Výsledky vyhledávání - "Laurent Modolo"

Akademický článek

Differentiation is accompanied by a progressive loss in transcriptional memory

Autor: Camille Fourneaux, Laëtitia Racine, Catherine Koering, Sébastien Dussurgey, Elodie Vallin, Alice Moussy, Romuald Parmentier, Fanny Brunard, Daniel Stockholm, Laurent Modolo, Franck Picard, Olivier Gandrillon, Andras Paldi, Sandrine Gonin-Giraud

Publikováno v: BMC Biology, Vol 22, Iss 1, Pp 1-20 (2024)

Abstract Background Cell differentiation requires the integration of two opposite processes, a stabilizing cellular memory, especially at the transcriptional scale, and a burst of gene expression variability which follows the differentiation inductio

Externí odkaz: https://doaj.org/article/29a9a65391ea4083ac4d52516b373d50

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Akademický článek

Condensin positioning at telomeres by shelterin proteins drives sister-telomere disjunction in anaphase

Autor: Léonard Colin, Celine Reyes, Julien Berthezene, Laetitia Maestroni, Laurent Modolo, Esther Toselli, Nicolas Chanard, Stephane Schaak, Olivier Cuvier, Yannick Gachet, Stephane Coulon, Pascal Bernard, Sylvie Tournier

Publikováno v: eLife, Vol 12 (2023)

The localization of condensin along chromosomes is crucial for their accurate segregation in anaphase. Condensin is enriched at telomeres but how and for what purpose had remained elusive. Here, we show that fission yeast condensin accumulates at tel

Externí odkaz: https://doaj.org/article/ae1632c8ec9d4cbe92ca22befe09a455

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Akademický článek

Evidence for close molecular proximity between reverting and undifferentiated cells

Autor: Souad Zreika, Camille Fourneaux, Elodie Vallin, Laurent Modolo, Rémi Seraphin, Alice Moussy, Elias Ventre, Matteo Bouvier, Anthony Ozier-Lafontaine, Arnaud Bonnaffoux, Franck Picard, Olivier Gandrillon, Sandrine Gonin-Giraud

Publikováno v: BMC Biology, Vol 20, Iss 1, Pp 1-16 (2022)

Abstract Background According to Waddington’s epigenetic landscape concept, the differentiation process can be illustrated by a cell akin to a ball rolling down from the top of a hill (proliferation state) and crossing furrows before stopping in ba

Externí odkaz: https://doaj.org/article/c2d10c001e0f4d87920f7ade838d64ab

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Akademický článek

Characterizing the interplay between gene nucleotide composition bias and splicing

Autor: Sébastien Lemaire, Nicolas Fontrodona, Fabien Aubé, Jean-Baptiste Claude, Hélène Polvèche, Laurent Modolo, Cyril F. Bourgeois, Franck Mortreux, Didier Auboeuf

Publikováno v: Genome Biology, Vol 20, Iss 1, Pp 1-21 (2019)

Abstract Background Nucleotide composition bias plays an important role in the 1D and 3D organization of the human genome. Here, we investigate the potential interplay between nucleotide composition bias and the regulation of exon recognition during

Externí odkaz: https://doaj.org/article/5a5d20b3977c4af3acdd667e1f6ebabc

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Akademický článek

Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

Autor: Clémence Hocquet, Xavier Robellet, Laurent Modolo, Xi-Ming Sun, Claire Burny, Sara Cuylen-Haering, Esther Toselli, Sandra Clauder-Münster, Lars Steinmetz, Christian H Haering, Samuel Marguerat, Pascal Bernard

Publikováno v: eLife, Vol 7 (2018)

Condensins are genome organisers that shape chromosomes and promote their accurate transmission. Several studies have also implicated condensins in gene expression, although any mechanisms have remained enigmatic. Here, we report on the role of conde

Externí odkaz: https://doaj.org/article/9d76ef2a02bb47c2ac8a6b183647ac2e

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L’infrastructure-frontière comme catalyseur de la mise en place d’un système de pilotage du développement durable au sein des collectivités territoriales ? L’exemple de la communauté de communes des Crêtes Pré-Ardennaises

Autor: Laurent Modolo, Thierry Côme, Jean-Luc Petitjean

Publikováno v: revue GMP Gestion et Management public
revue GMP Gestion et Management public, 2021, Volume 8 / n° 3 (3), pp.11-46. ⟨10.3917/gmp.083.0011⟩
Gestion et management public [2012-...]
Gestion et management public [2012-..], AIRMAP, 2021, Volume 8 / n° 3 (3), pp.11-46. ⟨10.3917/gmp.083.0011⟩

Les collectivites territoriales jouent un role essentiel dans la mise en œuvre du developpement durable local. Toutefois, on percoit encore mal les modalites de cette mise en œuvre. L’objectif de cet article est de proposer une analyse de la mise

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71742cc8fec9a847e144ecb92c57bf31
https://doi.org/10.3917/gmp.083.0011

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Differentiation is accompanied by a progressive loss in transcriptional memory

Cell differentiation requires the integration of two opposite processes, a stabilizing cellular memory, especially at the transcriptional scale, and a burst of gene expression variability which follows the differentiation induction. Therefore, the ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::caf2ec8c4276d370092f8fc7e3d018ec
https://doi.org/10.1101/2022.11.02.514828

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RNA helicase-dependent gene looping impacts messenger RNA processing

Autor: Sophie Terrone, Jessica Valat, Nicolas Fontrodona, Guillaume Giraud, Jean-Baptiste Claude, Emmanuel Combe, Audrey Lapendry, Hélène Polvèche, Lamya Ben Ameur, Arnaud Duvermy, Laurent Modolo, Pascal Bernard, Franck Mortreux, Didier Auboeuf, Cyril F Bourgeois

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (16), pp.9226-9246. ⟨10.1093/nar/gkac717⟩

DDX5 and DDX17 are DEAD-box RNA helicase paralogs which regulate several aspects of gene expression, especially transcription and splicing, through incompletely understood mechanisms. A transcriptome analysis of DDX5/DDX17-depleted human cells confir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d1d6a01a835a5b2b2e253351d58ad00
https://hal.science/hal-03842696

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Condensin positioning at telomeres by Taz1 promotes telomere disjunction in anaphase

Autor: Léonard Colin, Céline Reyes, Julien Berthezene, Laetitia Maestroni, Laurent Modolo, Esther Toselli, Nicolas Chanard, Stephane Schaak, Olivier Cuvier, Yannick Gachet, Stéphane Coulon, Pascal Bernard, Sylvie Tournier

The localization of condensin along chromosome arms is crucial for chromosome segregation in anaphase. Condensin is also enriched at telomeres but how and for what function remains elusive. Here we show that Taz1, the main component of the Shelterin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f157179344fcc4af4d75a822a74797
https://doi.org/10.1101/2022.03.18.484892

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Divergent clonal differentiation trajectories establish CD8+ memory T cell heterogeneity during acute viral infections in humans

Publikováno v: Cell Reports
Cell Reports, 2021, 35 (8), pp.109174. ⟨10.1016/j.celrep.2021.109174⟩
Cell Reports, Elsevier Inc, 2021, 35 (8), pp.109174. ⟨10.1016/j.celrep.2021.109174⟩

International audience; The CD8+ T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogeneous repertoire of effector and memory cells. How individual T cell clones contribute to this h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb8ce57030c63c4ec889d3a7af7a04e
https://hal.science/hal-03345357

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