Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Laurent L'homme"'
Autor:
Laurent L’homme, Benan Pelin Sermikli, Joel T. Haas, Sébastien Fleury, Sandrine Quemener, Valentine Guinot, Emelie Barreby, Nathalie Esser, Robert Caiazzo, Hélène Verkindt, Benjamin Legendre, Violeta Raverdy, Lydie Cheval, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels, Myriam Aouadi, François Pattou, Bart Staels, David Dombrowicz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Plasma growth differentiation factor-15 (GDF-15) levels increase with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) but the underlying mechanism remains poorly defined. Using male mouse models of obesity and MA
Externí odkaz:
https://doaj.org/article/0165911603514238b8604a2d501f0ef0
Autor:
Margaud Iovino, Megan Colonval, Chloé Wilkin, Laurent L’homme, Cédric Lassence, Manon Campas, Olivier Peulen, Pascal de Tullio, Jacques Piette, Sylvie Legrand-Poels
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In obesity, adipose tissue infiltrating macrophages acquire a unique pro-inflammatory polarization, thereby playing a key role in the development of chronic inflammation and Type 2 diabetes. Increased saturated fatty acids (SFAs) levels have been pro
Externí odkaz:
https://doaj.org/article/743f95f4778b494aad8b6e1a52b194ea
Autor:
Antonio Molinaro, Robert Caesar, Laurent L'homme, Ara Koh, Marcus Ståhlman, Bart Staels, Fredrik Bäckhed
Publikováno v:
Molecular Metabolism, Vol 23, Iss , Pp 82-87 (2019)
Objectives: The nuclear receptor superfamily is a potential target for the development of new treatments for obesity and metabolic diseases. Increasing evidence has pointed towards the retinoic acid-related orphan receptor-alpha (RORα) as an importa
Externí odkaz:
https://doaj.org/article/5fba586f534c4a26a0920342b16cbb9f
Autor:
Laurent L'homme, Nathalie Esser, Laura Riva, André Scheen, Nicolas Paquot, Jacques Piette, Sylvie Legrand-Poels
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 11, Pp 2998-3008 (2013)
The NLRP3 inflammasome is involved in many obesity-associated diseases, such as type 2 diabetes, atherosclerosis, and gouty arthritis, through its ability to induce interleukin (IL)-1β release. The molecular link between obesity and inflammasome act
Externí odkaz:
https://doaj.org/article/f0db1c75bf964f26a64a62fc89a30c48
in vitro models of human mast cells: How to get more and better with induced pluripotent stem cells?
Autor:
David Dombrowicz, Laurent L'homme
Publikováno v:
Journal of Allergy and Clinical Immunology
Journal of Allergy and Clinical Immunology, 2022, Online ahead of print. ⟨10.1016/j.jaci.2021.12.788⟩
Journal of Allergy and Clinical Immunology, 2022, Online ahead of print. ⟨10.1016/j.jaci.2021.12.788⟩
International audience; No abstract available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8cacd419b5969796c794c45e1ff374
https://www.hal.inserm.fr/inserm-03526347
https://www.hal.inserm.fr/inserm-03526347
Autor:
Violeta Raverdy, François Pattou, Laurent L'Homme, Laurent Pineau, David Dombrowicz, R. Caiazzo, Denis A. Mogilenko, Bruno Derudas, Bart Staels, Jerome Noulette
Publikováno v:
International Journal of Obesity
International Journal of Obesity, Nature Publishing Group, 2021, Online ahead of print. ⟨10.1038/s41366-021-00826-1⟩
International Journal of Obesity, 2021, Online ahead of print. ⟨10.1038/s41366-021-00826-1⟩
International Journal of Obesity, Nature Publishing Group, 2021, Online ahead of print. ⟨10.1038/s41366-021-00826-1⟩
International Journal of Obesity, 2021, Online ahead of print. ⟨10.1038/s41366-021-00826-1⟩
