Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Laurent Mackay"'
Autor:
Laurent MacKay, Anmar Khadra
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 18, Iss , Pp 393-416 (2020)
The forces actively generated by motile cells must be transmitted to their environment in a spatiotemporally regulated manner, in order to produce directional cellular motion. This task is accomplished through integrin-based adhesions, large macromol
Externí odkaz:
https://doaj.org/article/4ca8d71ad1ef4326887f09c4cba8aa6b
Autor:
Jessica K. Lyda, Zhang L. Tan, Abira Rajah, Asheesh Momi, Laurent Mackay, Claire M. Brown, Anmar Khadra
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 17, Iss , Pp 1436-1452 (2019)
Cell migration is a tightly-regulated process that involves protein gradients formed by the Rho family of GTPases, including Rho and Rac. The front (rear) of cells is generally characterized by higher active Rac (Rho) and lower active Rho (Rac) conce
Externí odkaz:
https://doaj.org/article/0a5cce6a08d44c608e2aa0ee5d9d412e
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 7, p e1005643 (2017)
The P2X4 receptor (P2X4R) is a member of a family of purinergic channels activated by extracellular ATP through three orthosteric binding sites and allosterically regulated by ivermectin (IVM), a broad-spectrum antiparasitic agent. Treatment with IVM
Externí odkaz:
https://doaj.org/article/0311971a97b240bb8329befcaa5cce3b
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Dynamic processes, such as intracellular calcium signaling, are hallmark of cellular biology. As real-time imaging modalities become widespread, a need for analytical tools to reliably characterize time-series data without prior knowledge of the natu
Externí odkaz:
https://doaj.org/article/fe61428f70384bea855d4281b84063b9
Autor:
Asheesh Momi, Laurent MacKay, Claire M. Brown, Zhang L. Tan, Anmar Khadra, Jessica K. Lyda, Abira Rajah
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1436-1452 (2019)
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 1436-1452 (2019)
Graphical abstract
Cell migration is a tightly-regulated process that involves protein gradients formed by the Rho family of GTPases, including Rho and Rac. The front (rear) of cells is generally characterized by higher active Rac (Rho) and lowe
Cell migration is a tightly-regulated process that involves protein gradients formed by the Rho family of GTPases, including Rho and Rac. The front (rear) of cells is generally characterized by higher active Rac (Rho) and lowe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7935ca155258214e5b1280ea17535d2
http://europepmc.org/articles/PMC6906685
http://europepmc.org/articles/PMC6906685
Autor:
Anmar Khadra, Laurent MacKay
Publikováno v:
Biophys J
Cellular migration is a tightly regulated process that involves actin cytoskeleton, adaptor proteins, and integrin receptors. Forces are transmitted extracellularly through protein complexes of these molecules, called adhesions. Adhesions anchor the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d79ff0443a963e452e6682f9b9ca51f4
https://doi.org/10.1016/j.bpj.2019.08.004
https://doi.org/10.1016/j.bpj.2019.08.004
Autor:
Anmar Khadra, Laurent MacKay
Publikováno v:
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 393-416 (2020)
Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 393-416 (2020)
Graphical abstract
Highlights • The review covers mechanisms of mechanochemical regulation of integrin-ligand bonds. • It highlights several models of clusters of force-dependent integrin-ligand bonds. • It explains how anisotropic sheer f
Highlights • The review covers mechanisms of mechanochemical regulation of integrin-ligand bonds. • It highlights several models of clusters of force-dependent integrin-ligand bonds. • It explains how anisotropic sheer f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2685326f80fc7b7ab7c40ef7e642cd63
https://pubmed.ncbi.nlm.nih.gov/32128069
https://pubmed.ncbi.nlm.nih.gov/32128069
Publikováno v:
Journal of Theoretical Biology. 512:110534
Motile cells depend on an intricate network of feedback loops that are essential in driving cell movement. Integrin-based focal adhesions (FAs) along with actin are the two key factors that mediate such motile behaviour. Together, they generate excit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ca02b0f1f929875aaf1f0c20905ef7
https://doi.org/10.1016/j.jtbi.2020.110534
https://doi.org/10.1016/j.jtbi.2020.110534
Publikováno v:
Biophysical Journal. 118:283a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c8d0714c08c4b5d72332d014a65261f
https://doi.org/10.1016/j.bpj.2019.11.1616
https://doi.org/10.1016/j.bpj.2019.11.1616
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 13, Iss 7, p e1005643 (2017)
PLoS Computational Biology, Vol 13, Iss 7, p e1005643 (2017)
The P2X4 receptor (P2X4R) is a member of a family of purinergic channels activated by extracellular ATP through three orthosteric binding sites and allosterically regulated by ivermectin (IVM), a broad-spectrum antiparasitic agent. Treatment with IVM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc1f7161ada799684ec64684d18aed81
http://europepmc.org/articles/PMC5533465
http://europepmc.org/articles/PMC5533465