Modulation of Overnight Free Fatty Acid and Glucose Concentrations and Their Effect on Postprandial Islet Function and Glucose Metabolism

Autor: Welch, Aa, Wismayer, Ds, Egan, Am, Farahani, Ra, Laurenti, Mc, Cobelli, C, Dalla Man, C, Vella, A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3657::c5956b9ad690cb3442be8c132574d789
https://hdl.handle.net/11577/3471564

Four weeks SGLT2 inhibition improves beta cell function and glucose tolerance without affecting muscle free fatty acid or glucose uptake in subjects with type 2 diabetes.

Autor: Voigt JH; Steno Diabetes Center Aarhus, Aarhus, Denmark., Lauritsen KM; Steno Diabetes Center Aarhus, Aarhus, Denmark.; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.; Danish Diabetes Academy, Odense University Hospital, Odense, Denmark., Pedersen SB; Steno Diabetes Center Aarhus, Aarhus, Denmark.; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark., Hansen TK; Steno Diabetes Center Aarhus, Aarhus, Denmark., Møller N; Steno Diabetes Center Aarhus, Aarhus, Denmark.; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark., Jessen N; Steno Diabetes Center Aarhus, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Laurenti MC; Endocrine Research Unit, Department of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, Minnesota, USA., Dalla Man C; Department of Information Engineering, University of Padua, Padua, Italy., Vella A; Endocrine Research Unit, Department of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, Minnesota, USA., Gormsen LC; Department of Nuclear Medicine and PET Centre, Aarhus University Hospital, Aarhus, Denmark., Søndergaard E; Steno Diabetes Center Aarhus, Aarhus, Denmark.; Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.; Danish Diabetes Academy, Odense University Hospital, Odense, Denmark.; Endocrine Research Unit, Department of Endocrinology, Diabetes and Nutrition, Mayo Clinic, Rochester, Minnesota, USA.

Publikováno v: Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2024 May; Vol. 134 (5), pp. 643-656. Date of Electronic Publication: 2024 Feb 26.

Glucagon-like peptide-1 receptor blockade impairs islet secretion and glucose metabolism in humans.

Autor: Welch AA; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Farahani RA; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Egan AM; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Laurenti MC; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Zeini M; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Vella M; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Bailey KR; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, USA., Cobelli C; Department of Women and Children's Health and., Dalla Man C; Department of Information Engineering, University of Padova, Padova, Italy., Matveyenko A; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, USA., Vella A; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Nov 15; Vol. 133 (22). Date of Electronic Publication: 2023 Nov 15.

Effects of acute changes in fasting glucose and free fatty acid concentrations on indices of β-cell function and glucose metabolism in subjects without diabetes.

Autor: Schembri Wismayer D; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, United States., Laurenti MC; Biomedical Engineering and Physiology Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, Minnesota, United States., Song Y; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, United States., Egan AM; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, United States., Welch AA; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, United States., Bailey KR; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States., Cobelli C; Department of Woman and Child's Health, University of Padova, Padova, Italy., Dalla Man C; Department of Information Engineering, University of Padova, Padova, Italy., Jensen MD; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, United States., Vella A; Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.

Publikováno v: American journal of physiology. Endocrinology and metabolism [Am J Physiol Endocrinol Metab] 2023 Aug 01; Vol. 325 (2), pp. E119-E131. Date of Electronic Publication: 2023 Jun 07.

Differential contribution of alpha and beta cell dysfunction to impaired fasting glucose and impaired glucose tolerance.

Autor: Kohlenberg JD; Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA., Laurenti MC; Biomedical Engineering and Physiology Graduate Program, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, USA., Egan AM; Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA., Wismayer DS; Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA., Bailey KR; Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA., Cobelli C; Department of Women's and Children's Health, University of Padova, Padova, Italy., Man CD; Department of Information Engineering, University of Padova, Padova, Italy., Vella A; Division of Endocrinology, Diabetes and Metabolism, Mayo Clinic College of Medicine, Rochester, MN, USA. vella.adrian@mayo.edu.

Publikováno v: Diabetologia [Diabetologia] 2023 Jan; Vol. 66 (1), pp. 201-212. Date of Electronic Publication: 2022 Sep 16.