Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Laurent Coscoy"'
Autor:
Chan-Su Park, Jian Guan, Peter Rhee, Federico Gonzalez, Hee-sung Lee, Ji-hyun Park, Laurent Coscoy, Ellen A Robey, Nilabh Shastri, Scheherazade Sadegh-Nasseri
Publikováno v:
eLife, Vol 13 (2024)
The fate of developing T cells is determined by the strength of T cell receptor (TCR) signal they receive in the thymus. This process is finely regulated through the tuning of positive and negative regulators in thymocytes. The Family with sequence s
Externí odkaz:
https://doaj.org/article/5dac43e64dda4b1c805566d173e337bf
Autor:
Michael Manoharan Valerio, Kathya Arana, Jian Guan, Shiao Wei Chan, Xiaokun Yang, Nadia Kurd, Angus Lee, Nilabh Shastri, Laurent Coscoy, Ellen A. Robey
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
MHC-E restricted CD8 T cells show promise in vaccine settings, but their development and specificity remain poorly understood. Here we focus on a CD8 T cell population reactive to a self-peptide (FL9) bound to mouse MHC-E (Qa-1b) that is presented in
Externí odkaz:
https://doaj.org/article/39ecc32a95a34e96b4b07cd3ca823fbb
Autor:
Kristina M. Geiger, Michael Manoharan, Rachel Coombs, Kathya Arana, Chan-Su Park, Angus Y. Lee, Nilabh Shastri, Ellen A. Robey, Laurent Coscoy
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112317- (2023)
Summary: The endoplasmic reticulum aminopeptidase associated with antigen processing (ERAAP) plays a crucial role in shaping the peptide-major histocompatibility complex (MHC) class I repertoire and maintaining immune surveillance. While murine cytom
Externí odkaz:
https://doaj.org/article/1eb0def2d54145d79e3f806380bb3bbe
Autor:
Trever T Greene, Maria Tokuyama, Giselle M Knudsen, Michele Kunz, James Lin, Alexander L Greninger, Victor R DeFilippis, Joseph L DeRisi, David H Raulet, Laurent Coscoy
Publikováno v:
eLife, Vol 5 (2016)
Natural Killer (NK) cells are essential for control of viral infection and cancer. NK cells express NKG2D, an activating receptor that directly recognizes NKG2D ligands. These are expressed at low level on healthy cells, but are induced by stresses l
Externí odkaz:
https://doaj.org/article/d8a20529d68d4330954a91b352d12e16
Autor:
Benjamin G Gowen, Bryan Chim, Caleb D Marceau, Trever T Greene, Patrick Burr, Jeanmarie R Gonzalez, Charles R Hesser, Peter A Dietzen, Teal Russell, Alexandre Iannello, Laurent Coscoy, Charles L Sentman, Jan E Carette, Stefan A Muljo, David H Raulet
Publikováno v:
eLife, Vol 4 (2015)
Recognition and elimination of tumor cells by the immune system is crucial for limiting tumor growth. Natural killer (NK) cells become activated when the receptor NKG2D is engaged by ligands that are frequently upregulated in primary tumors and on ca
Externí odkaz:
https://doaj.org/article/a4e5c71a5135497bb2c7f44fa9a2c713
Autor:
Emma Abernathy, Karen Clyde, Rukhsana Yeasmin, Laurie T Krug, Al Burlingame, Laurent Coscoy, Britt Glaunsinger
Publikováno v:
PLoS Pathogens, Vol 10, Iss 1, p e1003882 (2014)
Lytic gammaherpesvirus infection restricts host gene expression by promoting widespread degradation of cytoplasmic mRNA through the activity of the viral endonuclease SOX. Though generally assumed to be selective for cellular transcripts, the extent
Externí odkaz:
https://doaj.org/article/b574d0c37c3f4438af144f39c2980b9a
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003748 (2013)
Activation-induced cytidine deaminase (AID) is specifically induced in germinal center B cells to carry out somatic hypermutation and class-switch recombination, two processes responsible for antibody diversification. Because of its mutagenic potenti
Externí odkaz:
https://doaj.org/article/f696d7105d1146e191c037433cd0fe67
Autor:
Maria Tokuyama, Clarisse Lorin, Frederic Delebecque, Heiyoun Jung, David H Raulet, Laurent Coscoy
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002265 (2011)
Natural killer (NK) cells are lymphocytes that play a major role in the elimination of virally-infected cells and tumor cells. NK cells recognize and target abnormal cells through activation of stimulatory receptors such as NKG2D. NKG2D ligands are s
Externí odkaz:
https://doaj.org/article/4129d8cfa24c4dc7a5e96083733a4636
Autor:
Justin M Richner, Karen Clyde, Andrea C Pezda, Benson Yee Hin Cheng, Tina Wang, G Renuka Kumar, Sergio Covarrubias, Laurent Coscoy, Britt Glaunsinger
Publikováno v:
PLoS Pathogens, Vol 7, Iss 7, p e1002150 (2011)
During a lytic gammaherpesvirus infection, host gene expression is severely restricted by the global degradation and altered 3' end processing of mRNA. This host shutoff phenotype is orchestrated by the viral SOX protein, yet its functional significa
Externí odkaz:
https://doaj.org/article/f84bbc17fbcc49f997bc64b1bd244b0d
Autor:
Thomas R. Carey, Molly Kozminsky, Jennifer Hall, Valerie Vargas-Zapata, Kristina Geiger, Laurent Coscoy, Lydia L. Sohn
Publikováno v:
medRxiv
The COVID-19 pandemic has revealed how an emerging pathogen can cause a sudden and dramatic increase in demand for viral testing. Testing pooled samples could meet this demand; however, the sensitivity of reverse transcription quantitative polymerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b35abcf8cab05c8740f35d4fef45c4
https://doi.org/10.1021/acs.analchem.2c00835
https://doi.org/10.1021/acs.analchem.2c00835