Riluzole treatment modulates KCC2 and EAAT-2 receptor expression and Ca2+ accumulation following ventral root avulsion injury

Autor: Krisztián Pajer, Tamás Bellák, Tímea Grósz, Bernát Nógrádi, Roland Patai, József Sinkó, Laurent Vinay, Sylvie Liabeuf, Miklós Erdélyi, Antal Nógrádi

Publikováno v: European Journal of Cell Biology, Vol 102, Iss 2, Pp 151317- (2023)

Avulsion injury results in motoneuron death due to the increased excitotoxicity developing in the affected spinal segments. This study focused on possible short and long term molecular and receptor expression alterations which are thought to be linke

Externí odkaz: https://doaj.org/article/47063d0099374d1ea691c4b32722de20

Sensitization of neonatal rat lumbar motoneuron by the inflammatory pain mediator bradykinin

Autor: Mouloud Bouhadfane, Attila Kaszás, Balázs Rózsa, Ronald M Harris-Warrick, Laurent Vinay, Frédéric Brocard

Publikováno v: eLife, Vol 4 (2015)

Bradykinin (Bk) is a potent inflammatory mediator that causes hyperalgesia. The action of Bk on the sensory system is well documented but its effects on motoneurons, the final pathway of the motor system, are unknown. By a combination of patch-clamp

Externí odkaz: https://doaj.org/article/e853f6392de545cebd6a56699cfd96e9

Prenatal exposure to fenugreek impairs sensorimotor development and the operation of spinal cord networks in mice.

Autor: Loubna Khalki, Saadia Ba M'hamed, Zahra Sokar, Mohamed Bennis, Laurent Vinay, Hélène Bras, Jean-Charles Viemari

Publikováno v: PLoS ONE, Vol 8, Iss 11, p e80013 (2013)

Fenugreek is a medicinal plant whose seeds are widely used in traditional medicine, mainly for its laxative, galactagogue and antidiabetic effects. However, consumption of fenugreek seeds during pregnancy has been associated with a range of congenita

Externí odkaz: https://doaj.org/article/13f5ae7a0a524bd2b8c858ffca6e49e4

Changes in innervation of lumbar motoneurons and organization of premotor network following training of transected adult rats

Autor: Loubna Khalki, Karina Sadlaoud, Julie Lerond, Hélène Bras, Patrice Coulon, Jean-Michel Brezun, Jacques-Olivier Coq, Laurent Vinay

Publikováno v: Experimental Neurology
Experimental Neurology, 2018, 299, pp.1-14. ⟨10.1016/j.expneurol.2017.09.002⟩
Experimental Neurology, Elsevier, 2018, 299, pp.1-14. ⟨10.1016/j.expneurol.2017.09.002⟩

International audience; Rats with complete spinal cord transection (SCT) can recover hindlimb locomotor function under strategies combining exercise training and 5-HT agonist treatment. This recovery is expected to result from structural and function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307cfe5a84198b950b53a649cb2796f3
https://doi.org/10.1016/j.expneurol.2017.09.002

Prochlorperazine Increases KCC2 Function and Reduces Spasticity after Spinal Cord Injury

Autor: Irene Sanchez Brualla, Laurent Vinay, Philippe Marino, Frédéric Brocard, Florian Gackière, Renzo Mancuso, Laetitia Stuhl-Gourmand, Sylvie Liabeuf

Publikováno v: Journal of Neurotrauma
Journal of Neurotrauma, Mary Ann Liebert, 2017, 34 (24), pp.3397-3406. ⟨10.1089/neu.2017.5152⟩
Journal of Neurotrauma, Mary Ann Liebert, 2017, ⟨10.1089/neu.2017.5152⟩
Journal of neurotrauma
Journal of Neurotrauma, 2017, ⟨10.1089/neu.2017.5152⟩

International audience; In mature neurons, low intracellular chloride level required for inhibition is maintained by the potassium-chloride cotransporter, KCC2. Impairment of Cl-extrusion after KCC2 dysfunction has been involved in many central nervo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb44014ac617d33377249ba13b9af2e
https://hal-amu.archives-ouvertes.fr/hal-01791133