Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Laurent Hollecker"'
Autor:
Francesca Argiolas, Maria Barbara Pinna, Alessandra Incani, Angela Atzeri, D Loru, Antonella Rosa, Maria Paola Melis, B Cabboi, Laurent Hollecker, Maria Assunta Dessì, Mariano Murru, Monica Deiana
Publikováno v:
Food Chemistry. 134:2105-2113
One of the most important sites of polyphenol action seems to be in the gastrointestinal system before absorption. We investigated the ability of three wine phenolic extracts, obtained from grape varieties grown in Sardinia, Cannonau (red), Vermentin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfddf47acc7fccc9d3ff50b0d9bafa27
https://doi.org/10.1016/j.foodchem.2012.04.014
https://doi.org/10.1016/j.foodchem.2012.04.014
Publikováno v:
Journal of Carbohydrate Chemistry. 25:461-470
The synthesis of methyl 3,5‐di‐O‐benzoyl‐2‐deoxy‐2‐fluoro‐2‐C‐methyl‐β‐D‐ribofuranoside and the conversion to the corresponding 1‐O‐acetyl‐3,5‐di‐O‐benzoyl‐2‐deoxy‐2‐fluoro‐2‐C‐methyl‐D‐ribofur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a261532bd7c52a0a3026a0ddd9412b0e
https://doi.org/10.1080/07328300600859783
https://doi.org/10.1080/07328300600859783
Autor:
Wojciech J. Stec, Michael J. Otto, Lieven J. Stuyver, Jeremy L. Clark, J. Christian Mason, Steven E. Patterson, Tamara R. McBrayer, Raymond F. Schinazi, Stefania Lostia, Phillip M. Tharnish, Furman Phillip, Laurent Hollecker, Kyoichi A. Watanabe, Krzysztof W. Pankiewicz
Publikováno v:
Journal of Medicinal Chemistry. 48:5504-5508
The pyrimidine nucleoside beta-d-2‘-deoxy-2‘-fluoro-2‘-C-methylcytidine (1) was designed as a hepatitis C virus RNA-dependent RNA polymerase (HCV RdRp) inhibitor. The title compound was obtained by a DAST fluorination of N4-benzoyl-1-(2-methyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::271a0cc0770854413bb030ada7bde62e
https://doi.org/10.1021/jm0502788
https://doi.org/10.1021/jm0502788
Autor:
Laurent Hollecker, B Cabboi, Antonella Rosa, M. A. Dessì, Mp Melis, Angela Atzeri, Monica Deiana, Alessandra Incani, D Loru
Publikováno v:
Journal of Biological Research, Vol 84, Iss 1 (2011)
The aim of this study was to compare the antioxidant capacities of the phenolic fraction of wines from Vitis vinifera grapes cultivated in Sardinia (three native: Cannonau, Malvasia, Vermentino and three non-native types: Cabernet-sauvignon, Chardonn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::633ab65cc00dc42b5a08e4ae2916d588
https://doi.org/10.4081/jbr.2011.4631
https://doi.org/10.4081/jbr.2011.4631
Autor:
Laurent Hollecker, Mariano Murru, Maurizio Pinna, Francesca Argiolas, Barbara Pinna, Giorgia Filippino, Stefania Scrugli
Publikováno v:
Journal of chromatography. A. 1216(15)
A new method for the identification and the quantification of nonanthocyanin phenolic compounds from six Vitis Vinifera grape varieties native to Sardinia (three native: Vermentino, Malvasia and Cannonau and three non-native types: Chardonnay, Sauvig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00e9f72732a1921e23aec9731ff8dc1
https://pubmed.ncbi.nlm.nih.gov/19249789
https://pubmed.ncbi.nlm.nih.gov/19249789
Publikováno v:
ChemInform. 38
The synthesis of methyl 3,5‐di‐O‐benzoyl‐2‐deoxy‐2‐fluoro‐2‐C‐methyl‐β‐D‐ribofuranoside and the conversion to the corresponding 1‐O‐acetyl‐3,5‐di‐O‐benzoyl‐2‐deoxy‐2‐fluoro‐2‐C‐methyl‐D‐ribofur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74899c596f762c188171bc30976027c6
https://doi.org/10.1002/chin.200704188
https://doi.org/10.1002/chin.200704188
Autor:
Meng-Yu Xie, Tamara R. McBrayer, John D. Morrey, Laurent Hollecker, Stefania Lostia, Tammy Nachman, Michael J. Otto, Lieven Stuyver, Jason Grier, Phillip A. Furman, Clark Jeremy, Justin L Julander, Raymond F. Schinazi, Matthew A Bennett, Phillip M Tharnish
Publikováno v:
Antiviral chemistrychemotherapy. 17(2)
β-D-2′-Deoxy-2′-fluoro-2′- C-methylcytidine (PSI-6130) is a cytidine analogue with potent and selective anti-hepatitis C virus (HCV) activity in the subgenomic HCV replicon assay, 90% effective concentration (EC90)=4.6 +2.0 µM. The spectrum o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bf90d30891e8fe4245caa2a9dbaa45
https://pubmed.ncbi.nlm.nih.gov/17042329
https://pubmed.ncbi.nlm.nih.gov/17042329
Publikováno v:
ChemInform. 37
A new approach to the synthesis of 2′,3′-didehydro-2′,3′-dideoxynucleosides was described in excellent yield through unusual olefin formation by PhSe-F trans-elimination.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac56095652f04ba41f02cc97b097d493
https://doi.org/10.1002/chin.200608185
https://doi.org/10.1002/chin.200608185
Autor:
Jinfa Du, Byoung-Kwon Chun, Stefania Lostia, Lieven J. Stuyver, Junxing Shi, Laurent Hollecker, Raymond F. Schinazi, Tammy Nachman, Michael J. Otto, Kyoichi A. Watanabe
Publikováno v:
Nucleosides, nucleotidesnucleic acids. 24(8)
Novel racemic, D- and L-beta-dioxolane N4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198de29239341a5b1f457f1d465b9d1f
https://pubmed.ncbi.nlm.nih.gov/16270663
https://pubmed.ncbi.nlm.nih.gov/16270663
Autor:
Kyoichi A. Watanabe, Tamara R. McBrayer, Raymond F. Schinazi, Lieven Stuyver, Laurent Hollecker, Phillip M Tharnish, J. Christian Mason, Phillip A. Furman, Jeremy L. Clark, Michael J. Otto
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(6)
A series of purine nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methylribofuranosyl moiety were synthesized and evaluated as potential inhibitors of the hepatitis C virus in vitro. Of the nucleosides that were synthesized, only those possessing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afaa96bf5dbb56ec246735f288bcee9e
https://pubmed.ncbi.nlm.nih.gov/16368235
https://pubmed.ncbi.nlm.nih.gov/16368235