Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Laurent Pradier"'
Autor:
Zemin Wang, Ming Jin, Wei Hong, Wen Liu, David Reczek, Valentina N. Lagomarsino, Yuan Hu, Tim Weeden, Matthew P. Frosch, Tracy L. Young-Pearse, Laurent Pradier, Dennis Selkoe, Dominic M. Walsh
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-20 (2023)
Abstract Despite ongoing debate, the amyloid β-protein (Aβ) remains the prime therapeutic target for the treatment of Alzheimer’s disease (AD). However, rational drug design has been hampered by a lack of knowledge about neuroactive Aβ. To help
Externí odkaz:
https://doaj.org/article/a44ed862eab649ab94c4fe38529e56d1
Autor:
Claire Hawksworth, Fatima Salih, Katharine Cresswell, Lennert Steukers, Carlos Diaz, Lewis Killin, Laurent Pradier, Angela Bradshaw, Dalia Dawoud
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
The European Commission's Innovative Medicines Initiative (IMI) has funded many projects focusing on neurodegenerative disorders (ND) that aimed to improve the diagnosis, prevention, treatment and understanding of NDs. To facilitate collaboration acr
Externí odkaz:
https://doaj.org/article/324888d23cb64b639698dcdb7b88bd0f
Autor:
Diana O'Rourke, Nina Coll-Padrós, Angela Bradshaw, Lewis Killin, Laurent Pradier, Jean Georges, Dalia M. Dawoud, Lennert Steukers, Carlos Diaz
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The IMI public-private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA) was launched in 2008 with an initial budget of €2 billion. Aiming to accelerate the development of
Externí odkaz:
https://doaj.org/article/1b7a834d77e34a288159e0877b555c1c
Reporter cell assay for human CD33 validated by specific antibodies and human iPSC-derived microglia
Autor:
Jannis Wißfeld, Mona Mathews, Omar Mossad, Paola Picardi, Alessandro Cinti, Loredana Redaelli, Laurent Pradier, Oliver Brüstle, Harald Neumann
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract CD33/Sialic acid-binding Ig-like lectin 3 (SIGLEC3) is an innate immune receptor expressed on myeloid cells and mediates inhibitory signaling via tyrosine phosphatases. Variants of CD33 are associated with Alzheimer’s disease (AD) suggesti
Externí odkaz:
https://doaj.org/article/19d23649beca49f89cee8a4250b51988
Autor:
Tuan-Minh Do, Cécile Capdevila, Laurent Pradier, Véronique Blanchard, Mati Lopez-Grancha, Nathalie Schussler, Anke Steinmetz, Jochen Beninga, Denis Boulay, Philippe Dugay, Patrick Verdier, Nadine Aubin, Gihad Dargazanli, Catarina Chaves, Elisabeth Genet, Yves Lossouarn, Christophe Loux, François Michoux, Nicolas Moindrot, Franck Chanut, Thierry Gury, Stéphanie Eyquem, Delphine Valente, Olivier Bergis, Ercole Rao, Dominique Lesuisse
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 58-77 (2020)
Most antibodies display very low brain exposure due to the blood-brain barrier (BBB) preventing their entry into brain parenchyma. Transferrin receptor (TfR) has been used previously to ferry antibodies to the brain by using different formats of bisp
Externí odkaz:
https://doaj.org/article/83381acf39a84e849321af0a96b558c0
Autor:
Laurent Pradier, Véronique Blanchard-Brégeon, Andrees Bohme, Thomas Debeir, Jean Menager, Patrick Benoit, Pascal Barneoud, Véronique Taupin, Philippe Bertrand, Philippe Dugay, Béatrice Cameron, Yi Shi, Souad Naimi, Marc Duchesne, Marie Gagnaire, Tim Weeden, Tara Travaline, David Reczek, Leonard Khiroug, Mohamed Slaoui, Pascale Brunel, Hidehiro Fukuyama, Jeffrey Ravetch, Thierry Canton, Caroline Cohen
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-23 (2018)
Abstract Background Anti-amyloid β (Aβ) immunotherapy represents a major area of drug development for Alzheimer’s disease (AD). However, Aβ peptide adopts multiple conformations and the pathological forms to be specifically targeted have not bee
Externí odkaz:
https://doaj.org/article/8e1251be3bb94110879a8c1cd6a6d727
Autor:
Anthony Brureau, Véronique Blanchard-Bregeon, Catherine Pech, Stéphanie Hamon, Pascal Chaillou, Jean-Claude Guillemot, Pascal Barneoud, Philippe Bertrand, Laurent Pradier, Thomas Rooney, Nathalie Schussler
Publikováno v:
Neurobiology of Disease, Vol 104, Iss , Pp 73-84 (2017)
Accumulation of neurofilaments (NFs), the major constituents of the neuronal cytoskeleton, is a distinctive feature of neurological diseases and several studies have shown that soluble NFs can be detected in the cerebrospinal fluid (CSF) of patients
Externí odkaz:
https://doaj.org/article/67c0aa37b5994dcea00b57f71209cffa
Autor:
Bradford M Elmer, Kurt A Swanson, Dinesh S Bangari, Peter A Piepenhagen, Errin Roberts, Tatyana Taksir, Lei Guo, Maria-Carmen Obinu, Pascal Barneoud, Susan Ryan, Bailin Zhang, Laurent Pradier, Zhi-Yong Yang, Gary J Nabel
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0226245 (2019)
Antibody therapies for Alzheimer's Disease (AD) hold promise but have been limited by the inability of these proteins to migrate efficiently across the blood brain barrier (BBB). Central nervous system (CNS) gene transfer by vectors like adeno-associ
Externí odkaz:
https://doaj.org/article/d3951a84b17a4191bede4dca1cb53655
Autor:
Corinne Mbebi, Jose-Luis González de Aguilar, Violaine Sée, Luc Dupuis, Nelly Frossard, Luc Mercken, Laurent Pradier, Yves Larmet, Jean-Philippe Loeffler
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 129-141 (2005)
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by the accumulation of extracellular depositions of fibrillar β-amyloid (Aβ), which is derived from the alternative processing of β-amyloid precursor protein (APP)
Externí odkaz:
https://doaj.org/article/c50519f4e70747238489ec2ecb4593e3
Autor:
Katrin Schuessel, Stephanie Schäfer, Thomas A. Bayer, Christian Czech, Laurent Pradier, Franz Müller-Spahn, Walter E. Müller, Anne Eckert
Publikováno v:
Neurobiology of Disease, Vol 18, Iss 1, Pp 89-99 (2005)
Oxidative stress plays an important role in the pathogenesis of Alzheimer's disease. To determine which mechanisms cause the origin of oxidative damage, we analyzed enzymatic antioxidant defense (Cu/Zn-superoxide dismutase Cu/Zn-SOD, glutathione pero
Externí odkaz:
https://doaj.org/article/3fe3eeba90e64e07a67edced5036a3ca