoux, G & Bentaher, A 2016, ' Neutrophil elastase cleaves epithelial cadherin in acutely injured lung epithelium ', Respiratory Research, vol. 17, 129 . https://doi.org/10.1186/s12931-016-0449-x

Background In acutely injured lungs, massively recruited polymorphonuclear neutrophils (PMNs) secrete abnormally neutrophil elastase (NE). Active NE creates a localized proteolytic environment where various host molecules are degraded leading to impa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81a99e7ff2f9b6a957f77c2bd14f8da
https://www.hal.inserm.fr/inserm-01382904/document

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Neutrophil Elastase Modulates Cytokine Expression

Autor: Azzaq Belaaouaj, Sophie C. Gangloff, Julien Wartelle, Laurette Malleret, Nicolas Guyot, Rym Benabid, François Lebargy

Publikováno v: Journal of Biological Chemistry. 287:34883-34894

There is accumulating evidence that following bacterial infection, the massive recruitment and activation of the phagocytes, neutrophils, is accompanied with the extracellular release of active neutrophil elastase (NE), a potent serine protease. Usin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc19e864480f01771a85ef6b4a3d4119
https://doi.org/10.1074/jbc.m112.361352

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Synthesis of PDE IVb Inhibitors. 3. Synthesis of (+)-, (−)-, and (±)-7-[3-(Cyclopentyloxy)-4-methoxyphenyl]hexahydro-3H-pyrrolizin-3-one via Reductive Domino Transformations of 3-β-Carbomethoxyethyl-Substituted Six-Membered Cyclic Nitronates

Autor: Alexey Yu, Sukhorukov, Yaroslav D, Boyko, Yulia V, Nelyubina, Stephane, Gerard, Sema L, Ioffe, Vladimir A, Tartakovsky, Laurette, Laurette Malleret, Azzaq, Belaaouaj

Publikováno v: The Journal of Organic Chemistry. 77:5465-5469

Simple three-step asymmetric and racemic syntheses of GlaxoSmithKline's highly potent PDE IVb inhibitor 1 were developed. The suggested approach is based on reductive domino transformations of 3-β-carbomethoxyethyl-substituted six-membered cyclic ni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53241292c566df4fa537c9790d531f15
https://doi.org/10.1021/jo300955n

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Role of polymorphonuclear neutrophils (PMN) in Interleukin-1β (IL-1β) processing during bacterial lung infection: Relevance to cystic fibrosis (CF)

Autor: Gilles Devouassoux, A. Bentaher, Fanny Magne, Laurette Malleret, Brice Lagrange, Yves Pacheco

Publikováno v: 7.3 Cystic Fibrosis.

Rational: In CF, Staphylococcus aureus (S. aureus) and Pseudomonas aeruginosa (P. aeruginosa) infect chronologically host lungs. Although the inflammatory response to bacterial lung infection is characterised by both a neutrophilic response and the p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::39fa924260e5f227917357e4e42033b4
https://doi.org/10.1183/13993003.congress-2015.pa1303

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Neutrophil elastase-mediated increase in airway temperature during inflammation

Publikováno v: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society, 2014, 13 (6), pp.623-631. ⟨10.1016/j.jcf.2014.03.004⟩

International audience; BACKGROUND: How elevated temperature is generated during airway infections represents a hitherto unresolved physiological question. We hypothesized that innate immune defence mechanisms would increase luminal airway temperatur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4034aa1d1110a946e540f0a6932bf5a
https://pubmed.ncbi.nlm.nih.gov/24713593

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Neutrophil Elastase Degrades Cystic Fibrosis Transmembrane Conductance Regulator via Calpains and Disables Channel Function In Vitro and In Vivo

Autor: Emilie Saussereau, Delphine Roussel, Marc Paulais, Pierre Boulanger, Jean-Michel Sallenave, Laurette Malleret, Loïc Guillot, Saw-See Hong, Manon Ruffin, Michel Huerre, Azzaq Belaaouaj, Delphyne Descamps, Aleksander Edelman, Michel Chignard, Mathieu Le Gars, Olivier Tabary

Publikováno v: American Journal of Respiratory and Critical Care Medicine
American Journal of Respiratory and Critical Care Medicine, 2013, 187 (2), pp.170-179. ⟨10.1164/rccm.201205-0875OC⟩
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society, 2013, 187 (2), pp.170-179. ⟨10.1164/rccm.201205-0875OC⟩

Comment in :The yin and yang of cystic fibrosis transmembrane conductance regulator function: implications for chronic lung disease. [Am J Respir Crit Care Med. 2013]; International audience; RATIONALE:Cystic fibrosis transmembrane conductance regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d585eceac22851da0d815c97a7fbefd1
https://www.hal.inserm.fr/inserm-02448131

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Study of cytosolic phospholipase A2 role in COPD exacerbations using a cell culture model

Autor: L. Touqui, F. Benmohamed, N. Freymond, Gilles Devouassoux, Azzaq Belaaouaj, Laurette Malleret, C. Bellanger, Brice Lagrange

Publikováno v: Revue des Maladies Respiratoires. 31:654-655

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb4afbf156235e4b2813462e086269a1
https://doi.org/10.1016/j.rmr.2014.04.023

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Caught at its own game: regulatory small RNA inactivated by an inducible transcript mimicking its target

Autor: Martina Valentini, Nara Figueroa-Bossi, Lionello Bossi, Laurette Malleret

Publikováno v: Genes and Development
Genes and Development, 2009, 23 (17), pp.2004-2015. ⟨10.1101/gad.541609⟩
Genes and Development, Cold Spring Harbor Laboratory Press, 2009, 23 (17), pp.2004-2015. ⟨10.1101/gad.541609⟩

A relevant, yet little recognized feature of antisense regulation is the possibility of switching roles between regulatory and regulated RNAs. Here we show that induction of a Salmonella gene relies on the conversion of a small RNA from effector to r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5be475f19127215009df8b052afd2d4
https://hal.science/hal-02358989

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