International audience; Background/Objectives: Innate lymphoid cells (ILCs) play an important role in the maintenance of immune and metabolic homeostasis in adipose tissue (AT). The crosstalk between AT ILCs and adipocytes and other immune cells coor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ffb40324e91db4d0a023a79b95e06f1
https://www.hal.inserm.fr/inserm-03220154
https://www.hal.inserm.fr/inserm-03220154
Autor:
Dombrowicz, Laurent L’homme, Benan Sermikli, Bart Staels, Jacques Piette, Sylvie Legrand-Poels, David
Publikováno v:
Nutrients; Volume 12; Issue 12; Pages: 3771
Growth differentiation factor-15 (GDF-15) and its receptor GFRAL are both involved in the development of obesity and insulin resistance. Plasmatic GDF-15 level increases with obesity and is positively associated with disease progression. Despite macr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::6496880863771ae3e4dce2901e67e15b
Autor:
Sylvie Legrand-Poels, Johan Swinnen, Yvette Habraken, Laurent L'homme, Cédric Lassence, Jonas Dehairs, Mark H. Rider, Nathalie Esser, Olivia Jansen, Gaëtan Herinckx, Nicolas Paquot, Marco Gianfrancesco, Jacques Piette
Publikováno v:
Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, Vol. 1864, no.7, p. 1017-1030 (2019)
NLRP3 inflammasome plays a key role in Western diet-induced systemic inflammation and was recently shown to mediate long-lasting trained immunity in myeloid cells. Saturated fatty acids (SFAs) are sterile triggers able to induce the assembly of the N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14962680dee589c8a435572dd3ee4c7
https://lirias.kuleuven.be/handle/123456789/654317
https://lirias.kuleuven.be/handle/123456789/654317
Autor:
Maria P. Longhi, Jörg Cammenga, Kamil R. Kranc, Samuel Pic, David Dombrowicz, Benoit Viollet, Olivier Molendi-Coste, Arnaud Villacreces, C. Becquart, Alexandra M. Bogomolova, Peter Carmeliet, Steve Lancel, Jean-Sébastien Annicotte, Christophe Paget, Joel T. Haas, Cédric Dewas, Julien Wartelle, Simon Tavernier, Luciana Berod, Nabil Rabhi, Seiichi Oyadomari, Laurent Pineau, Milica Vukovic, Bart Staels, Céline Gheeraert, Guillemette Marot, Laurent L'homme, Ezra Aksoy, Sébastien Fleury, Sandrine Quemener, Sophie Janssens, Matthieu Levavasseur, Alexis C. Boulter, Hélène Dehondt, Marc Foretz, Delphine Staumont-Sallé, Talia Velasco-Hernandez, Artemii Nikitin, Denis A. Mogilenko, Aurelie Melchior
Publikováno v:
Cell
Cell, Elsevier, 2019, 177 (5), pp.1201-1216.e19. ⟨10.1016/j.cell.2019.03.018⟩
Cell, Elsevier, 2019, 178 (1), pp.263. ⟨10.1016/j.cell.2019.06.017⟩
Cell, Elsevier, 2019, 177 (5), pp.1201-1216.e19. ⟨10.1016/j.cell.2019.03.018⟩
Cell, Elsevier, 2019, 178 (1), pp.263. ⟨10.1016/j.cell.2019.06.017⟩
International audience; Innate immune responses are intricately linked with intracellular metabolism of myeloid cells. Toll-like receptor (TLR) stimulation shifts intracellular metabolism toward glycolysis, while anti-inflammatory signals depend on e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbbc8140bb8c0e052a9fdf3a687d3ac
https://hal-univ-tours.archives-ouvertes.fr/hal-03365057
https://hal-univ-tours.archives-ouvertes.fr/hal-03365057
Autor:
Hermann Giresse Tima, Mohaned M. Sahb, Georges Potemberg, Olivier Denis, Mohsin O. Mohammed, Jacques Piette, Klarah Sherzad Baols, Laurent L'Homme, Mark S. Baird, Marta Romano, Pauline Lehebel, Roland Lang, Juma'a R. Al Dulayymi, Sylvie Legrand, Kris Huygen, Rudi Beyaert
Publikováno v:
Journal of Innate Immunity. 9:162-180
The cell wall of mycobacteria is characterised by glycolipids composed of different classes of mycolic acids (MAs; alpha-, keto-, and methoxy-) and sugars (trehalose, glucose, and arabinose). Studies using mutant Mtb strains have shown that the struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b7a9cf3604901e40a4191f2a334601f
https://doi.org/10.1159/000450955
https://doi.org/10.1159/000450955