Výsledky vyhledávání - "Laurent Thion"

Host cell protein testing strategy for hepatitis B antigen in Hexavalent vaccine – Towards a general testing strategy for recombinant vaccines

Autor: Laurent Thion, Audrey Toinon, Beata Gajewska, Sylvie Uhlrich, Nolwenn Nougarede, Christelle Fontaine, Bruce Carpick

Publikováno v: Biologicals. 54:1-7

Background Recombinant proteins expressed in host cell systems may contain host cell proteins (HCP) as impurities. While there is no clear evidence of clinical adverse events attributable to HCP, HCP levels and profiles must be documented to meet reg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a9634f1254eae22cb7ce1fa8086364
https://doi.org/10.1016/j.biologicals.2018.05.006

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Preliminary characterisation of the blue-green pigment 'marennine' from the marine tychopelagic diatom Haslea ostrearia (Gaillon/Bory) Simonsen

Autor: Franck Zal, Pierre Pondaven, Laurent Thion, Joël Fleurence, Philippe Rosa, Blanche Cahingt, Michèle Morançais, Fabrice Fleury, Jean-Bernard Pouvreau

Publikováno v: Journal of Applied Phycology
Journal of Applied Phycology, Springer Verlag, 2006, 18 (6), pp.757-767

International audience; Haslea ostrearia is a common marine tychopelagic diatom which has the particularity of synthesizing a blue-green hydrosoluble pigment called “marennine”. This pigment, when released into the external medium, is known to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c690a8183ea03cdfd86e89ce987a82
https://doi.org/10.1007/s10811-006-9087-x

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Lithostathine Quadruple-helical Filaments Form Proteinase K-resistant Deposits in Creutzfeldt-Jakob Disease

Autor: Bernard Michel, Erich E. Wanker, Sabine Engemann, Stéphane Marchal, Monique Erard, Bernard Monsarrat, Michel Mohr, Marcus Fändrich, Laurent Thion, Emmanuelle Laurine, Christopher M. Dobson, Catherine Gregoire, Jean-Michel Verdier

Publikováno v: Journal of Biological Chemistry. 278:51770-51778

Autocatalytic cleavage of lithostathine leads to the formation of quadruple-helical fibrils (QHF-litho) that are present in Alzheimer's disease. Here we show that such fibrils also occur in Creutzfeldt-Jakob and Gerstmann-Sträussler-Scheinker diseas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bedfddcfce8c8009299b8d79dc74d90
https://doi.org/10.1074/jbc.m306767200

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Investigating the endonuclease activity of four Pyrococcus abyssi inteins

Autor: Cécile Morlot, Jean-Luc Rolland, Jacques Dietrich, Isabelle Saves, Jean-Michel Masson, Laurent Thion

Publikováno v: Nucleic Acids Research. 30:4158-4165

Among the 14 inteins of the Pyrococcus abyssi genome, 10 harbour the LAGLIDADG motifs of dodecapeptide endonucleases. Four of these were cloned, expressed in Escherichia coli and purified to assay their potential endonuclease activity. PabRIR1-2 and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fd8638ecf703b1f2b92a593e3a5e460
https://doi.org/10.1093/nar/gkf556

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Role of the ATP-binding site of SopA protein in partition of the F plasmid 1 1Edited by M. Yaniv

Autor: Virginie Libante, David Lane, Laurent Thion

Publikováno v: Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2001, 314 (3), pp.387-399. ⟨10.1006/jmbi.2001.5158⟩

International audience; SopA belongs to a large family of bacterial partition protein ATPases. It helps stabilize the F plasmid by acting as the primary repressor of transcription of the sopAB operon, preventing the destabilizing effects of Sop prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2a347b688f84b13de9b0e9c77be8839
https://doi.org/10.1006/jmbi.2001.5158

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Identification of the Enzymatic Active Site of Tobacco Caffeoyl-coenzyme A O-Methyltransferase by Site-directed Mutagenesis

Autor: Michel Legrand, Marc Bergdoll, Laurent Hoffmann, Monique Erard, Laurent Thion, Stéphane Maury

Publikováno v: Journal of Biological Chemistry. 276:36831-36838

Animal catechol O-methyltransferases and plant caffeoyl-coenzyme A O-methyltransferases share about 20% sequence identity and display common structural features. The crystallographic structure of rat liver catechol O-methyltransferase was used as a t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3582dbca7c16d1b3a0c4b79f43d1a85f
https://doi.org/10.1074/jbc.m104977200

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Two novel phycoerythrin-associated linker proteins in the marine cyanobacterium Synechococcus sp. strain WH8102

Autor: Laurent Thion, Frédéric Partensky, Jean-Claude Thomas, Yves Lemoine, Christophe Six, Frank Zal

Publikováno v: Journal of Bacteriology
Journal of Bacteriology, 2005, 187 (5), pp.1685-1694. ⟨10.1128/JB.187.5.1685-1694.2005⟩

The recent availability of the whole genome ofSynechococcussp. strain WH8102 allows us to have a global view of the complex structure of the phycobilisomes of this marine picocyanobacterium. Genomic analyses revealed several new characteristics of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab02f7cba673d13e9eccf4ea3795556b
https://pubmed.ncbi.nlm.nih.gov/15716439

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The endo-beta-agarases AgaA and AgaB from the marine bacterium Zobellia galactanivorans: two paralogue enzymes with different molecular organizations and catalytic behaviours

Autor: Mirjam Czjzek, Didier Flament, Bernard Kloareg, Philippe Potin, William Helbert, Tristan Barbeyron, Julie Allouch, Gurvan Michel, Laurent Thion, Murielle Jam

Publikováno v: The Biochemical journal. 385(Pt 3)

Two β-agarase genes, agaA and agaB, were functionally cloned from the marine bacterium Zobellia galactanivorans. The agaA and agaB genes encode proteins of 539 and 353 amino acids respectively, with theoretical masses of 60 and 40 kDa. These two β-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd15e4e68a23934e1d18233b7f185368
https://pubmed.ncbi.nlm.nih.gov/15456406

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Structure/function relationships within the RNA recognition motif family applied to the hermes gene product

Autor: Laurent Thion, Monique Erard

Publikováno v: Protein and peptide letters. 9(2)

The RNA Recognition Motif (RRM) family of RNA-binding domains comprises distinct structural subclasses which can be equated to various types of cognate RNA(s) in relation to biological functions. By identifying structural templates within the appropr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda7716814467deaaf2c30f0e31239c5
https://pubmed.ncbi.nlm.nih.gov/12141909

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