Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Laurent Seugnet"'
Autor:
Céline Petitgas, Laurent Seugnet, Amina Dulac, Giorgio Matassi, Ali Mteyrek, Rebecca Fima, Marion Strehaiano, Joana Dagorret, Baya Chérif-Zahar, Sandrine Marie, Irène Ceballos-Picot, Serge Birman
Publikováno v:
eLife, Vol 12 (2024)
Adenine phosphoribosyltransferase (APRT) and hypoxanthine-guanine phosphoribosyltransferase (HGPRT) are two structurally related enzymes involved in purine recycling in humans. Inherited mutations that suppress HGPRT activity are associated with Lesc
Externí odkaz:
https://doaj.org/article/a6c4700cc47642c5b46c1c2efc74abf6
Autor:
Hui Li, Laurent Seugnet
Publikováno v:
Neural Regeneration Research, Vol 20, Iss 5, Pp 1350-1363 (2025)
The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and, either directly or indirectly, overall body health, encompassing metabolic and cardiovascular well-being. Given the heightened metabolic activi
Externí odkaz:
https://doaj.org/article/787039de726b4045882cde46a0f1a7a2
Autor:
Hui Li, Sami Aboudhiaf, Sandrine Parrot, Céline Scote-Blachon, Claire Benetollo, Jian-Sheng Lin, Laurent Seugnet
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113025- (2023)
Summary: The Pallidin protein is a central subunit of a multimeric complex called biogenesis of lysosome-related organelles complex 1 (BLOC1) that regulates specific endosomal functions and has been linked to schizophrenia. We show here that downregu
Externí odkaz:
https://doaj.org/article/19c043bc0e23499e8875ebba91414881
Autor:
Marine Thieux, Aurore Guyon, Vania Herbillon, Lydie Merle, Jean-Philippe Lachaux, Sabine Plancoulaine, Laurent Seugnet, Patricia Franco
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
ObjectivesSleepiness is associated with decreased cognitive abilities and remains one of the main causes of fatal road accidents. The tools currently available to assess sleepiness, such as questionnaires, are subject to intra- and inter-individual v
Externí odkaz:
https://doaj.org/article/a95f1270d5c54153a3b2cbdb41eee1ba
Publikováno v:
Frontiers in Neural Circuits, Vol 11 (2017)
Although patients with primary insomnia experience sleep disruption, they are able to maintain normal performance on a variety of cognitive tasks. This observation suggests that insomnia may be a condition where predisposing factors simultaneously in
Externí odkaz:
https://doaj.org/article/455ee4ccf153432991daa89e0615c248
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006507 (2017)
Circadian clocks control many self-sustained rhythms in physiology and behavior with approximately 24-hour periodicity. In many organisms, oxidative stress and aging negatively impact the circadian system and sleep. Conversely, loss of the clock decr
Externí odkaz:
https://doaj.org/article/074006092cc343e5b596ad108cb1935a
Publikováno v:
PLoS Biology, Vol 8, Iss 8 (2010)
Extended periods of waking result in physiological impairments in humans, rats, and flies. Sleep homeostasis, the increase in sleep observed following sleep loss, is believed to counter the negative effects of prolonged waking by restoring vital biol
Externí odkaz:
https://doaj.org/article/27a7a23ded6d4ce7bee48b23fd957d68
Autor:
Laurent Seugnet, Christelle Anaclet, Magali Perier, Jean-François Ghersi-Egea, Jian-Sheng Lin
Publikováno v:
CNS Neuroscience & Therapeutics. 29:483-486
Histamine (HA) and orexin (Ox, or hypocretin) neurons act distinctly and synergistically in wake control. A double knock out mouse genotype lacking both HA and Ox shows all sleep disorders of human narcolepsy. We identified in this mouse brain a shar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc8f79d01fb2d4d3e6180287e91f3b07
https://doi.org/10.1111/cns.13995
https://doi.org/10.1111/cns.13995
Autor:
Hui Li, Sami Aboudhiaf, Sandrine Parrot, Céline Scote-Blachon, Claire Benetollo, Jian-Sheng Lin, Laurent Seugnet
The Pallidin protein is a component of a multimeric complex named the Biogenesis of Lysosome-related Organelles Complex 1 (BLOC1) that regulates specific endosomal function and transmembrane protein trafficking in many different cell types. In the br
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b4f9b3c8d3282f40380353c508d4bca
https://doi.org/10.1101/2022.05.03.490434
https://doi.org/10.1101/2022.05.03.490434
Autor:
Sabine Plancoulaine, Jian-Sheng Lin, Patricia Franco, Marine Thieux, Vania Herbillon, Agathe Marcastel, Min Zhang, Anne Guignard-Perret, Aurore Guyon, Laurent Seugnet
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 4075, p 4075 (2020)
Journal of Clinical Medicine
Journal of Clinical Medicine, MDPI, 2020, 9 (12), pp.4075. ⟨10.3390/jcm9124075⟩
Journal of Clinical Medicine, 2020, 9 (12), pp.4075. ⟨10.3390/jcm9124075⟩
Volume 9
Issue 12
Journal of Clinical Medicine
Journal of Clinical Medicine, MDPI, 2020, 9 (12), pp.4075. ⟨10.3390/jcm9124075⟩
Journal of Clinical Medicine, 2020, 9 (12), pp.4075. ⟨10.3390/jcm9124075⟩
Volume 9
Issue 12
High cognitive functioning could be a protective factor for school difficulties, behavioral and mood impairments in children with narcolepsy. To investigate this factor, we studied the intellectual abilities of 74 children with narcolepsy (43 boys, 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d190e48f919348c925c0038444e9545
https://www.mdpi.com/2077-0383/9/12/4075
https://www.mdpi.com/2077-0383/9/12/4075