Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laurent Gole"'
Autor:
Xinmi Huo, Kok Haur Ong, Kah Weng Lau, Laurent Gole, David M. Young, Char Loo Tan, Xiaohui Zhu, Chongchong Zhang, Yonghui Zhang, Longjie Li, Hao Han, Haoda Lu, Jing Zhang, Jun Hou, Huanfen Zhao, Hualei Gan, Lijuan Yin, Xingxing Wang, Xiaoyue Chen, Hong Lv, Haotian Cao, Xiaozhen Yu, Yabin Shi, Ziling Huang, Gabriel Marini, Jun Xu, Bingxian Liu, Bingxian Chen, Qiang Wang, Kun Gui, Wenzhao Shi, Yingying Sun, Wanyuan Chen, Dalong Cao, Stephan J. Sanders, Hwee Kuan Lee, Susan Swee-Shan Hue, Weimiao Yu, Soo Yong Tan
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-13 (2024)
Abstract Background Artificial Intelligence(AI)-based solutions for Gleason grading hold promise for pathologists, while image quality inconsistency, continuous data integration needs, and limited generalizability hinder their adoption and scalabilit
Externí odkaz:
https://doaj.org/article/c5026c6f9d9540348f7717c223adff6f
Autor:
Laurent Gole, Feng Liu, Kok Haur Ong, Longjie Li, Hao Han, David Young, Gabriel Pik Liang Marini, Aileen Wee, Jingmin Zhao, Huiying Rao, Weimiao Yu, Lai Wei
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The novel targeted therapeutics for hepatitis C virus (HCV) in last decade solved most of the clinical needs for this disease. However, despite antiviral therapies resulting in sustained virologic response (SVR), a challenge remains where th
Externí odkaz:
https://doaj.org/article/1ad235e0a7b34bf6aa2bad6e5e2b0113
Autor:
Laurent Gole, Joe Yeong, Jeffrey Chun Tatt Lim, Kok Haur Ong, Hao Han, Aye Aye Thike, Yong Cheng Poh, Sidney Yee, Jabed Iqbal, Wanjin Hong, Bernett Lee, Weimiao Yu, Puay Hoon Tan
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-13 (2020)
Abstract Background Stromal and collagen biology has a significant impact on tumorigenesis and metastasis. Collagen is a major structural extracellular matrix component in breast cancer, but its role in cancer progression is the subject of historical
Externí odkaz:
https://doaj.org/article/6c2e51defd8b4e8babd863727565f336
Autor:
Martine C. Morrison, Lars Verschuren, Kanita Salic, Joanne Verheij, Aswin Menke, Peter Y. Wielinga, Marta Iruarrizaga‐Lejarreta, Laurent Gole, Wei‐Miao Yu, Scott Turner, Martien P.M. Caspers, Ibon Martínez‐Arranz, Elsbet Pieterman, Reinout Stoop, Arianne van Koppen, Anita M. van den Hoek, José M. Mato, Roeland Hanemaaijer, Cristina Alonso, Robert Kleemann
Publikováno v:
Hepatology Communications, Vol 2, Iss 12, Pp 1513-1532 (2018)
Concerns have been raised about whether preclinical models sufficiently mimic molecular disease processes observed in nonalcoholic steatohepatitis (NASH) patients, bringing into question their translational value in studies of therapeutic interventio
Externí odkaz:
https://doaj.org/article/b7dbea0375ad493383bf24d4d1bb040c
Autor:
Xinmi Huo, KokHaur ONG, Kah Weng Lau, Laurent Gole, David Young, Char Loo Tan, Chongchong Zhang, Yonghui Zhang, Xiaohui Zhu, Longjie Li, Hao Han, Haoda Lu, Gabriel Marini, Jun Xu, Kun Gui, Bingxian Chen, Wenzhao Shi, Wanyuan Chen, Stephan Sanders, Hwee Kuan Lee, Susan Swee-Shan Hue, Weimiao Yu, Soo Yong Tan
AI-based solutions for automated Gleason grading have been developed to assist pathologists to make rapid and quantitative assessments, but the generalization across various scanners and updating AI models continuously using new annotated data from e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ba4393ee3557b58efd813039bb0a381
https://doi.org/10.21203/rs.3.rs-1917695/v1
https://doi.org/10.21203/rs.3.rs-1917695/v1
Autor:
Longjie Li, Arun Mouli Kolinjivadi, Kok Haur Ong, David M Young, Gabriel Pik Liang Marini, Sock Hoai Chan, Siao Ting Chong, Ee Ling Chew, Haoda Lu, Laurent Gole, Weimiao Yu, Joanne Ngeow
Motivation DNA fibre assay has a potential application in genomic medicine, cancer and stem cell research at the single-molecule level. A major challenge for the clinical and research implementation of DNA fibre assays is the slow speed in which manu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97942eadae10fcde42e271141a58020e
https://hdl.handle.net/10356/164980
https://hdl.handle.net/10356/164980
Autor:
Weimiao Yu, Stephen Sanders, Laurent Gole, Grace Schwartz, David M. Young, Zachary Bonzell, Deniz Yuruk, John L.R. Rubenstein, Siavash Fazel Darbandi, Mai Nojima
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
3D imaging data necessitate 3D reference atlases for accurate quantitative interpretation. Existing computational methods to generate 3D atlases from 2D-derived atlases result in extensive artifacts, while manual curation approaches are labor-intensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92644e2bdc14464ae70803f3c5d33147
https://doi.org/10.7554/elife.61408
https://doi.org/10.7554/elife.61408
Autor:
Laurent Gole, Stephen Sanders, Grace Schwartz, David M. Young, Weimiao Yu, Zachary Bonzell, Siavash Fazel Darbandi, Deniz Yuruk, Mai Nojima, John L.R. Rubenstein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da9825541617a3854912e5cdc407e694
https://doi.org/10.7554/elife.61408.sa2
https://doi.org/10.7554/elife.61408.sa2
Autor:
Joe Yeong, Jeffrey Chun Tatt Lim, Kok Haur Ong, Laurent Gole, Yong Cheng Poh, Weimiao Yu, Jabed Iqbal, Puay Hoon Tan, Sidney Yee, Bernett Lee, Aye Aye Thike, Hao Han, Wanjin Hong
Publikováno v:
Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-13 (2020)
Breast Cancer Research, Vol 22, Iss 1, Pp 1-13 (2020)
Background Stromal and collagen biology has a significant impact on tumorigenesis and metastasis. Collagen is a major structural extracellular matrix component in breast cancer, but its role in cancer progression is the subject of historical debate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a826ec17519d1d35ad135252c103b1
https://doi.org/10.1186/s13058-020-01282-x
https://doi.org/10.1186/s13058-020-01282-x
Publikováno v:
Nature Cell Biology. 19:988-995
Cell polarization enables zygotes to acquire spatial asymmetry, which in turn patterns cellular and tissue axes during development. Local modification in the actomyosin cytoskeleton mediates spatial segregation of partitioning-defective (PAR) protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79e70c8f862a18fe5ffc78532e93fab
https://doi.org/10.1038/ncb3577
https://doi.org/10.1038/ncb3577