Výsledky vyhledávání - "Laurent Hansen"

Spectroscopic evaluation of a freeze-dried vaccine during an accelerated stability study

Autor: Jean Paul Remon, Laurent Hansen, Jeroen Van Renterghem, Rim Daoussi, Chris Vervaet, Thomas De Beer

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 104:89-100

This research evaluates a freeze-dried live, attenuated virus vaccine during an accelerated stability study using Near Infrared (NIR) and Fourier Transform Infrared (FTIR) spectroscopy in addition to the traditional quality tests (i.e., potency assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c08373c5fd486c83e0172b3054d761
https://doi.org/10.1016/j.ejpb.2016.04.010

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FTIR spectroscopy for the detection and evaluation of live attenuated viruses in freeze dried vaccine formulations

Autor: Rim Daoussi, Jean Paul Remon, Soumya Pastoret, Laurent Hansen, Karin Pierre, Chris Vervaet, Thomas De Beer, Astrid Bonnegarde-Bernard

Publikováno v: BIOTECHNOLOGY PROGRESS

This article examines the applicability of Fourier Transform Infrared (FTIR) spectroscopy to detect the applied virus medium volume (i.e., during sample filling), to evaluate the virus state and to distinguish between different vaccine doses in a fre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4faeb0ab1165ec6de558895f4d43f81c
https://pubmed.ncbi.nlm.nih.gov/25960257

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Release characteristics of polyurethane tablets containing dicarboxylic acids as release modifiers - a case study with diprophylline

Autor: Chris Vervaet, Thomas De Beer, Laurent Hansen, Sander De Bruyn, Jean Paul Remon, Bart Claeys

Publikováno v: INTERNATIONAL JOURNAL OF PHARMACEUTICS

The influence of several dicarboxylic acids on the release characteristics of polyurethane tablets with a high drug load was investigated. Mixtures of diprophylline (Dyph) and thermoplastic polyurethane (TPUR) (ratio: 50/50, 65/35 and 75/25 wt.%) wer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5666e3253cef458e2d6acf36f920e67b
https://pubmed.ncbi.nlm.nih.gov/25445517

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Thermoplastic polyurethanes for the manufacturing of highly dosed oral sustained release matrices via hot melt extrusion and injection molding

Autor: Laurent Hansen, Xander K.D. Hillewaere, Chris Vervaet, Thomas De Beer, Sam Possemiers, Bart Claeys, Jean Paul Remon, Anouk Vervaeck

Publikováno v: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

This study evaluated thermoplastic polyurethanes (TPUR) as matrix excipients for the production of oral solid dosage forms via hot melt extrusion (HME) in combination with injection molding (IM). We demonstrated that TPURs enable the production of so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4c744447f906e786d7399d78f5d1e6
https://pubmed.ncbi.nlm.nih.gov/25448075

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Near-infrared spectroscopic evaluation of lyophilized viral vaccine formulations

Autor: Jean Paul Remon, Chris Vervaet, Yvan Vander Heyden, Thomas De Beer, Rim Daoussi, Sigrid Pieters, Jean-Pierrre Montenez, Laurent Hansen

Publikováno v: BIOTECHNOLOGY PROGRESS
Vrije Universiteit Brussel

This article examines the applicability of near-infrared spectroscopy (NIRS) to evaluate the virus state in a freeze-dried live, attenuated vaccine formulation. Therefore, this formulation was freeze-dried using different virus volumes and after appl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5846f51428f280e734244d68b152a6
https://biblio.ugent.be/publication/4270700/file/4270714

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Raman spectroscopy and multivariate analysis for the rapid discrimination between native-like and non-native states in freeze-dried protein formulations

Autor: Yvan Vander Heyden, Bart De Spiegeleer, Jean Paul Remon, Jean-Michel Roger, Laurent Hansen, Sigrid Pieters, Matthias D'Hondt, B. Palagos, Chris Vervaet, Thomas De Beer

Publikováno v: Vrije Universiteit Brussel
European Journal of Pharmaceutics and Biopharmaceutics
European Journal of Pharmaceutics and Biopharmaceutics, Elsevier, 2013, 85 (2), p. 263-p. 271. ⟨10.1016/j.ejpb.2013.03.035⟩

This study investigates whether Raman spectroscopy combined with multivariate analysis (MVA) enables a rapid and direct differentiation between two classes of conformational states, i.e., native-like and non-native proteins, in freeze-dried formulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::086a65298a6d0689a149483a4c8db690
https://researchportal.vub.be/en/publications/bd5aaab5-403f-4cb0-83ee-558f7861d6b3

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