Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Laurent Holtzer"'
Publikováno v:
Stem Cell Research, Vol 61, Iss , Pp 102748- (2022)
Important challenges in stem cell research and regenerative medicine are reliable assessment of pluripotency state and purity of differentiated cell populations. Pluripotency and differentiation are regulated and determined by activity of development
Externí odkaz:
https://doaj.org/article/da7fca7fbde74de39703fbf02014bd22
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Combined cellular and humoral host immune response determine the clinical course of a viral infection and effectiveness of vaccination, but currently the cellular immune response cannot be measured on simple blood samples. As functional activity of i
Externí odkaz:
https://doaj.org/article/cf46683226d1410a9468f5254c7a4c2a
Autor:
Rita Mateus, Laurent Holtzer, Carole Seum, Zena Hadjivasiliou, Marine Dubois, Frank Jülicher, Marcos Gonzalez-Gaitan
Publikováno v:
Cell Reports, Vol 30, Iss 12, Pp 4292-4302.e7 (2020)
Summary: Secreted growth factors can act as morphogens that form spatial concentration gradients in developing organs, thereby controlling growth and patterning. For some morphogens, adaptation of the gradients to tissue size allows morphological pat
Externí odkaz:
https://doaj.org/article/f20137627b1d43f5857501a458f5ea8d
Autor:
Sylvain Loubéry, Alicia Daeden, Carole Seum, Laurent Holtzer, Ana Moraleda, Nicolas Damond, Emmanuel Derivery, Thomas Schmidt, Marcos Gonzalez-Gaitan
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Asymmetric segregation of cell fate determinants during cell division governs daughter cell fate. Here the authors show that Sara endosomes, known to regulate Notch signalling, are targeted to the mitotic spindle and once phosphorylated are asymmetri
Externí odkaz:
https://doaj.org/article/4e05d4052c0e463fa6494f9179a2fc71
Autor:
Laurent Holtzer, Igor Oleinich, Marcello Anzola, Eric Lindberg, Kalyan K. Sadhu, Marcos Gonzalez-Gaitan, Nicolas Winssinger
Publikováno v:
ACS Central Science, Vol 2, Iss 6, Pp 394-400 (2016)
Externí odkaz:
https://doaj.org/article/62f89ecd5f7a4698a74e881dbdf76a1a
Publikováno v:
Stem cell research. 61
Stem cell research is emerging both as a scientifically and clinically relevant area. One of the current challenges in stem cell research and regenerative medicine is assessment of the pluripotency state of induced pluripotent stem (iPS) cells. Once
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Signal transduction pathways are important in physiology and pathophysiology. Targeted drugs aim at modifying pathogenic pathway activity, e.g., in cancer. Optimal treatment choice requires assays to measure pathway activity in individual patient tis
Autor:
Rico Hagelaar, Kirsten Canté-Barrett, Laurent Holtzer, Wim Verhaegh, Valentina Cordo, Anja van de Stolpe, Henk van Ooijen, Jules P.P. Meijerink
Publikováno v:
Cancers, Vol 12, Iss 3142, p 3142 (2020)
Canté-Barrett, K, Holtzer, L, van Ooijen, H, Hagelaar, R, Cordo', V, Verhaegh, W, van de Stolpe, A & Meijerink, J P P 2020, ' A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer ', Cancers, vol. 12, no. 11, 3142, pp. 1-17 . https://doi.org/10.3390/cancers12113142
Cancers
Volume 12
Issue 11
Canté-Barrett, K, Holtzer, L, van Ooijen, H, Hagelaar, R, Cordo', V, Verhaegh, W, van de Stolpe, A & Meijerink, J P P 2020, ' A Molecular Test for Quantifying Functional Notch Signaling Pathway Activity in Human Cancer ', Cancers, vol. 12, no. 11, 3142, pp. 1-17 . https://doi.org/10.3390/cancers12113142
Cancers
Volume 12
Issue 11
Simple Summary The Notch signal transduction pathway is important for various physiological processes, including immune responses, and plays a role in many diseases, for example cancer. We have developed a new assay to quantitatively measure Notch pa
Autor:
Valentina Cordo, Kirsten Canté-Barrett, Henk van Ooijen, Rico Hagelaar, Laurent Holtzer, Anja van de Stolpe, Wim Verhaegh, Jules P.P. Meijerink
The Notch signal transduction pathway is pivotal for various physiological processes including immune responses, and has been implicated in the pathogenesis of many diseases including T-cell acute lymphoblastic leukemia. Various targeted drugs are av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2294ee411456af2abbbdf521e4ea549
https://doi.org/10.1101/2020.07.10.183731
https://doi.org/10.1101/2020.07.10.183731
The host immune response determines the clinical course of a viral infection, for example in case of COVID-19 infection. The effectiveness of vaccination also depends on the induced immune response. Currently there is no method to measure the cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27404c095cbfe62cf662d7e28669234c
https://doi.org/10.1101/2020.05.13.092759
https://doi.org/10.1101/2020.05.13.092759