Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Laurent Taupenot"'
Autor:
Steven J Bark, Jill Wegrzyn, Laurent Taupenot, Michael Ziegler, Daniel T O'Connor, Qi Ma, Michael Smoot, Trey Ideker, Vivian Hook
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e41134 (2012)
Secretory vesicles are required for release of chemical messengers to mediate intercellular signaling among human biological systems. It is necessary to define the organization of the protein architecture of the 'human' dense core secretory vesicles
Externí odkaz:
https://doaj.org/article/748397bcb31240c899b31eda9fee1fe3
Autor:
Laurent Taupenot, Zhiyun Wei, Kuixing Zhang, C. Makena Hightower, Jose Pablo Miramontes-Gonzalez, Caroline M. Nievergelt, Nilima Biswas, Michael G. Ziegler, Nina Elkelis, Andrew J. Schork, Manjula Mahata, Mats Stridsberg, Fangwen Rao, Daniel T. O'Connor
Publikováno v:
Journal of Neurochemistry. 127:750-761
The Syrian Cardiomyopathic Hamster (BIO-14.6/53.58 strains) model of cardiac failure, resulting from naturally occurring deletion at the SGCD (delta-sarcoglycan) locus, displays widespread disturbances in catecholamine metabolism. Rare Mendelian myop
Autor:
Daniel T. O'Connor, Thomas Reinheckel, Laurent Taupenot, Lydiane Funkelstein, W. Douglas Lu, Christoph Peters, Britta Koch, Thomas Toneff, Charles Mosier, Vivian Hook
Publikováno v:
Journal of Biological Chemistry. 287:15232-15241
Proteases are required for processing precursors into active neuropeptides that function as neurotransmitters for cell-cell communication. This study demonstrates the novel function of human cathepsin V protease for producing the neuropeptides enkeph
Autor:
Nitin Gupta, Pavel A. Pevzner, Laurent Taupenot, Steven J. Bark, Vivian Hook, Weiya D. Lu, Daniel T. O'Connor
Publikováno v:
Journal of Proteome Research. 9:5065-5075
Neuropeptides are required for cell-cell communication for the regulation of physiological and pathological processes. While selected neuropeptides of known biological activities have been studied, global analyses of the endogenous profile of human p
Autor:
Bhawanjit K. Brar, Juan L. Rodriguez-Flores, Fangwen Rao, Daniel T. O'Connor, Kuixing Zhang, Lian Zhang, Laurent Taupenot
Publikováno v:
Circulation: Cardiovascular Genetics. 3:187-198
Background— Tyrosine hydroxylase ( TH ) is the rate-limiting enzyme in catecholamine biosynthesis. Common genetic variation at the human TH promoter predicts alterations in autonomic activity and blood pressure, but how such variation influences hu
Autor:
Juan L. Rodriguez-Flores, Jill Waalen, Bamidele O. Tayo, Rany M. Salem, Maple M. Fung, Fangwen Rao, Brinda K. Rana, Daniel T. O'Connor, Kuixing Zhang, Lei Wang, Sushil K. Mahata, Sajalendu Ghosh, Manjula Mahata, Laurent Taupenot
Publikováno v:
Journal of the American College of Cardiology. 55:1463-1475
ObjectivesThe purpose of this study is to understand whether naturally occurring genetic variation in the promoter of chromogranin B (CHGB), a major constituent of catecholamine storage vesicles, is functional and confers risk for cardiovascular dise
Autor:
Douglas W. Smith, Nicholas J. Schork, Jennifer Wessel, Sushil K. Mahata, Anne Marie Valle, Jeannine Haeller, Michael G. Ziegler, Todd T. Talley, Daniel T. O'Connor, Palmer Taylor, Jiaur R. Gayen, Eleazar Eskin, Laurent Taupenot, Fangwen Rao, Vafa Mahboubi, Brinda K. Rana, Mats Stridsberg, Madhusudan Das
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 331:419-428
Nicotinic acetylcholine receptors (nAChRs) are combinations of subunits arranged as pentamers encircling a central cation channel. At least nine alpha and four beta subunits are expressed in the central and peripheral nervous systems; their presence
Autor:
Sucheta M. Vaingankar, Daniel T. O'Connor, Maïté Courel, Nilima Biswas, Juan L. Rodriguez-Flores, Sushil K. Mahata, Justin W. Torpey, Manjula Mahata, Laurent Taupenot, Jiaur R. Gayen
Publikováno v:
Endocrinology. 150:3547-3557
Chromogranin A (CgA), the major soluble protein in chromaffin granules, is proteolytically processed to generate biologically active peptides including the catecholamine release inhibitory peptide catestatin. Here we sought to determine whether cyste
Autor:
Hansruedi Stettler, Martin Spiess, Bérengère Fayard, Cristina Prescianotto-Baschong, Nicole Beuret, Laurent Taupenot
Publikováno v:
Biochemical Journal. 418:81-91
In endocrine cells, prohormones and granins are segregated in the TGN (trans-Golgi network) from constitutively secreted proteins, stored in concentrated form in dense-core secretory granules, and released in a regulated manner on specific stimulatio
Autor:
Brian P. Kennedy, Brinda K. Rana, Gen Wen, Sushil K. Mahata, Nicholas J. Schork, Michael G. Ziegler, Jennifer Wessel, Laurent Taupenot, Juan L. Rodriguez-Flores, Douglas W. Smith, Fangwen Rao, Daniel T. O'Connor, Lian Zhang, Madhusudan Das, Peter E. Cadman, Kuixing Zhang, Rany M. Salem
Publikováno v:
Annals of the New York Academy of Sciences. 1148:282-296
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. Does common genetic variation at human TH alter autonomic activity and predispose to cardiovascular disease? We undertook systematic polymorphism discovery at the TH