Disordered regions of human eIF4B orchestrate a dynamic self-association landscape

Autor: Bikash Chandra Swain, Pascale Sarkis, Vanessa Ung, Sabrina Rousseau, Laurent Fernandez, Ani Meltonyan, V. Esperance Aho, Davide Mercadante, Cameron D. Mackereth, Mikayel Aznauryan

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Eukaryotic translation initiation factor eIF4B is required for efficient cap-dependent translation, it is overexpressed in cancer cells, and may influence stress granule formation. Due to the high degree of intrinsic disorder, eIF4B is rarel

Externí odkaz: https://doaj.org/article/faf2eb2ccf9f4538a76de5ae612d6eb5

TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

Autor: Clément Chevalier, Guillaume Collin, Simon Descamps, Heiani Touaitahuata, Valérie Simon, Nicolas Reymond, Laurent Fernandez, Pierre-Emmanuel Milhiet, Virginie Georget, Serge Urbach, Laurence Lasorsa, Béatrice Orsetti, Florence Boissière-Michot, Evelyne Lopez-Crapez, Charles Theillet, Serge Roche, Christine Benistant

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)

ERBB2 overexpression in human breast cancer leads to invasion and metastasis. Here the authors report that ERBB2 induces indirect phosphorylation of TOM1L1 that promotes trafficking of the metalloprotease MT1-MMP to invadopodia, which leads to tumour

Externí odkaz: https://doaj.org/article/428262dc08104141b0e2cd95b257a423

Nanoscale organization of tetraspanins during HIV-1 budding by correlative dSTORM/AFM

Autor: Laurent Fernandez, Antoine Le Gall, Eric Rubinstein, Célia Chamontin, Marylène Mougel, Pierre-Emmanuel Milhiet, Selma Dahmane, Patrice Dosset, Florent Murcy, Marcelo Nollmann, Desiree Salas, Christine Doucet

Publikováno v: Nanoscale
Nanoscale, 2019, 11 (13), pp.6036-6044. ⟨10.1039/c8nr07269h⟩
Nanoscale, Royal Society of Chemistry, 2019, 11 (13), pp.6036-6044. ⟨10.1039/c8nr07269h⟩

International audience; Membrane partition and remodeling play a key role in numerous cell mechanisms, especially in viral replication cycles where viruses subvert the plasma membrane to enter and escape from the host cell. Specifically assembly and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa38c79c7311b9e8a7c2a06088f2635
https://doi.org/10.1039/c8nr07269h

TOM1L1 drives membrane delivery of MT1-MMP to promote ERBB2-induced breast cancer cell invasion

Autor: Béatrice Orsetti, Virginie Georget, Christine Benistant, Guillaume Collin, Heiani Touaitahuata, Laurent Fernandez, Charles Theillet, Simon Descamps, Pierre-Emmanuel Milhiet, Florence Boissière-Michot, Evelyne Lopez-Crapez, Serge Roche, Clément Chevalier, Nicolas Reymond, Serge Urbach, Laurence Lasorsa, Valérie Simon

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Nature Communications
Nature Communications, 2016, 7 (1), pp.10765. ⟨10.1038/ncomms10765⟩
Nature Communications, Nature Publishing Group, 2016, 7 (1), pp.10765. ⟨10.1038/ncomms10765⟩

ERBB2 overexpression in human breast cancer leads to invasive carcinoma but the mechanism is not clearly understood. Here we report that TOM1L1 is co-amplified with ERBB2 and defines a subgroup of HER2+/ER+ tumours with early metastatic relapse. TOM1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfdc87eb089920bc249cc6b27ddb43f
https://doaj.org/article/428262dc08104141b0e2cd95b257a423

Automatic detection of diffusion modes within biological membranes using back-propagation neural network

Autor: Laurent Fernandez, Pierre-Emmanuel Milhiet, Emmanuel Margeat, Patrice Dosset, Patrice Rassam, Eric Rubinstein, Cedric Espenel

Publikováno v: BMC Bioinformatics
BMC Bioinformatics, BioMed Central, 2016, 17 (1), pp.197. ⟨10.1186/s12859-016-1064-z⟩
BMC Bioinformatics, 2016, 17 (1), pp.197. ⟨10.1186/s12859-016-1064-z⟩

Background Single particle tracking (SPT) is nowadays one of the most popular technique to probe spatio-temporal dynamics of proteins diffusing within the plasma membrane. Indeed membrane components of eukaryotic cells are very dynamic molecules and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37e8dab75589bcabdb3bfbf4f8d9506
https://www.hal.inserm.fr/inserm-01322561/document