How Nanoparticles Modify Adsorbed Proteins: Impact of Silica Nanoparticles on the Hemoglobin Active Site

Autor: Gaël Giraudon--Colas, Stéphanie Devineau, Laurent Marichal, Elodie Barruet, Andrea Zitolo, Jean-Philippe Renault, Serge Pin

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 4, p 3659 (2023)

The adsorption of proteins on surfaces has been studied for a long time, but the relationship between the structural and functional properties of the adsorbed protein and the adsorption mechanism remains unclear. Using hemoglobin adsorbed on silica n

Externí odkaz: https://doaj.org/article/ae23656c018d404d85b4abee3f705b10

Human Serum Albumin in the Presence of AGuIX Nanoagents: Structure Stabilisation without Direct Interaction

Autor: Xiaomin Yang, Marta Bolsa-Ferruz, Laurent Marichal, Erika Porcel, Daniela Salado-Leza, François Lux, Olivier Tillement, Jean-Philippe Renault, Serge Pin, Frank Wien, Sandrine Lacombe

Publikováno v: International Journal of Molecular Sciences, Vol 21, Iss 13, p 4673 (2020)

The gadolinium-based nanoagent named AGuIX® is a unique radiosensitizer and contrast agent which improves the performance of radiotherapy and medical imaging. Currently tested in clinical trials, AGuIX® is administrated to patients via intravenous

Externí odkaz: https://doaj.org/article/efaa99adc85e4da0b63ba4fe6d09e808

Protein–Nanoparticle Interactions: What Are the Protein–Corona Thickness and Organization?

Autor: Jean Philippe Renault, Jean-Christophe Aude, Serge Pin, Jean Labarre, Gaël Giraudon--Colas, Laurent Marichal, Antoine Thill, Fabrice Cousin, Yves Boulard

Publikováno v: Langmuir
Langmuir, American Chemical Society, 2019, 35 (33), pp.10831-10837. ⟨10.1021/acs.langmuir.9b01373⟩
Langmuir, 2019, 35 (33), pp.10831-10837. ⟨10.1021/acs.langmuir.9b01373⟩

International audience; Protein adsorption on a surface is generally evaluated in terms of the evolution of the proteins’ structures and functions. However, when the surface is that of a nanoparticle, the protein corona formed around it possesses a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d370c1bf2a3bb62af7f161a2057205
https://doi.org/10.1021/acs.langmuir.9b01373

Relationships between RNA Topology and Nucleocapsid Structure in a Model Icosahedral Virus

Autor: Kalouna Kra, Yinan Dong, Stéphane Bressanelli, Roya Zandi, Guillaume Tresset, Laurent Marichal, Sanaz Panahandeh, Laetitia Gargowitsch, Christina Sizun, Rafael Leite Rubim

Publikováno v: Biophysical Journal
Biophysical Journal, 2021, 120 (18), pp.3925-3936. ⟨10.1016/j.bpj.2021.08.021⟩
Biophysical Society Annual Meeting
Biophysical Society Annual Meeting, Feb 2022, San Francisco, United States. pp.330a-331a, ⟨10.1016/j.bpj.2021.11.1107⟩
Web of Science
Biophys J
Biophysical Journal, Biophysical Society, 2021, 120 (18), pp.3925-3936. ⟨10.1016/j.bpj.2021.08.021⟩

International audience; The process of genome packaging in most of viruses is poorly understood, notably the role of the genome itself in the nucleocapsid structure. For simple icosahedral single-stranded RNA viruses, the branched topology due to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5ba07c43e77d4f98e5824deabff838
https://hal.science/hal-03351285/document

Albumin-driven disassembly of lipidic nanoparticles: the specific case of the squalene-adenosine nanodrug

Autor: Marie Rouquette, Frédéric Gobeaux, Fabienne Testard, Semen O Yesylevsky, Didier Desmaële, Jean Philippe Renault, Joëlle Bizeau, Christophe Ramseyer, Frank Wien, Laurent Marichal, Isabelle Grillo, Sinda Lepetre-Mouelhi, Patrick Guenoun, Patrick Couvreur, Firmin Samson

Publikováno v: Nanoscale
Nanoscale, 2020, 12, pp.2793-2809. ⟨10.1039/C9NR06485K⟩
Nanoscale, Royal Society of Chemistry, 2020, 12, pp.2793-2809. ⟨10.1039/C9NR06485K⟩
Nanoscale, Royal Society of Chemistry, 2020, 12 (4), pp.2793-2809. ⟨10.1039/c9nr06485k⟩

International audience; In the field of nanomedicine, nanostructured nanoparticles (NPs) made of self-assembling prodrugs emerged in the recent years with promising properties. In particular, squalene-based drug nanoparticles have already shown their

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc3652b80f8b43ffafd7f7bc4c4ce26
https://cea.hal.science/cea-02434394/document