Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laurent Hortala"'
Autor:
Torsten Haack, Laurent Hortala, Ulrich Werner, Priscilla Brun, Harivardhan Reddy Lakkireddy, Didier Bazile, Rachel Vogel, Melissa Besenius, Brigitte Illel, Matthias Urmann, Jean Alié
Publikováno v:
Advanced Drug Delivery Reviews. 106:196-222
While some orally delivered diabetes peptides are moving to late development with standard formulations incorporating functional excipients, the demonstration of the value of nanotechnology in clinic is still at an early stage. The goal of this revie
Autor:
Laurent Boulu, Francis Barth, Gérard Fabre, Murielle Rinaldi-Carmona, Christian Congy, Olivier Finance, Freddy Sadoun, Laurent Hortala
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:4573-4577
A new series of 2,3-diarylpyrroles have been prepared and evaluated as CB(1) antagonists. Modulation of the topological polar surface area allowed the identification of high affinity peripherally-restricted CB(1) antagonists. Compound 11, obtained af
Autor:
Fredrik Rahm, Ulf Bremberg, Laurent Hortala, Guy Quéguiner, Emmanuel Macedo, J. Bourguignon, G. Dupas, Vincent Levacher, Christina Moberg, Kristina Hallman, Serghey Lutsenko, Lars Hagberg
Publikováno v:
Tetrahedron. 59:9583-9589
Chiral pyridinooxazoline, quinolinooxazoline, bis(oxazolino)pyridine (pybox), and bisoxazoline (box) derivatives containing crown ether residues were prepared. Some of the ligands were assessed in substrate binding studies and in palladium catalyzed
Autor:
Joël Poncet, Laurent Hortala, Francoise Gueritte-Voegelein, Ghanem Atassi, Sylvie Thoret, Alain Pierré, Magali Busquet, Patrick Jouin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 8:2855-2858
A cyclic analog of the natural antiproliferative compound dolastatin 10 was synthesized by introducing an ester link between the N- and C-terminal residues which were modified accordingly. The final macrolactonization was performed by using isopropen
Publikováno v:
Tetrahedron Letters. 43:1027-1029
A significant acceleration of acyl transfer has been achieved on 8-acetoxy-2-oxazolinylquinoline in the presence of benzylamine. Comparison of the aminolysis by the new acylating reagent with that ...
Autor:
Magali Busquet, Francoise Gueritte-Voegelein, Sylviane Thoret, Alain Pierré, Patrick Jouin, Joël Poncet, Laurent Hortala, Ghanem Atassi
Publikováno v:
ChemInform. 30