Effective Use of Empirical Data for Virtual Screening against APJR GPCR Receptor

Autor: Laura C. E. Manoliu, Adina L. Milac, Eliza C. Martin, Laurentiu N. Spiridon

Publikováno v: Molecules, Vol 26, Iss 4894, p 4894 (2021)
Molecules
Volume 26
Issue 16

Alzheimer’s disease is a neurodegenerative disorder incompatible with normal daily activity, affecting one in nine people. One of its potential targets is the apelin receptor (APJR), a G-protein coupled receptor, which presents considerably high ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaa7804676790979d30dbbbfc29a64b0
https://www.mdpi.com/1420-3049/26/16/4894

Tyrosinase degradation is prevented when EDEM1 lacks the intrinsically disordered region.

Autor: Marioara B Marin, Simona Ghenea, Laurentiu N Spiridon, Gabriela N Chiritoiu, Andrei-Jose Petrescu, Stefana-Maria Petrescu

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42998 (2012)

EDEM1 is a mannosidase-like protein that recruits misfolded glycoproteins from the calnexin/calreticulin folding cycle to downstream endoplasmic reticulum associated degradation (ERAD) pathway. Here, we investigate the role of EDEM1 in the processing

Externí odkaz: https://doaj.org/article/102caa9e862244ed938780359f9a13ac

Genome-wide functional analyses of plant coiled-coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity

Autor: Frank L. W. Takken, Maria Jose Truco, Huaqin Xu, Keri A. Cavanaugh, Andrei-Jose Petrescu, Laurentiu N. Spiridon, Krzysztof Pawłowski, Eliza C. Martin, Dariusz Gozdowski, Richard W Michelmore, Tadeusz Wroblewski

Publikováno v: PLoS Biology, Vol 16, Iss 12, p e2005821 (2018)
PLoS biology, vol 16, iss 12
PLoS Biology, 16(12):e2005821. Public Library of Science
PLOS Biology
PLoS Biology

The ability to induce a defense response after pathogen attack is a critical feature of the immune system of any organism. Nucleotide-binding leucine-rich repeat receptors (NLRs) are key players in this process and perceive the occurrence of nonself-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c746d25bfcae5be7f20a9a34a3227efc
https://doi.org/10.1371/journal.pbio.2005821

Random mutagenesis of the nucleotide‐binding domain ofNRC1 (NB‐LRRRequired for Hypersensitive Response‐Associated Cell Death‐1), a downstream signalling nucleotide‐binding, leucine‐rich repeat (NB‐LRR) protein, identifies gain‐of‐function mutations in the nucleotide‐binding pocket

Autor: Daniela J. Sueldo, Matthieu H. A. J. Joosten, Wladimir I. L. Tameling, Andrei-Jose Petrescu, Mahdere Shimels, Laurentiu N. Spiridon, Octav Caldararu

Publikováno v: New Phytologist. 208:210-223

Plant nucleotide-binding, leucine-rich repeat (NB-LRR) proteins confer immunity to pathogens possessing the corresponding avirulence proteins. Activation of NB-LRR proteins is often associated with induction of the hypersensitive response (HR), a for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9812f9fe8ac5eafee83c44e94fb9aa6d
https://doi.org/10.1111/nph.13459

Three-Dimensional Modeling and Diversity Analysis Reveals Distinct AVR Recognition Sites and Evolutionary Pathways in Wild and Domesticated Wheat Pm3 R Genes

Autor: Hanan Sela, Susanne Brunner, Laurentiu N. Spiridon, Navreet K. Bhullar, Beat Keller, Haim Ashkenazi, Tina Jordan, Andrei-Jose Petrescu, Tzion Fahima

Publikováno v: Molecular Plant-Microbe Interactions®. 27:835-845

The Pm3 gene confers resistance against wheat powdery mildew. Studies of Pm3 diversity have shown that Pm3 alleles isolated from southern populations of wild emmer wheat located in Lebanon, Jordan, Israel, and Syria are more diverse and more distant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7883827338ee379536dfe37bd38ce0
https://doi.org/10.1094/mpmi-01-14-0009-r